Novartis halts trial of experimental MDS drug

NCT ID NCT03946670

Terminated Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding an experimental drug called MBG453 to standard chemotherapy could better control a serious blood and bone marrow disorder called myelodysplastic syndrome (MDS). It involved 127 adults with intermediate to very high-risk MDS who were not candidates for stem cell transplant. The trial was terminated, and its main goals were to see if the combination led to more complete remissions and helped patients live longer without their disease getting worse.

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Contacts and locations

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Locations

City Of Hope National Med Center

Duarte, California, 91010, United States
City of Hope National Medical Center Medical Oncology & Therapeutic

Duarte, California, 91010, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Mary Crowley Cancer Research

Dallas, Texas, 75251, United States
Novartis Investigative Site

Vienna, 1140, Austria
Novartis Investigative Site

Brasschaat, 2930, Belgium
Novartis Investigative Site

Leuven, 3000, Belgium
Novartis Investigative Site

Toronto, Ontario, M5G 2M9, Canada
Novartis Investigative Site

Québec, Quebec, G1J 1Z4, Canada
Novartis Investigative Site

Brno, 625 00, Czechia
Novartis Investigative Site

Prague, 128 08, Czechia
Novartis Investigative Site

Toulouse, 31059, France
Novartis Investigative Site

Leipzig, Saxony, 04103, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Alexandroupoli, 681 00, Greece
Novartis Investigative Site

Larissa, 411 10, Greece
Novartis Investigative Site

Pátrai, 265 04, Greece
Novartis Investigative Site

Hong Kong, Hong Kong
Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site

Nyíregyháza, 4400, Hungary
Novartis Investigative Site

Florence, FI, 50134, Italy
Novartis Investigative Site

Milan, MI, 20162, Italy
Novartis Investigative Site

Rozzano, MI, 20089, Italy
Novartis Investigative Site

Reggio Calabria, RC, 89124, Italy
Novartis Investigative Site

Roma, RM, 00133, Italy
Novartis Investigative Site

Fukuoka, Fukuoka, 812-8582, Japan
Novartis Investigative Site

Fukushima, Fukushima, 960 1295, Japan
Novartis Investigative Site

Isehara, Kanagawa, 259-1193, Japan
Novartis Investigative Site

Kumamoto, Kumamoto, 860-0008, Japan
Novartis Investigative Site

Sendai, Miyagi, 983 8520, Japan
Novartis Investigative Site

Nagasaki, Nagasaki, 852-8501, Japan
Novartis Investigative Site

Bunkyo Ku, Tokyo, 113-8677, Japan
Novartis Investigative Site

Gifu, 500 8513, Japan
Novartis Investigative Site

Osaka, 545-8586, Japan
Novartis Investigative Site

Seoul, Korea, 03080, South Korea
Novartis Investigative Site

Seoul, 06351, South Korea
Novartis Investigative Site

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site

Santander, Cantabria, 39008, Spain
Novartis Investigative Site

Málaga, 29010, Spain
Novartis Investigative Site

Kaohsiung City, 83301, Taiwan
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Samsun, Atakum, 55200, Turkey (Türkiye)
Novartis Investigative Site

Köseköy, Kocaeli, 41380, Turkey (Türkiye)
Novartis Investigative Site

Izmir, 35100, Turkey (Türkiye)
Novartis Investigative Site

Manchester, M20 2BX, United Kingdom
Ohio State Comprehensive Cancer Center James Cancer Hospital

Columbus, Ohio, 73210, United States
The Cancer Institute of New Jersey

New Brunswick, New Jersey, 08901, United States
Yale University School Of Medicine

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

MYELODYSPLASTIC SYNDROMES