Radiation boost for cancer immunotherapy?

NCT ID NCT03304639

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is testing if adding a short, precise course of radiation (SBRT) to an immunotherapy drug (pembrolizumab) works better than the drug alone for people with advanced Merkel cell carcinoma, a rare and aggressive skin cancer. It aims to see if the combination helps control the cancer for longer. The trial has finished enrolling a small group of participants and is in its second phase of testing.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
AdventHealth Littleton

Littleton, Colorado, 80122, United States
AdventHealth Parker

Parker, Colorado, 80138, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Centerpoint Medical Center LLC

Independence, Missouri, 64057, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Delaware Radiation Oncology

Delaware, Ohio, 43015, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Dublin Methodist Hospital

Dublin, Ohio, 43016, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Kansas Institute of Medicine Cancer and Blood Center

Lenexa, Kansas, 66219, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Medical Center of Baton Rouge

Baton Rouge, Louisiana, 70816, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital

Chattanooga, Tennessee, 37404, United States
Menorah Medical Center

Overland Park, Kansas, 66209, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States
Methodist West Hospital

West Des Moines, Iowa, 50266-7700, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Minimally Invasive Surgery Hospital

Lenexa, Kansas, 66219, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180, United States
Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809, United States
Ochsner High Grove

Baton Rouge, Louisiana, 70836, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States
OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148, United States
OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Seven Hills

Henderson, Nevada, 89052, United States
Overlake Medical Center

Bellevue, Washington, 98004, United States
PCR Oncology

Arroyo Grande, California, 93420, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Radiation Oncology Associates

Reno, Nevada, 89509, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Research Medical Center

Kansas City, Missouri, 64132, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
Rush-Copley Medical Center

Aurora, Illinois, 60504, United States
SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States
Saint Michael Cancer Center

Silverdale, Washington, 98383, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Valley Medical Center

Renton, Washington, 98055, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED MERKEL CELL CARCINOMA CLINICAL STAGE III CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 CLINICAL STAGE IV CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 METASTATIC MERKEL CELL CARCINOMA PATHOLOGIC STAGE III CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IIIA CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IIIB CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IV CUTANEOUS MERKEL CELL CARCINOMA AJCC V8