Triple-Threat attack on deadly skin cancer halted in final trial phase

NCT ID NCT02967692

Terminated Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial aimed to see if adding a new immunotherapy drug (spartalizumab) to two existing targeted drugs (dabrafenib and trametinib) could better control advanced melanoma with a specific BRAF gene mutation. It involved 568 previously untreated patients whose cancer had spread and could not be surgically removed. The study was designed to compare the three-drug combination against the standard two-drug therapy to see if it was more effective and safe, but the trial was terminated early by the sponsor.

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Contacts and locations

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Locations

California Cancer Associates for Research and Excellence

Encinitas, California, 92024, United States
California Pacific Medical Center

San Francisco, California, 94115, United States
Johns Hopkins U

Lutherville, Maryland, 21093, United States
Kyoto University Hospital

Sakyo Ku, Kyoto, 606 8507, Japan
Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan
NYU Laura and Isaac Perlmutter Cancer Center

New York, New York, 10016, United States
National Cancer Hospital

Chuo Ku, Tokyo, 104 0045, Japan
Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
Novartis Investigative Site

CABA, Buenos Aires, C1125ABD, Argentina
Novartis Investigative Site

CABA, Buenos Aires, C1426ANZ, Argentina
Novartis Investigative Site

Rosario, Santa Fe Province, S2000KZE, Argentina
Novartis Investigative Site

Caba, C1431FWO, Argentina
Novartis Investigative Site

Gateshead, New South Wales, 2290, Australia
Novartis Investigative Site

North Sydney, New South Wales, 2060, Australia
Novartis Investigative Site

Greenslopes, Queensland, 4120, Australia
Novartis Investigative Site

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site

Nedlands, Western Australia, 6009, Australia
Novartis Investigative Site

Innsbruck, Tyrol, 6020, Austria
Novartis Investigative Site

Graz, 8036, Austria
Novartis Investigative Site

Linz, 4020, Austria
Novartis Investigative Site

Salzburg, A-5020, Austria
Novartis Investigative Site

Sankt Pölten, 3100, Austria
Novartis Investigative Site

Brussels, 1090, Belgium
Novartis Investigative Site

Brussels, 1200, Belgium
Novartis Investigative Site

Curitiba, Paraná, 80530 010, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 01246 000, Brazil
Novartis Investigative Site

Rio de Janeiro, 20560-120, Brazil
Novartis Investigative Site

Plovdiv, 4004, Bulgaria
Novartis Investigative Site

Sofia, 1303, Bulgaria
Novartis Investigative Site

Vancouver, British Columbia, V5Z 4E6, Canada
Novartis Investigative Site

Toronto, Ontario, M4N 3M5, Canada
Novartis Investigative Site

Montreal, Quebec, H3T 1E2, Canada
Novartis Investigative Site

Montreal, Quebec, H4A 3J1, Canada
Novartis Investigative Site

Sherbrooke, Quebec, J1H 5N4, Canada
Novartis Investigative Site

Temuco, Región de la Araucanía, 4810469, Chile
Novartis Investigative Site

Santiago, 7500921, Chile
Novartis Investigative Site

Santiago, 8420383, Chile
Novartis Investigative Site

Brno, Czech Republic, 656 53, Czechia
Novartis Investigative Site

Zlín, Czech Republic, 762 75, Czechia
Novartis Investigative Site

Hradec Králové, CZE, 500 05, Czechia
Novartis Investigative Site

Ostrava, Poruba, 708 52, Czechia
Novartis Investigative Site

Olomouc, 779 00, Czechia
Novartis Investigative Site

Prague, 100 34, Czechia
Novartis Investigative Site

Prague, 12808, Czechia
Novartis Investigative Site

Aarhus N, 8200, Denmark
Novartis Investigative Site

Limoges, Haute Vienne, 87000, France
Novartis Investigative Site

Amiens, 80054, France
Novartis Investigative Site

Besançon, 25030, France
Novartis Investigative Site

Bobigny, 93009, France
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Bordeaux, 33075, France
Novartis Investigative Site

Boulogne-Billancourt, 92104, France
Novartis Investigative Site

Caen, 14033, France
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Clermont-Ferrand, 63003, France
Novartis Investigative Site

Dijon, 21034, France
Novartis Investigative Site

Grenoble, 38043, France
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Le Mans, 72000, France
Novartis Investigative Site

Lille, 59037, France
Novartis Investigative Site

Lorient, 56322, France
Novartis Investigative Site

Lyon, 69373, France
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Marseille, 13885, France
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Mulhouse, 68070, France
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Nice, 06202, France
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Paris, 75475, France
Novartis Investigative Site

Pierre-Bénite, 69495, France
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Poitiers, 86021, France
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Reims, 51092, France
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Rouen, 76031, France
Novartis Investigative Site

Strasbourg, 67091, France
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Toulouse, 31059, France
Novartis Investigative Site

Vandœuvre-lès-Nancy, 54519, France
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Villejuif, 94800, France
Novartis Investigative Site

Mannheim, Baden-Wurttemberg, 68305, Germany
Novartis Investigative Site

Regensburg, Bavaria, 93053, Germany
Novartis Investigative Site

Leipzig, Saxony, 04103, Germany
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Halle, Saxony-Anhalt, 06120, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Berlin, 13578, Germany
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Bonn, 53105, Germany
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Chemnitz, 09117, Germany
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Dresden, 01307, Germany
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Düsseldorf, 40225, Germany
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Erfurt, 99089, Germany
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Essen, 45147, Germany
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Freiburg im Breisgau, 79106, Germany
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Gera, 07548, Germany
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Homburg, 66421, Germany
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Kiel, 24105, Germany
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Mainz, 55131, Germany
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Marburg, 35039, Germany
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Minden, 32429, Germany
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München, 81377, Germany
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Münster, 48157, Germany
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Stade, 21682, Germany
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Tübingen, 72076, Germany
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Athens, 115 27, Greece
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Athens, 18547, Greece
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Budapest, H 1122, Hungary
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Debrecen, 4032, Hungary
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Szeged, H 6725, Hungary
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Haifa, 3109601, Israel
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Jerusalem, 9112001, Israel
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Ramat Gan, 5265601, Israel
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Bari, BA, 70124, Italy
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Bergamo, BG, 24127, Italy
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Bologna, BO, 40138, Italy
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Brescia, BS, 25123, Italy
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Meldola, FC, 47014, Italy
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Genova, GE, 16132, Italy
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Monza, MB, 20900, Italy
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Milan, MI, 20133, Italy
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Milan, MI, 20141, Italy
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Modena, MO, 41124, Italy
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Padua, PD, 35100, Italy
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Roma, RM, 00167, Italy
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Siena, SI, 53100, Italy
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Candiolo, TO, 10060, Italy
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Torino, TO, 10126, Italy
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Verona, VR, 37134, Italy
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Naples, 80131, Italy
Novartis Investigative Site

León, Guanajuato, 37178, Mexico
Novartis Investigative Site

Guadalajara, Jalisco, 44100, Mexico
Novartis Investigative Site

Mexico City, Mexico City, 14080, Mexico
Novartis Investigative Site

Leiden, South Holland, 2333, Netherlands
Novartis Investigative Site

Amersfroort, 3818 ES, Netherlands
Novartis Investigative Site

Oslo, 0310, Norway
Novartis Investigative Site

Gdansk, 80 952, Poland
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Warsaw, 02 781, Poland
Novartis Investigative Site

Lisbon, 1099 023, Portugal
Novartis Investigative Site

Porto, 4200-072, Portugal
Novartis Investigative Site

Chelyabinsk, 454048, Russia
Novartis Investigative Site

Moscow, 115478, Russia
Novartis Investigative Site

Moscow, 143423, Russia
Novartis Investigative Site

Nizhny Novgorod, 603137, Russia
Novartis Investigative Site

Omsk, 644013, Russia
Novartis Investigative Site

Saint Petersburg, 197758, Russia
Novartis Investigative Site

Saint Petersburg, 198255, Russia
Novartis Investigative Site

Samara, 443011, Russia
Novartis Investigative Site

Málaga, Andalusia, 29010, Spain
Novartis Investigative Site

Seville, Andalusia, 41009, Spain
Novartis Investigative Site

Jerez de la Frontera, Cadiz, 11407, Spain
Novartis Investigative Site

Badalona, Catalonia, 08916, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08036, Spain
Novartis Investigative Site

A Coruña, Galicia, 15006, Spain
Novartis Investigative Site

Oviedo, Principality of Asturias, 33011, Spain
Novartis Investigative Site

Valencia, Valencia, 46014, Spain
Novartis Investigative Site

Las Palmas de Gran Canaria, 35016, Spain
Novartis Investigative Site

Madrid, 28009, Spain
Novartis Investigative Site

Madrid, 28034, Spain
Novartis Investigative Site

Madrid, 28050, Spain
Novartis Investigative Site

Madrid, 28222, Spain
Novartis Investigative Site

Gothenburg, SE-413 45, Sweden
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Lund, 221 85, Sweden
Novartis Investigative Site

Stockholm, SE 171 76, Sweden
Novartis Investigative Site

Aarau, Canton of Aargau, 5001, Switzerland
Novartis Investigative Site

Zurich, 8091, Switzerland
Novartis Investigative Site

Songkhla, Hat Yai, 90110, Thailand
Novartis Investigative Site

Bangkok, 10330, Thailand
Novartis Investigative Site

Truro, Cornwall, TR1 3LJ, United Kingdom
Novartis Investigative Site

Guildford, Surrey, GU2 7XX, United Kingdom
Novartis Investigative Site

Sutton, Surrey, SM2 5PT, United Kingdom
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Leicester, LE1 5WW, United Kingdom
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London, NW3 2QG, United Kingdom
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Manchester, M20 2BX, United Kingdom
Novartis Investigative Site

Middlesbrough, TS4 3BW, United Kingdom
Novartis Investigative Site

Preston, PR2 9HT, United Kingdom
Novartis Investigative Site

Rickmansworth Road, WD187HT, United Kingdom
Osaka International Cancer Institute

Osaka, Osaka, 541-8567, Japan
Stanford Cancer Center

Stanford, California, 94305, United States
Tokyo Metropolitan Komagome Hospital

Bunkyo Ku, Tokyo, 113-8677, Japan
UC Irvine Medical Center

Orange, California, 92613-4091, United States
Univ of TX MD Anderson Cancer Cntr

Houston, Texas, 77030, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Pittsburgh Med Center

Pittsburgh, Pennsylvania, 15213, United States
University of Tennessee Medical Ctr

Knoxville, Tennessee, 37920, United States
Utah Cancer Specialists

Salt Lake City, Utah, 84106, United States

Conditions

Explore the condition pages connected to this study.

MELANOMA