New hope for Hard-to-Treat cancers: targeted drug combo enters phase 2 trial

NCT ID NCT07209111

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 9 times

Summary

This phase 2 trial is testing a drug called calderasib (MK-1084), given alone or with cetuximab, in 150 people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the cancer shrinks or disappears and to check for side effects. Participants must have tumors that are not colorectal cancer and have progressed after standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calderasib (also known as MK-1084) and cetuximab
What this could lead to: If successful, this could provide a new treatment option for people with advanced solid tumors that have a specific KRAS G12C mutation.
What could go wrong: This is a phase 2 trial with only 150 participants, so results are still early. The drug may not work for all tumor types, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASM MALIGNANT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Adana Medical Park Seyhan Hastanesi ( Site 2706)
RECRUITING

Adana, 01140, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 2701)
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center ( Site 2302)
RECRUITING

Seoul, 05505, South Korea
Beijing Cancer hospital ( Site 1318)
RECRUITING

Beijing, Beijing Municipality, 100142, China
Bradfordhill ( Site 1201)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
Cancer Institute Hospital of JFCR ( Site 2003)
RECRUITING

Koto, Tokyo, 135-8550, Japan
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1503)
RECRUITING

Limoges, Haute-Vienne, 87042, France
Centro de Oncología de Precisión ( Site 1202)
RECRUITING

Santiago, Region M. de Santiago, 7560908, Chile
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1604)
RECRUITING

Berlin, 10117, Germany
Clinica San Carlos de Apoquindo ( Site 1203)
RECRUITING

Santiago, Region M. de Santiago, 7620002, Chile
Comprehensive Cancer Centers of Nevada ( Site 1109)
RECRUITING

Las Vegas, Nevada, 89169, United States
Emek Medical Center ( Site 1800)
RECRUITING

Afula, 1834111, Israel
Epworth Freemasons ( Site 1004)
RECRUITING

Melbourne, Victoria, 3002, Australia
European Interbalkan Medical Center-Oncology Department ( Site 1700)
RECRUITING

Thessaloniki, 57001, Greece
FALP ( Site 1200)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1900)
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1901)
RECRUITING

Roma, 00168, Italy
Fudan University Shanghai Cancer Center ( Site 1325)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Gazi Universitesi Tip Fakultesi Hastanesi ( Site 2702)
RECRUITING

Ankara, 06560, Turkey (Türkiye)
General Hospital of Athens "Laiko" ( Site 1701)
RECRUITING

Athens, Attica, 11527, Greece
Greater Baltimore Medical Center ( Site 1104)
RECRUITING

Baltimore, Maryland, 21204, United States
Hacettepe Universitesi-oncology hospital ( Site 2700)
RECRUITING

Ankara, 6230, Turkey (Türkiye)
Hadassah Medical Center ( Site 1801)
RECRUITING

Jerusalem, 9112001, Israel
Harbin Medical University Cancer Hospital ( Site 1308)
RECRUITING

Harbin, Heilongjiang, 150000, China
Haukeland universitetssykehus ( Site 2102)
RECRUITING

Bergen, Hordaland, 5021, Norway
Hopital Pitie Salpetriere ( Site 1500)
RECRUITING

Paris, 75013, France
Hospital Clinic de Barcelona ( Site 2402)
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico San Carlos ( Site 2404)
RECRUITING

Madrid, 28040, Spain
Hospital Universitari Vall d Hebron ( Site 2401)
RECRUITING

Barcelona, 08035, Spain
Hospital Virgen de la Victoria ( Site 2403)
RECRUITING

Málaga, Malaga, 29010, Spain
Hunan Cancer Hospital ( Site 1321)
RECRUITING

Changsha, Hunan, 410013, China
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1902)
RECRUITING

Rozzano, Milano, 20089, Italy
Jewish General Hospital-CRU ( Site 2900)
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Jiangsu Province Hospital ( Site 1324)
RECRUITING

Nanjing, Jiangsu, 210029, China
Jinan Central Hospital ( Site 1313)
RECRUITING

Jinan, Shandong, 250013, China
Kanagawa Cancer Center ( Site 2002)
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Karolinska Universitetssjukhuset Solna ( Site 2501)
RECRUITING

Stockholm, Stockholm County, 171 64, Sweden
Koc University Hospital ( Site 2704)
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
MTZ Clinical Research powered by Pratia ( Site 2205)
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2200)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Center Hospital ( Site 2000)
RECRUITING

Chūō, Tokyo, 104-0045, Japan
Odense Universitetshospital ( Site 1401)
RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2004)
RECRUITING

Osaka, 541-8567, Japan
Oslo universitetssykehus, Radiumhospitalet ( Site 2101)
RECRUITING

Oslo, 0379, Norway
Prince of Wales Hospital-Medical Oncology ( Site 1003)
RECRUITING

Randwick, New South Wales, 2031, Australia
Rigshospitalet ( Site 1403)
RECRUITING

Copenhagen, Capital Region, 2100, Denmark
Royal Free Hospital ( Site 2801)
RECRUITING

London, Camden, NW3 2QG, United Kingdom
Rutgers Cancer Institute of New Jersey ( Site 1100)
RECRUITING

New Brunswick, New Jersey, 08903, United States
START Midwest ( Site 1103)
RECRUITING

Grand Rapids, Michigan, 49546, United States
START Mountain Region ( Site 1106)
RECRUITING

West Valley City, Utah, 84119, United States
Sahlgrenska Universitetssjukhuset. ( Site 2502)
RECRUITING

Gothenburg, Västra Götaland County, 413 45, Sweden
Samsung Medical Center ( Site 2300)
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital ( Site 2301)
RECRUITING

Seoul, 03080, South Korea
Shanghai Chest Hospital ( Site 1300)
RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Sourasky Medical Center ( Site 1802)
RECRUITING

Tel Aviv, 6423906, Israel
Sun Yat-sen University Cancer Center ( Site 1303)
RECRUITING

Guangzhou, Guangdong, 510060, China
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 2203)
RECRUITING

Koszalin, West Pomeranian Voivodeship, 75-581, Poland
Taizhou Hospital of Zhejiang Province ( Site 1312)
RECRUITING

Linhai, Zhejiang, 317000, China
The Christie NHS Foundation Trust ( Site 2803)
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Nanchang University ( Site 1307)
RECRUITING

Nanchang, Jiangxi, 330209, China
The First Affiliated Hospital of Xiamen University ( Site 1304)
RECRUITING

Xiamen, Fujian, 361003, China
The Ottawa Hospital ( Site 2902)
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The first affiliated hospital, Sun Yat-Sen university ( Site 1329)
RECRUITING

Guangzhou, Guangdong, 510080, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1326)
RECRUITING

Wuhan, Hubei, 430000, China
Universitätsklinikum Jena ( Site 1603)
RECRUITING

Jena, Thuringia, 07747, Germany
Universitätsklinikum Leipzig ( Site 1602)
RECRUITING

Leipzig, Saxony, 04103, Germany
Virginia Cancer Specialists ( Site 1102)
RECRUITING

Fairfax, Virginia, 22031, United States
Westmead Hospital ( Site 1000)
RECRUITING

Westmead, New South Wales, 2145, Australia
Zhejiang Cancer Hospital ( Site 1311)
RECRUITING

Hangzhou, Zhejiang, 310022, China
Zhongshan Hospital,Fudan University ( Site 1301)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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