New hope for advanced melanoma: drug combos tested in major study
NCT ID NCT04305054
First seen Apr 10, 2026 · Last updated May 13, 2026 · Updated 4 times
Summary
This study is for people with advanced melanoma that hasn't been treated yet. Researchers are testing whether adding other drugs to pembrolizumab (an immunotherapy) can shrink tumors or stop them from growing. The study involves about 315 participants and focuses on safety and how well the tumors respond. It is not a cure, but aims to better control the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.P.H. Paris, Hopital Saint Louis ( Site 2107)
Paris, 75010, France
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Bradfordhill ( Site 2252)
Santiago, Region M. de Santiago, 8420383, Chile
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C.H. Lyon Sud ( Site 2102)
Pierre-Bénite, Rhone, 69495, France
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CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE ( Site 2865)
Port Elizabeth, Eastern Cape, 6055, South Africa
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CHU de Bordeaux- Hopital Saint Andre ( Site 2108)
Bordeaux, Gironde, 33075, France
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CHUV Centre Hospitalier Universitaire Vaudois ( Site 2602)
Lausanne, Canton of Vaud, 1011, Switzerland
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CIDO SpA-Oncology ( Site 2256)
Temuco, Araucania, 4810218, Chile
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Calvary Mater Newcastle-Medical Oncology ( Site 2404)
Waratah, New South Wales, 2298, Australia
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Cape Town Oncology Trials ( Site 2864)
Cape Town, Western Cape, 7570, South Africa
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Chaim Sheba Medical Center ( Site 2701)
Ramat Gan, 5265601, Israel
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Clinica Adventista Belgrano-Oncology ( Site 2242)
Caba., Buenos Aires, C1430EGF, Argentina
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Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 2261)
Bogotá, Bogota D.C., 111321, Colombia
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Duke Cancer Institute ( Site 2005)
Durham, North Carolina, 27710, United States
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European Interbalkan Medical Center-Oncology Department ( Site 2211)
Thessaloniki, 570 01, Greece
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FALP-UIDO ( Site 2251)
Santiago, Region M. de Santiago, 7500921, Chile
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Fiona Stanley Hospital ( Site 2401)
Murdoch, Western Australia, 6150, Australia
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Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2399)
Milan, 20133, Italy
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Fundación Valle del Lili ( Site 2265)
Cali, Valle del Cauca Department, 760032, Colombia
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General Hospital of Athens "Laiko"-First Department of Internal Medicine ( Site 2212)
Athens, Attica, 115 26, Greece
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Gustave Roussy ( Site 2101)
Villejuif, Île-de-France Region, 94805, France
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HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2801)
Barcelona, Catalonia, 08036, Spain
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HaEmek Medical Center ( Site 2703)
Afula, 1834111, Israel
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Hadassah Ein Karem Jerusalem ( Site 2702)
Jerusalem, 9112001, Israel
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Hopital La Timone ( Site 2103)
Marseille, Bouches-du-Rhone, 13005, France
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Hospital Universitario Ramón y Cajal ( Site 2802)
Madrid, Madrid, Comunidad de, 28034, Spain
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Hôpitaux Universitaires de Genève (HUG)-Oncology ( Site 2603)
Geneva, Canton of Geneva, 1211, Switzerland
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IC La Serena Research ( Site 2254)
La Serena, Coquimbo Region, 1720430, Chile
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Inova Schar Cancer Institute ( Site 2011)
Fairfax, Virginia, 22031, United States
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Institut Claudius Regaud ( Site 2105)
Toulouse, Haute-Garonne, 31059, France
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Instituto Alexander Fleming-Alexander Fleming ( Site 2243)
Buenos Aires, Buenos Aires F.D., 1426ANZ, Argentina
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Istituto Europeo di Oncologia ( Site 2301)
Milan, 20141, Italy
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Istituto Nazionale Tumori Fondazione Pascale ( Site 2302)
Naples, 80131, Italy
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Istituto Oncologico Veneto IRCCS ( Site 2355)
Padova, 35128, Italy
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LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2861)
Pretoria, Gauteng, 0181, South Africa
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Martha Morehouse Tower ( Site 2020)
Columbus, Ohio, 43221, United States
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Mays Cancer Center ( Site 2025)
San Antonio, Texas, 78229, United States
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Melanoma Institute Australia ( Site 2402)
Wollstonecraft, New South Wales, 2065, Australia
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NYU Clinical Cancer Center ( Site 2002)
New York, New York, 10016, United States
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2233)
Warsaw, Masovian Voivodeship, 02-781, Poland
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Oncovida ( Site 2257)
Santiago, Region M. de Santiago, 7500994, Chile
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Oregon Health & Science University ( Site 2013)
Portland, Oregon, 97239, United States
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Policlinico Le Scotte - A.O. Senese ( Site 2377)
Siena, 53100, Italy
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Providence Saint John's Health Center ( Site 2010)
Santa Monica, California, 90404, United States
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R.J. Zuckerberg Cancer Center ( Site 2032)
Lake Success, New York, 11042, United States
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Rabin Medical Center-Oncology ( Site 2705)
Petah Tikva, 4941492, Israel
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Rambam Health Care Campus-Oncology ( Site 2704)
Haifa, 3109601, Israel
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Sanatorio Finochietto ( Site 2245)
Buenos Aires, C1187AAN, Argentina
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Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2863)
Sandton, Gauteng, 2196, South Africa
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 2022)
Baltimore, Maryland, 21287, United States
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Steve Biko Academic Hospital-Medical Oncology ( Site 2862)
Pretoria, Gauteng, 0002, South Africa
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Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 2221)
Szeged, Csongrád megye, 6720, Hungary
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Tasman Oncology Research Pty Ltd ( Site 2403)
Southport, Queensland, 4120, Australia
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The Angeles Clinic and Research Institute ( Site 2009)
Los Angeles, California, 90025, United States
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UCLA Hematology & Oncology ( Site 2004)
Los Angeles, California, 90095, United States
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Universitaetsspital Zuerich ( Site 2601)
Zuerich Flughafen, Canton of Zurich, 8058, Switzerland
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University of Colorado, Anschutz Cancer Pavilion ( Site 2012)
Aurora, Colorado, 80045, United States
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University of Florida College of Medicine-UF Health Cancer Center/Clinical Trials Office ( Site 2026)
Gainesville, Florida, 32608, United States
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University of Pennsylvania Abramson Cancer Center ( Site 2008)
Philadelphia, Pennsylvania, 19104, United States
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Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 2231)
Gdansk, Pomeranian Voivodeship, 80-952, Poland
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West Cancer Center - East Campus ( Site 2014)
Germantown, Tennessee, 38138, United States
Conditions
Explore the condition pages connected to this study.