New drug combo tested for Tough-to-Treat skin cancer
NCT ID NCT05926960
Summary
This study tested two different combinations of cancer drugs for people with advanced melanoma that had a specific genetic change (BRAF mutation) and had stopped responding to a common first-line immunotherapy. Participants received either a three-drug combination (encorafenib, binimetinib, and pembrolizumab) or a two-drug combination (ipilimumab and nivolumab). The main goal was to see which treatment was better at shrinking tumors and controlling the cancer.
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Contacts and locations
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Locations
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A.O.U. Policlinico Paolo Giaccone
Palermo, Sicily, 90127, Italy
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AO Santa Maria della Misericordia
Perugia, Umbria, 06132, Italy
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Azienda Ospedaliero Universitaria Senese
Siena, Tuscany, 53100, Italy
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Fachklinik Hornheide
Münster, North Rhine-Westphalia, 48157, Germany
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital General Universitario de Valencia
Valencia, Valenciana, Comunitat, 46014, Spain
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Hospital Germans Trias i Pujol
Badalona, Barcelona [barcelona], 08916, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Institut Català d'Oncologia - L'Hospitalet
L'Hospitalet de Llobregat, Catalunya [cataluña], 08908, Spain
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Istituto Europeo di Oncologia IRCCS
Milan, 20141, Italy
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Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, 80131, Italy
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Istituto Nazionale Tumori Regina Elena
Rome, ROMA, 00144, Italy
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Istituto Oncologico Veneto IRCCS
Padua, Veneto, 35128, Italy
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Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, Torino, 10060, Italy
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Narodny onkologicky ustav
Bratislava, 833 10, Slovakia
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Neovizia, s.r.o.
Bratislava, 85101, Slovakia
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Pratia MCM Krakow
Krakow, 30-727, Poland
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Universitaetsklinikum Essen
Essen, North Rhine-Westphalia, 45147, Germany
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Universitaetsklinikum Tuebingen
Tübingen, Baden-Wurttemberg, 72076, Germany
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Universitätsklinikum Schleswig-Holstein
Lübeck, Schleswig-Holstein, 23538, Germany
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Universitätsmedizin Johannes Gutenberg Universität Mainz
Mainz, Rhineland-Palatinate, 55131, Germany
Conditions
Explore the condition pages connected to this study.