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New hope for rare mitochondrial disease: TTI-0102 enters phase 2 trial

NCT ID NCT06644534

Recruiting now Disease control Sponsor: Thiogenesis Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 25 times

Summary

This study tests an oral drug called TTI-0102 in 12 people aged 16–60 with MELAS, a rare genetic disorder that causes muscle weakness, lactic acid buildup, and stroke-like episodes. Participants receive either TTI-0102 or a placebo for 6 months to see if the drug improves walking distance, fatigue, and quality of life. The goal is to manage symptoms and slow disease progression, not to cure the condition.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Angers University Hospital Center (CHU Angers)

    RECRUITING

    Angers, 49100, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Radboud University Medical Center

    RECRUITING

    Nijmegen, 6500 HB, Netherlands

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

MELAS SYNDROME MITOCHONDRIAL ENCEPHALOMYOPATHY, LACTIC ACIDOSIS AND STROKE-LIKE EPISODES (MELAS)