Personalized cancer vaccine enters final testing to stop deadly skin Cancer's return

NCT ID NCT05933577

Summary

This study is testing whether adding a personalized mRNA vaccine (V940) to a standard immunotherapy drug (pembrolizumab) is better at preventing melanoma from coming back after surgery than the drug alone. It involves about 1,089 people with high-risk melanoma who have had their cancer surgically removed. The goal is to see if this combination treatment can help people live longer without their cancer returning.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AO Santa Maria della Misericordia ( Site 1403)

    Perugia, Umbria, 06129, Italy

  • AZ Groeninge Campus Kennedylaan-Oncology ( Site 3401)

    Kortrijk, West-Vlaanderen, 8500, Belgium

  • Aalborg Universitetshospital, Syd ( Site 3302)

    Aalborg, North Denmark, 9000, Denmark

  • Acibadem Universitesi Atakent Hastanesi-Medical Oncology ( Site 3008)

    Istanbul, 34303, Turkey (Türkiye)

  • Addenbrooke's Hospital ( Site 1800)

    Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom

  • Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 3002)

    Ankara, 06800, Turkey (Türkiye)

  • Assistance Publique Hôpitaux de Marseille - Hôpital de la Ti-Service de Dermatologie et Cancérologi ( Site 1203)

    Marseille, Bouches-du-Rhone, 13385, France

  • Atlantic Health System ( Site 1925)

    Morristown, New Jersey, 07960, United States

  • Azienda Ospedaliero Universitaria Senese-U.O.C. Immunoterapia Oncologica ( Site 1402)

    Siena, Tuscany, 53100, Italy

  • BC Cancer Vancouver-Clinical Trials Unit ( Site 1106)

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Beth Israel Deaconess Medical Center ( Site 1957)

    Boston, Massachusetts, 02215, United States

  • Bialostockie Centrum Onkologii ( Site 2905)

    Bialystok, Podlaskie Voivodeship, 15-027, Poland

  • Bioclinic Thessalonikis Private Clinic Single Member S.A.-Oncology ( Site 3703)

    Thessaloniki, Central Macedonia, 546 22, Greece

  • Bradfordhill ( Site 2401)

    Santiago, Region M. de Santiago, 8420383, Chile

  • Bristol Haematology and Oncology Centre ( Site 1811)

    Bristol, Bristol, City of, BS2 8ED, United Kingdom

  • CHU Besançon ( Site 1209)

    Besançon, Doubs, 25030, France

  • CHU d'Amiens-Picardie - Hôpital Sud-Dermatologie ( Site 1208)

    Amiens, Somme, 80054, France

  • CHU de Bordeaux Hop St ANDRE-Service de Dermatologie ( Site 1204)

    Bordeaux, Gironde, 33075, France

  • Cancer and Hematology Centers of Western Michigan ( Site 1932)

    Grand Rapids, Michigan, 49503, United States

  • Cape Town Oncology Trials ( Site 4100)

    Cape Town, Western Cape, 7570, South Africa

  • Capital, Coast and Hutt Valley District - Wellington Regional Hospital ( Site 1502)

    Newtown, Wellington Region, 6021, New Zealand

  • Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 1206)

    Rennes, Ille-et-Vilaine, 35042, France

  • Centre Georges François Leclerc ( Site 1210)

    Dijon, Cote-d Or, 21079, France

  • Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 1211)

    Nice, Alpes-Maritimes, 06200, France

  • Centre Hospitalier de l'Université de Montréal-Unité de Recherche Clinique en Oncologie et Hématolo ( Site 1100)

    Montreal, Quebec, H2X 0X9, Canada

  • Centre intégré de cancérologie du CHU de Québec Université L-Hemato-Oncology ( Site 1101)

    Québec, Quebec, G1J 1Z4, Canada

  • Centro Avançado de Tratamento Oncológico- CENANTRON ( Site 2303)

    Belo Horizonte, Minas Gerais, 30130-090, Brazil

  • Centro Privado de RMI Río Cuarto S.A. II ( Site 2201)

    Río Cuarto, Córdoba Province, X5800ALB, Argentina

  • Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2908)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-796, Poland

  • Chang Gung Medical Foundation-Linkou Branch ( Site 4003)

    Taoyuan District, 33305, Taiwan

  • Chang Gung Memorial Hospital at Kaohsiung ( Site 4000)

    Kaohsiung City, 83301, Taiwan

  • Charité Universitaetsmedizin Berlin - Campus Mitte-Hauttumorcentrum Charité (HTCC) ( Site 1302)

    Berlin, 10115, Germany

  • Chungnam national university hospital-Department of Internal Medicine ( Site 3903)

    Daejeon, Taejon-Kwangyokshi, 35015, South Korea

  • Clinica Adventista Belgrano-Oncology ( Site 2204)

    Caba., Buenos Aires, C1430EGF, Argentina

  • Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 2500)

    Bogotá, Bogota D.C., 111321, Colombia

  • Clinica Somer-Unidad de Investigacion y Docencia ( Site 2506)

    Rionegro, Antioquia, 054040, Colombia

  • Clínica UC San Carlos de Apoquindo-Hemato-Oncology ( Site 2402)

    Santiago, Region M. de Santiago, 7620002, Chile

  • Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 1908)

    New York, New York, 10032, United States

  • Cross Cancer Institute ( Site 1104)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dana-Farber Cancer Institute ( Site 1956)

    Boston, Massachusetts, 02215, United States

  • Duke Cancer Institute ( Site 1911)

    Durham, North Carolina, 27710, United States

  • Ege University Medical Faculty Hospital ( Site 3011)

    Izmir, 35100, Turkey (Türkiye)

  • Emek Medical Center ( Site 2003)

    Afula, 1834111, Israel

  • European Interbalkan Medical Center-Oncology Department ( Site 3702)

    Thessaloniki, 570 01, Greece

  • FALP-UIDO ( Site 2400)

    Santiago, Region M. de Santiago, 7500921, Chile

  • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1401)

    Milan, Lombardy, 20133, Italy

  • Fred Hutchinson Cancer Center ( Site 1901)

    Seattle, Washington, 98109, United States

  • Fundación Valle del Lili ( Site 2505)

    Cali, Valle del Cauca Department, 760032, Colombia

  • General Hospital of Athens "Laiko"-First Department of Internal Medicine ( Site 3700)

    Athens, Attica, 115 26, Greece

  • Gustave Roussy-Dermatologie ( Site 1201)

    Villejuif, Val-de-Marne, 94800, France

  • H.R.U Málaga - Hospital General-Oncology ( Site 1605)

    Málaga, Malaga, 29011, Spain

  • HOSPITAL CLINICO DE VALENCIA ( Site 1604)

    Valencia, Valenciana, Comunitat, 46010, Spain

  • HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 1600)

    Barcelona, Catalonia, 08036, Spain

  • HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1603)

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hacettepe Universite Hastaneleri ( Site 3006)

    Ankara, 06230, Turkey (Türkiye)

  • Hadassah Medical Center ( Site 2004)

    Jerusalem, 9112001, Israel

  • Harbour Cancer & Wellness ( Site 1500)

    Auckland, 1023, New Zealand

  • Herlev and Gentofte Hospital ( Site 3301)

    Copenhagen, Capital Region, 2730, Denmark

  • Highlands Oncology Group ( Site 1943)

    Springdale, Arkansas, 72762, United States

  • Hopital Claude Huriez - CHU de Lille ( Site 1207)

    Lille, Nord, 59037, France

  • Hospital Aleman ( Site 2200)

    Buenos Aires, C1118AAT, Argentina

  • Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 2202)

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina

  • Hospital Nossa Senhora da Conceição ( Site 2309)

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1601)

    Barcelona, 08035, Spain

  • Hospital Universitario Ramón y Cajal ( Site 1602)

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 1905)

    Philadelphia, Pennsylvania, 19104, United States

  • Hôpital Saint-Louis ( Site 1200)

    Paris, 75010, France

  • I.E.U. Medical Point Hastanesi-Oncology ( Site 3005)

    Izmir, 35575, Turkey (Türkiye)

  • ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 2300)

    São Paulo, 01246-000, Brazil

  • IMAT S.A.S ( Site 2503)

    Montería, Departamento de Córdoba, 230002, Colombia

  • Inova Schar Cancer Institute ( Site 1900)

    Fairfax, Virginia, 22031, United States

  • Instituto Alexander Fleming-Alexander Fleming ( Site 2203)

    Buenos Aires, Buenos Aires F.D., 1426ANZ, Argentina

  • Instituto Nacional de Câncer - INCA-Pesquisa Clinica HC II ( Site 2305)

    Rio de Janeiro, 20220-410, Brazil

  • Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3601)

    Lisbon, Lisbon District, 1099-023, Portugal

  • Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3604)

    Porto, 4200-072, Portugal

  • Istituto Europeo di Oncologia IRCCS ( Site 1404)

    Milan, Lombardy, 20141, Italy

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale-s.c. melanoma, immunoterapia oncologica e terapi ( Site 1400)

    Naples, 80131, Italy

  • Johannes Wesling Klinikum Minden-Skin Cancer Center Minden ( Site 1301)

    Minden, North Rhine-Westphalia, 32429, Germany

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 1944)

    Hackensack, New Jersey, 07601, United States

  • Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Melanoma ( Site 1912)

    Baltimore, Maryland, 21287, United States

  • Kantonsspital Graubünden-Medizin ( Site 1703)

    Chur, Kanton Graubünden, 7000, Switzerland

  • Klinik und Poliklinik für Dermatologie und Allergologie-Dermato-oncology ( Site 1315)

    München, Bavaria, 80337, Germany

  • Kyungpook National University Chilgok Hospital-Hematology/oncology ( Site 3904)

    Daegu, Taegu-Kwangyokshi, 41404, South Korea

  • Massachusetts General Hospital ( Site 1927)

    Boston, Massachusetts, 02114, United States

  • Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2903)

    Siedlce, Masovian Voivodeship, 08-110, Poland

  • Medical Oncology Centre of Rosebank ( Site 4106)

    Johannesburg, Gauteng, 2196, South Africa

  • Medical University of South Carolina-Hollings Cancer Center ( Site 1934)

    Charleston, South Carolina, 29425, United States

  • Melanoma Institute Australia-Clinical Trials Unit ( Site 1000)

    Wollstonecraft, New South Wales, 2065, Australia

  • Memorial Ankara Hastanesi-Medical Oncology ( Site 3010)

    Ankara, 06520, Turkey (Türkiye)

  • Memorial Sloan Kettering Cancer Center ( Site 1914)

    New York, New York, 10065, United States

  • Metropolitan Hospital-A' Oncology Dpt ( Site 3701)

    Neo Faliro, Attica, 185 47, Greece

  • Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center ( Site 1945)

    Tampa, Florida, 33612, United States

  • NYU Langone Health-Perlmutter Cancer Center ( Site 1917)

    New York, New York, 10016, United States

  • Nagoya University Hospital ( Site 4201)

    Nagoya, Aichi-ken, 466-8560, Japan

  • Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2907)

    Gliwice, Silesian Voivodeship, 44-101, Poland

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2900)

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Center Hospital ( Site 4200)

    Chūō, Tokyo, 104-0045, Japan

  • National Cheng Kung University Hospital-Clinical Trial Center ( Site 4004)

    Tainan, 704, Taiwan

  • National Taiwan University Hospital ( Site 4001)

    Taipei, 10002, Taiwan

  • Norfolk and Norwich University Hospitals NHS Foundation Trust ( Site 1813)

    Cringleford, England, NR4 7UY, United Kingdom

  • Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 1950)

    Marietta, Georgia, 30060, United States

  • ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 2302)

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Odense Universitetshospital ( Site 3300)

    Odense C, Region Syddanmark, 5000, Denmark

  • One Clinical Research ( Site 1002)

    Nedlands, Western Australia, 6009, Australia

  • Orlando Health Cancer Institute ( Site 1937)

    Orlando, Florida, 32806, United States

  • Paula Fox Melanoma & Cancer Centre ( Site 1004)

    Melbourne, Victoria, 3004, Australia

  • Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 1958)

    Mineola, New York, 11501, United States

  • Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 1005)

    Melbourne, Victoria, 3000, Australia

  • Princess Alexandra Hospital ( Site 1003)

    Brisbane, Queensland, 4102, Australia

  • Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 1102)

    Toronto, Ontario, M5G 2M9, Canada

  • ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 1804)

    London, London, City of, SW3 6JJ, United Kingdom

  • Rabin Medical Center ( Site 2000)

    Petah Tikva, 4941492, Israel

  • SCRI Oncology Partners ( Site 1910)

    Nashville, Tennessee, 37203, United States

  • SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1306)

    Gera, Thuringia, 07548, Germany

  • Sahlgrenska Universitetssjukhuset ( Site 3200)

    Gothenburg, Västra Götaland County, 413 45, Sweden

  • Samsung Medical Center-Division of Hematology/Oncology ( Site 3900)

    Seoul, 06351, South Korea

  • Sanatorio Finochietto ( Site 2205)

    Buenos Aires, C1187AAN, Argentina

  • Sanford Cancer Center ( Site 1951)

    Sioux Falls, South Dakota, 57104, United States

  • Seoul National University Hospital-Oncology ( Site 3902)

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System-Medical oncology ( Site 3901)

    Seoul, 03722, South Korea

  • Sheba Medical Center ( Site 2001)

    Ramat Gan, 5265601, Israel

  • Shizuoka Cancer Center ( Site 4202)

    Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan

  • Skånes Universitetssjukhus Lund ( Site 3201)

    Lund, Skåne County, 22185, Sweden

  • St James's University Hospital-Leeds Cancer Centre ( Site 1808)

    Leeds, LS9 7TF, United Kingdom

  • Sunnybrook Research Institute ( Site 1103)

    Toronto, Ontario, M4N 3M5, Canada

  • Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 2902)

    Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3003)

    Istanbul, 34722, Turkey (Türkiye)

  • Texas Oncology - Austin ( Site 1903)

    Austin, Texas, 78731, United States

  • Texas Oncology - Dallas (Sammons) ( Site 1902)

    Dallas, Texas, 75246, United States

  • The Christie NHS Foundation Trust ( Site 1814)

    Manchester, m20 4bx, United Kingdom

  • The Churchill Hospital ( Site 1805)

    Oxford, Oxfordshire, OX3 7LE, United Kingdom

  • UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1918)

    Los Angeles, California, 90095, United States

  • UCSF Medical Center at Mission Bay ( Site 1929)

    San Francisco, California, 94158, United States

  • UPMC Hillman Cancer Center ( Site 1909)

    Pittsburgh, Pennsylvania, 15232, United States

  • UZ Brussel-Medische oncologie ( Site 3405)

    Brussels, Bruxelles-Capitale, Region de, 1090, Belgium

  • UZ Gent ( Site 3403)

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • UZ Leuven ( Site 3400)

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3602)

    Lisbon, 1449-005, Portugal

  • Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3603)

    Lisbon, 1649-035, Portugal

  • Universitaetsklinikum Augsburg ( Site 1312)

    Augsburg, Bavaria, 86156, Germany

  • Universitaetsklinikum Essen-Klinik für Dermatologie, Venerologie und Allergologie ( Site 1300)

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitaetsklinikum Hamburg-Eppendorf ( Site 1309)

    Hamburg, 20246, Germany

  • Universitaetsklinikum Koeln ( Site 1307)

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitaetsklinikum des Saarlandes ( Site 1313)

    Homburg, Saarland, 66424, Germany

  • University College London Hospital ( Site 1807)

    London, London, City of, NW1 2PG, United Kingdom

  • University of Iowa-Holden Comprehensive Cancer Center ( Site 1935)

    Iowa City, Iowa, 52242, United States

  • University of Michigan ( Site 1915)

    Ann Arbor, Michigan, 48109, United States

  • University of North Carolina Medical Center-Lineberger Comprehensive Cancer Center ( Site 1949)

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas MD Anderson Cancer Center ( Site 1920)

    Houston, Texas, 77030, United States

  • UniversitätsSpital Zürich-Dermatology ( Site 1700)

    Zürich Flughafen, Canton of Zurich, 8058, Switzerland

  • Universitätsmedizin Göttingen - Georg-August-Universität-Dermatology ( Site 1308)

    Göttingen, Lower Saxony, 37075, Germany

  • Universitätsmedizin Mannheim ( Site 1305)

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Universitätsmedizin Rostock-Klinik und Poliklinik für Dermatologie und Venerologie ( Site 1310)

    Rostock, Mecklenburg-Vorpommern, 18057, Germany

  • Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2909)

    Poznan, Greater Poland Voivodeship, 60-569, Poland

  • Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site 2906)

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Valley Health Systems - Ridgewood Campus ( Site 1947)

    Ridgewood, New Jersey, 07450, United States

  • Western General Hospital ( Site 1806)

    Edinburgh, Midlothian, EH4 2XU, United Kingdom

  • Westmead Hospital ( Site 1001)

    Westmead, New South Wales, 2145, Australia

  • Wilgers Oncology Centre ( Site 4103)

    Pretoria, Gauteng, 0040, South Africa

  • William Osler Health System ( Site 1105)

    Brampton, Ontario, L6R 3J7, Canada

  • Winship Cancer Institute of Emory University ( Site 1940)

    Atlanta, Georgia, 30322, United States

  • Yale-New Haven Hospital-Yale Cancer Center ( Site 1933)

    New Haven, Connecticut, 06510, United States

  • Zachodniopomorskie Centrum Onkologii ( Site 2904)

    Szczecin, West Pomeranian Voivodeship, 71-730, Poland

  • Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3402)

    Genk, Limburg, 3600, Belgium

  • centre hospitalier lyon sud-Service de dermatologie ( Site 1202)

    Pierre-Bénite, Rhone, 69310, France

Conditions

Explore the condition pages connected to this study.