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Period phase could skew heart test results, study finds

NCT ID NCT05985980

Knowledge-focused Sponsor: Istanbul Medeniyet University Source: ClinicalTrials.gov ↗

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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 47 premenopausal women to see if the phase of their menstrual cycle changes the results of an exercise treadmill test (a heart stress test). Researchers compared test results from the early and late follicular phases, when estrogen levels are low and high, to understand why women often get false positive results. The goal was to learn more about the biological causes behind these misleading test outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

47 people

The number who actually took part.

Started

Mar 2023

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of premenopausal women who applied to the outpatient clinic with chest pain. ETT is ordered as a routine diagnostic workup. Two ETTs are performed on each participant. The early follicular phase ETT is planned on the 3rd day of menstrual bleeding, while the menstrual bleeding continues. The late follicular phase ETT is planned on the 3rd day after the menstrual bleeding ends. Hormone levels are measured before each ETT to ascertain the phase of the menstrual cycle.

Ages

20 to 55 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The inclusion criteria are: 1. Premenopausal female patients with regular menstrual cycles, 2. Ages between 20-55 years, 3. Patients have been seen in the cardiology clinic by a cardiologist for the symptoms of chest pain with a clinical suspicion of angina or angina equivalent. 4. A cardiologist has ordered ETT as a diagnostic test independent of the study protocol 5. Patients can understand and sign the informed consent. The exclusion criteria are: The exclusion criteria are: 1. Women with menopause or menopause-related symptoms or menstrual cycle irregularity or use of hormonal therapy or oral contraceptives, current pregnancy 2. Patients with a history of CAD, secondary or uncontrolled hypertension, valvular heart disease, cardiac arrhythmia or heart failure, pericarditis or myocarditis. 3. Left ventricular hypertrophy on echocardiography, abnormal systolic or diastolic function or wall motion abnormality on echocardiography. 4. History of cancer, stage ≥ 3 kidney failure, liver failure, history of psychiatric illness, history of recent infection. 5. Pre-existing ECG abnormality that would confound the interpretation during the ETT (baseline ECG was considered abnormal ın the presence of the following findings: prolonged QT interval, chamber hypertrophy, alterations in the ST-T waves, any degree of heart block, T-wave abnormalities, premature ventricular contractions (PVCs), right bundle branch block (RBBB), left bundle branch block (LBBB), left or right axis deviation, or any abnormal rhythm other than normal sinus rhythm). 6. Patients who cannot tolerate Bruce protocol in the first ETT. 7. Lack of ability or mental capacity to understand the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exercise treadmill Menstrual cycle

Contacts and locations

Locations

  • Istanbul Medeniyet University Hospital, Goztepe

    Istanbul, 34722, Turkey (Türkiye)

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