New hope for Hard-to-Treat prostate cancer: experimental drug combo trial opens

NCT ID NCT06353386

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This clinical trial is testing an experimental drug called opevesostat (MK-5684), either alone or combined with other cancer drugs, in people with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The study involves 220 participants and has two phases: first to find safe doses, then to see if the treatments shrink tumors or lower PSA levels. It is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Opevesostat (MK-5684), olaparib, docetaxel, cabazitaxel, fludrocortisone acetate, dexamethasone, prednisone
What this could lead to: If successful, this could lead to a new treatment option that helps control advanced prostate cancer that has stopped responding to standard hormone therapy.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 220 participants, so the treatments may not prove effective or safe in larger groups. Side effects from the drug combinations could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma Prostatic Neoplasms, Castration-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATIC NEOPLASMS, CASTRATION-RESISTANT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aalborg Universitetshospital, Syd ( Site 0503)
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Addenbrooke's Hospital ( Site 1902)
RECRUITING

Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Ankara Bilkent Şehir Hastanesi ( Site 1801)
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center-Oncology ( Site 1500)
RECRUITING

Songpagu, Seoul, 05505, South Korea
Auckland City Hospital ( Site 1333)
RECRUITING

Auckland, 1023, New Zealand
Azienda Ospedaliera Universitaria Integrata Verona - Ospedal-Centro Ricerche Cliniche di Verona ( Site 1100)
RECRUITING

Verona, 37134, Italy
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1802)
RECRUITING

Adana, 01250, Turkey (Türkiye)
Bradfordhill ( Site 0300)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CIDO SpA-Oncology ( Site 0302)
ACTIVE_NOT_RECRUITING

Temuco, Biobio, 4810218, Chile
Centre Hospitalier de l'Université de Montréal ( Site 0200)
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0207)
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1402)
RECRUITING

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland
Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1702)
RECRUITING

Taoyuan, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1704)
RECRUITING

Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0800)
ACTIVE_NOT_RECRUITING

Berlin, 10117, Germany
China Medical University Hospital ( Site 1703)
RECRUITING

Taichung, 404332, Taiwan
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0402)
RECRUITING

Bogotá, Bogota D.C., 111321, Colombia
Clinica Universidad Catolica del Maule-Oncology ( Site 0304)
RECRUITING

Talca, Maule Region, 3465584, Chile
Cork University Hospital ( Site 0902)
RECRUITING

Cork, T12 DC4A, Ireland
Docrates Syöpäsairaala ( Site 0602)
RECRUITING

Helsinki, Uusimaa, 00180, Finland
FALP ( Site 0301)
ACTIVE_NOT_RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0406)
RECRUITING

Bogotá, Bogota D.C., 110131, Colombia
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1103)
RECRUITING

Milan, Lombardy, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1102)
COMPLETED

Rome, Lazio, 00168, Italy
Fundación Valle del Lili-Oncology CIC ( Site 0403)
RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
Gallipoli Medical Research Ltd-GMRF CTU ( Site 0107)
RECRUITING

Greenslopes, Queensland, 4120, Australia
Gustave Roussy ( Site 0701)
RECRUITING

Villejuif, Île-de-France Region, 94805, France
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1800)
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0604)
RECRUITING

Helsinki, Uusimaa, 00029, Finland
Herlev and Gentofte Hospital ( Site 0501)
RECRUITING

Copenhagen, Capital Region, 2730, Denmark
Hopitaux Universitaires de Strasbourg ( Site 0700)
RECRUITING

Strasbourg, Bas-Rhin, 67200, France
Hospital Clinico San Carlos-Oncology Department ( Site 1604)
RECRUITING

Madrid, 28040, Spain
Hospital General Universitario Gregorio Marañón ( Site 1601)
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1602)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1600)
RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0702)
RECRUITING

Paris, 75015, France
IMAT S.A.S ( Site 0404)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0703)
RECRUITING

Bordeaux, Aquitaine, 33076, France
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 1603)
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1804)
RECRUITING

Istanbul, 34668, Turkey (Türkiye)
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1101)
RECRUITING

Rozzano, Milano, 20089, Italy
Jewish General Hospital ( Site 0206)
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Kyushu University Hospital ( Site 1204)
RECRUITING

Fukuoka, 812-8582, Japan
MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0020)
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Macquarie University-MQ Health Clinical Trials Unit ( Site 0108)
RECRUITING

Macquarie University, New South Wales, 2109, Australia
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 1400)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0110)
RECRUITING

Melbourne, Victoria, 3000, Australia
Pontificia Universidad Catolica de Chile ( Site 0303)
RECRUITING

Santiago, Region M. de Santiago, 832000, Chile
Queen Elizabeth Hospital Birmingham ( Site 1903)
RECRUITING

Birmingham, B15 2TH, United Kingdom
Rabin Medical Center ( Site 1001)
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus-Oncology Division ( Site 1002)
RECRUITING

Haifa, 3109601, Israel
Royal Preston Hospital-Lancashire Clinical Research Facility ( Site 1900)
RECRUITING

Preston, Lancashire, PR2 9HT, United Kingdom
Rutgers Cancer Institute of New Jersey ( Site 0033)
ACTIVE_NOT_RECRUITING

New Brunswick, New Jersey, 08903-2681, United States
Samsung Medical Center-Division of Hematology/Oncology ( Site 1501)
RECRUITING

Seoul, 06351, South Korea
Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1502)
RECRUITING

Seoul, 03722, South Korea
Sheba Medical Center ( Site 1000)
RECRUITING

Ramat Gan, 5265601, Israel
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0400)
RECRUITING

Valledupar, Cesar Department, 200001, Colombia
St. Vincent's University Hospital ( Site 0901)
RECRUITING

Dublin, Dublin, D04 T6F4, Ireland
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1803)
RECRUITING

Istanbul, 34722, Turkey (Türkiye)
Taipei Veterans General Hospital ( Site 1701)
RECRUITING

Taipei, 112, Taiwan
Tallaght University Hospital ( Site 0900)
RECRUITING

Dublin, D24 NR0A, Ireland
The Beatson West of Scotland Cancer Centre ( Site 1904)
RECRUITING

Glasgow, Glasgow City, G12 0YN, United Kingdom
The Jikei University Hospital ( Site 1202)
COMPLETED

Mitato, Tokyo, 105-8471, Japan
Toho University Sakura Medical Center ( Site 1201)
RECRUITING

Sakura, Chiba, 285-8741, Japan
UCLA Hematology/Oncology - Santa Monica ( Site 0044)
RECRUITING

Los Angeles, California, 90404, United States
UCSD Moores Cancer Center ( Site 0039)
RECRUITING

La Jolla, California, 92037, United States
Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0804)
RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Heidelberg ( Site 0805)
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Tuebingen-Urologie ( Site 0801)
RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
University College London Hospital ( Site 1905)
RECRUITING

London, London, City of, NW1 2PG, United Kingdom
University Hospitals Cleveland Medical Center ( Site 0043)
RECRUITING

Cleveland, Ohio, 44106, United States
University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0049)
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 0051)
RECRUITING

Miami, Florida, 33136, United States
Uniwersyteckie Centrum Kliniczne ( Site 1405)
RECRUITING

Gdansk, Pomeranian Voivodeship, 80-952, Poland
Vaasan Keskussairaala ( Site 0603)
RECRUITING

Vaasa, Pohjanmaa, 65130, Finland
Yokohama City University Medical Center ( Site 1203)
RECRUITING

Yokohama, Kanagawa, 232-0024, Japan
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0802)
RECRUITING

Munich, Bavaria, 81675, Germany

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