New drug cocktail aims to beat back a tough leukemia

NCT ID NCT04385290

Recruiting now Disease control Sponsor: Technische Universität Dresden Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether adding two targeted drugs, midostaurin and gemtuzumab ozogamicin, to standard chemotherapy can help people with newly diagnosed acute myeloid leukemia (AML) who have certain genetic changes. About 214 participants will receive the combination in two phases: first to find the safest dose, then to see if it improves remission and survival. The goal is to better control the disease and prevent relapse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

midostaurin and gemtuzumab ozogamicin (drugs added to standard chemotherapy)

What this could lead to

If it works, this combination could improve remission rates and delay relapse for people with certain genetic types of AML.

What could go wrong

This is an early-phase trial (phase 1/2), so safety and effectiveness are not yet proven. The added drugs may increase side effects like liver toxicity or infection risk.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

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Study contacts

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Locations

Gemeinschaftsklinikum Mittelrhein gGmbH
RECRUITING

Koblenz, 56068, Germany

Contact
Johann Wolfgang Goethe-Universität
RECRUITING

Frankfurt am Main, 60590, Germany

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Klinikum Chemnitz gGmbH
RECRUITING

Chemnitz, 09116, Germany

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Klinikum Mannheim gGmbH
RECRUITING

Mannheim, 68167, Germany

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Klinikum Nürnberg-Nord
NOT_YET_RECRUITING

Nuremberg, 90419, Germany

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Krankenhaus Barmherzige Brüder
RECRUITING

Regensburg, 93049, Germany

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LMU Klinikum, Campus Großhadern
RECRUITING

München, Bavaria, 81377, Germany

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Philipps-Universität Marburg Fachbereich Medizin
RECRUITING

Marburg, 35043, Germany

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Rems-Murr-Klinikum Winnenden
RECRUITING

Winnenden, 71364, Germany

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Robert-Bosch-Krankenhaus
RECRUITING

Stuttgart, 70376, Germany

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Rotkreuzklinikum München gGmbH
RECRUITING

München, 80634, Germany

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Universitätsklinikum Aachen
RECRUITING

Aachen, 52074, Germany

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Universitätsklinikum Augsburg
NOT_YET_RECRUITING

Augsburg, 86156, Germany

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Universitätsklinikum Dresden
RECRUITING

Dresden, 01307, Germany

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Universitätsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany

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Universitätsklinikum Halle
RECRUITING

Halle, 06120, Germany

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Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany

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Universitätsklinikum Jena
RECRUITING

Jena, 07740, Germany

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Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany

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Universitätsklinikum Münster
RECRUITING

Münster, 48149, Germany

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Universitätsklinikum Schleswig-Holstein
RECRUITING

Kiel, 24105, Germany

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