New drug combo aims to fight tough lung cancer
NCT ID NCT07227597
First seen Jun 26, 2026 · Last updated Jul 21, 2026 · Updated 7 times
Summary
This study tests two experimental drugs, gocatamig and ifinatamab deruxtecan, alone or with standard chemotherapy and immunotherapy, for people with extensive-stage small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. About 170 participants will take part in this early-phase trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- gocatamig (MK-6070) and ifinatamab deruxtecan (I-DXd)
- What this could lead to
- If successful, this combination could offer a new treatment option for extensive-stage small cell lung cancer, potentially improving response rates.
- What could go wrong
- This is an early-phase trial (1b/2) with a small number of participants, so safety and effectiveness are not yet proven. Side effects like cytokine release syndrome are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center ( Site 1404)
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-••••
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Avera Cancer Institute- Research ( Site 0104)
RECRUITINGSioux Falls, South Dakota, 57105, United States
Contact Phone: •••-•••-••••
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Beijing Cancer Hospital ( Site 1604)
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-••••
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Bradfordhill ( Site 0201)
RECRUITINGSantiago, Region M. de Santiago, 8420383, Chile
Contact Phone: •••-•••-••••
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CEMIC ( Site 1903)
RECRUITINGCaba., Buenos Aires, C1431FWO, Argentina
Contact Phone: •••-•••-••••
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FALP ( Site 0200)
RECRUITINGSantiago, Region M. de Santiago, 7500921, Chile
Contact Phone: •••-•••-••••
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Faculty of Medicine Siriraj Hospital ( Site 3000)
RECRUITINGBangkoknoi, Bangkok, 10700, Thailand
Contact Phone: •••-•••-••••
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Hospital Austral ( Site 1901)
RECRUITINGPilar, Buenos Aires, B1629AHJ, Argentina
Contact Phone: •••-•••-••••
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Hospital San Pedro ( Site 1004)
RECRUITINGLogroño, La Rioja, 26006, Spain
Contact Phone: •••-•••-••••
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Hospital Universitario Insular de Gran Canaria ( Site 1002)
RECRUITINGLas Palmas de Gran Canaria, Las Palmas, 35016, Spain
Contact Phone: •••-•••-••••
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Houston Methodist Hospital - Houston Methodist Neal Cancer Center ( Site 0113)
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-••••
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Jiangmen Central Hospital ( Site 1611)
RECRUITINGJiangmen, Guangdong, 529000, China
Contact Phone: •••-•••-••••
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John Theurer Cancer Center at Hackensack University Medical Center ( Site 0101)
RECRUITINGHackensack, New Jersey, 07601, United States
Contact Phone: •••-•••-••••
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Lt. Col. Luke Weathers, Jr. VA Medical Center ( Site 0133)
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Phone: •••-•••-••••
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Orlando Health Cancer Institute ( Site 0108)
RECRUITINGOrlando, Florida, 32806, United States
Contact Phone: •••-•••-••••
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Pontificia Universidad Catolica de Chile ( Site 0202)
RECRUITINGSantiago, Region M. de Santiago, 8330032, Chile
Contact Phone: •••-•••-••••
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Providence Cancer Institute, Franz Clinic - Eastside ( Site 0107)
RECRUITINGPortland, Oregon, 97213, United States
Contact Phone: •••-•••-••••
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Providence Medical Foundation ( Site 0124)
RECRUITINGSanta Rosa, California, 95403, United States
Contact Phone: •••-•••-••••
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Rambam Health Care Campus ( Site 0602)
RECRUITINGHaifa, 3109601, Israel
Contact Phone: •••-•••-••••
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SCRI Oncology Partners ( Site 7000)
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-••••
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Saint Elizabeth Medical Center Edgewood ( Site 0112)
RECRUITINGEdgewood, Kentucky, 41017, United States
Contact Phone: •••-•••-••••
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Samsung Medical Center ( Site 1401)
RECRUITINGSeoul, 06351, South Korea
Contact Phone: •••-•••-••••
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Sanatorio Parque ( Site 1900)
RECRUITINGRosario, Santa Fe Province, S2000DSV, Argentina
Contact Phone: •••-•••-••••
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Seoul National University Hospital ( Site 1402)
RECRUITINGSeoul, 03080, South Korea
Contact Phone: •••-•••-••••
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Severance Hospital Yonsei University Health System ( Site 1403)
RECRUITINGSeoul, 03722, South Korea
Contact Phone: •••-•••-••••
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Shanghai East Hospital ( Site 1600)
RECRUITINGShanghai, Shanghai Municipality, 200000, China
Contact Phone: •••-•••-••••
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Sheba Medical Center ( Site 0601)
RECRUITINGRamat Gan, 5265601, Israel
Contact Phone: •••-•••-••••
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Sichuan Cancer hospital. ( Site 1609)
RECRUITINGChengdu, Sichuan, 610213, China
Contact Phone: •••-•••-••••
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Songklanagarind hospital ( Site 3001)
RECRUITINGHat Yai, Changwat Songkhla, 90110, Thailand
Contact Phone: •••-•••-••••
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Southern Medical University Nanfang Hospital ( Site 1608)
RECRUITINGGuangzhou, Guangdong, 510515, China
Contact Phone: •••-•••-••••
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Taizhou Hospital of Zhejiang Province ( Site 1601)
RECRUITINGTaizhou, Zhejiang, 317000, China
Contact Phone: •••-•••-••••
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The First Affiliated Hospital of Nanchang University ( Site 1610)
RECRUITINGNanchang, Jiangxi, 330209, China
Contact Phone: •••-•••-••••
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The University of Tennessee Medical Center ( Site 0120)
RECRUITINGKnoxville, Tennessee, 37920, United States
Contact Phone: •••-•••-••••
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The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 1602)
RECRUITINGHangzhou, Zhejiang, 310003, China
Contact Phone: •••-•••-••••
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Universitaetsklinikum Jena ( Site 0403)
RECRUITINGJena, Thuringia, 07747, Germany
Contact Phone: •••-•••-••••
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University of Virginia Health System ( Site 0122)
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact Phone: •••-•••-••••
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Washington University School of Medicine ( Site 0134)
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-••••
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