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A hidden gut condition may explain many stubborn diarrhea cases

NCT ID NCT06530836

Knowledge-focused Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

Researchers are studying 116 people with chronic watery diarrhea to see how many actually have microscopic colitis, a gut condition that standard tests often miss. Participants will give blood and stool samples and undergo a full colonoscopy with tissue biopsies from different parts of the colon. The study aims to measure how common microscopic colitis is in this group and to compare the rates of its two main types, lymphocytic and collagenous colitis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If microscopic colitis proves to be a common cause of chronic diarrhea, doctors may diagnose it more often and treat it sooner.
What could go wrong
This study only observes and measures, so it cannot prove what causes the diarrhea. The results may not apply to all patients with chronic diarrhea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

116 people

The number who actually took part.

Started

Jan 2024

Finished

Jan 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presented with chronic diarrhea in the outpatient clinic or the inward in the Gastroenterology and Hepatology unit in the Internal Medicine Department, Zagazig University hospitals from January 2024 to January 2025

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with chronic watery diarrhea Exclusion Criteria: * Infectious colitis. * Inflammatory bowel diseases (ulcerative colitis, Crohn's disease, and indeterminate colitis). * Systemic disease associated with chronic diarrhea, e.g. Diabetes mellitus and Thyroid disease. * Drugs causing chronic diarrhea, e.g. antibiotics, antidepressants, and angiotensin-converting enzyme inhibitors. * Chronic diarrhea of decreased digestion as in pancreatic insufficiency and bile acid deficiency.

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Conditions

The condition(s) this trial relates to.

chronic diarrheal disease microscopic colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic diarrhea Microscopic colitis

Contacts and locations

Locations

  • Zagazig University Hospital

    Zagazig, Sharqia Province, 44519, Egypt

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