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Researchers track rare mitochondrial disorder to unlock its secrets

NCT ID NCT01532791

Recruiting now Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Feb 01, 2026 · Last updated May 25, 2026 · Updated 14 times

Summary

This study follows people who carry a specific genetic change (m.3243A>G) that can cause a condition called MELAS, which affects the brain and muscles. Researchers will use brain scans, blood tests, and physical exams to track how symptoms like migraines, hearing loss, and balance problems change over time. No treatments are given—the goal is to learn more about the disease to help develop future therapies. The study includes carriers, their maternal relatives, and unrelated family members as controls.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Columbia University

    RECRUITING

    New York, New York, 10032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

MELAS OR M.3243 A>G MITOCHONDRIAL DNA MUTATION CARRIER MELAS OR M.3243 A>G MITOCHONDRIAL DNA MUTATION CARRIER