New drug combo aims to tackle Hard-to-Treat myeloma
NCT ID NCT06645678
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of two drugs, mezigdomide and elranatamab, in 75 people with relapsed or refractory multiple myeloma (a blood cancer that has come back or stopped responding to treatment). The goal is to see how well the combination works and how safe it is. Participants will receive injections of elranatamab along with oral mezigdomide, with doses adjusted based on response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mezigdomide and elranatamab
What this could lead to
If successful, this combination could offer a new treatment option for patients with multiple myeloma that has stopped responding to other therapies.
What could go wrong
This is an early-phase trial (Phase I/II) with only 75 participants, so results may not apply broadly. Side effects from the drugs could be significant, and the combination may not work better than existing treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center, University of Ulsan College of Medicine
RECRUITINGSeoul, South Korea
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Chonnam National University Hwasun Hospital
RECRUITINGHwasun, South Korea
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National University Hospital (NUH)
RECRUITINGSingapore, Singapore
Contact
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Samsung Medical Center, Sungkyunkwan University School of Medicine
RECRUITINGSeoul, South Korea
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Seoul National University Hospital
NOT_YET_RECRUITINGSeoul, South Korea
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Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
RECRUITINGSeoul, South Korea
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Singhealth Duke NUS blood cancer center
RECRUITINGSingapore, Singapore
Contact