Diabetes drug metformin tested as cancer booster in new trial

NCT ID NCT07098299

Recruiting now Disease control Sponsor: Barbara Ann Karmanos Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This early-phase study tests whether adding metformin (a common diabetes drug) to standard chemotherapy or immunotherapy is safe for people with advanced solid tumors. About 60 participants will take metformin alone for two weeks, then continue it alongside their regular cancer treatment. The goal is to find the highest safe dose and track any side effects.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Karmanos Cancer Institute at McLaren Bay Region
RECRUITING

Bay City, Michigan, 48706, United States
Karmanos Cancer Institute at McLaren Central Michigan, Morey Cancer Center
RECRUITING

Mount Pleasant, Michigan, 48858, United States
Karmanos Cancer Institute at McLaren Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States
Karmanos Cancer Institute at McLaren Flint
RECRUITING

Flint, Michigan, 48532, United States
Karmanos Cancer Institute at McLaren Greater Lansing
RECRUITING

Lansing, Michigan, 48910, United States
Karmanos Cancer Institute at McLaren Lapeer Region
RECRUITING

Lapeer, Michigan, 48466, United States
Karmanos Cancer Institute at McLaren Macomb
RECRUITING

Macomb, Michigan, 48043, United States
Karmanos Cancer Institute at McLaren Northern Michigan, Petoskey
RECRUITING

Petoskey, Michigan, 49770, United States
Karmanos Cancer Institute at McLaren Port Huron
RECRUITING

Port Huron, Michigan, 48060, United States

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