Could a sedative boost pain relief for children with broken bones?
NCT ID NCT00416039
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding a sedative (midazolam) to standard morphine painkiller helps children with arm fractures feel less pain. Sixty children aged 5 to 16 were split into two groups: one got morphine plus midazolam, the other got morphine plus a placebo. Researchers measured pain levels at different times to see if the combination worked better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
midazolam and morphine
What this could lead to
If it works, this could offer a better way to manage pain and anxiety in children with arm fractures in the emergency room.
What could go wrong
This is a small, single-center study with only 60 children, so results may not apply broadly. Adding midazolam also carries risks like drowsiness or breathing problems.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hopital Necker enfants Malade - Department of Pediatric Emergency
Paris, 75015, France