New hope for hard-to-treat cancers: experimental drug MBRC-101 enters human trials
NCT ID NCT06014658
First seen Mar 06, 2026 · Last updated May 15, 2026 · Updated 15 times
Summary
This study tests an experimental drug called MBRC-101 in people with advanced solid tumors that no longer respond to standard therapies. The drug works like a guided missile, delivering a chemotherapy agent directly to cancer cells that carry a specific marker (EphA5). The trial has three parts: first, finding the safest and most effective dose; second, checking safety and early signs of tumor shrinkage; and third, measuring how well the drug works at the chosen dose. About 130 adults with various advanced cancers will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Carolina BioOncology Institute
ACTIVE_NOT_RECRUITINGHuntersville, North Carolina, 28078, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Comprehensive Cancer Center of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Horizon Oncology Research
COMPLETEDLafayette, Indiana, 47905, United States
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Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
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Medical University of South Carolina (MUSC)
RECRUITINGCharleston, South Carolina, 29425, United States
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NEXT Oncology
RECRUITINGAustin, Texas, 78758, United States
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NEXT Oncology
RECRUITINGIrving, Texas, 75039, United States
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NEXT Oncology
RECRUITINGFairfax, Virginia, 22031, United States
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PRISMA Health, Institute for Translational Oncology
RECRUITINGGreenville, South Carolina, 29605, United States
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08903, United States
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Contact
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UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
Contact
Contact Email: •••••@•••••
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Colorado, Anschutz Cancer Pavilion (ACP(
RECRUITINGAurora, Colorado, 80045, United States
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University of Pennsylvania, Abramson Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19014, United States
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Winship Cancer Institute, Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact
Conditions
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