New CAR T-Cell therapy aims to tackle tough lymphoma

NCT ID NCT04844866

Recruiting now Disease control Sponsor: Miltenyi Biomedicine GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests a new treatment called MB-CART2019.1 for people with a type of aggressive lymphoma (DLBCL) that has come back or not responded to treatment. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The study compares this new therapy to standard treatments in 213 participants who cannot receive high-dose chemotherapy with a stem cell transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MB-CART2019.1 (a CAR T-cell therapy made from the patient's own immune cells, designed to target and kill lymphoma cells)
What this could lead to: If successful, this could offer a new treatment option for people with hard-to-treat lymphoma who have few alternatives.
What could go wrong: This is a phase 2 trial, so it is still early. The therapy may not work better than standard care, and CAR T-cell therapies can cause serious side effects like cytokine release syndrome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma hematopoietic and lymphoid system neoplasm non-Hodgkin lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

Locations

American Hospital
NOT_YET_RECRUITING

Şişli, 34365, Turkey (Türkiye)
Amsterdam Universitaire Medische Centra (UMC) - locatie Amsterdam Medisch Centrum (AMC)
RECRUITING

Amsterdam, 1105 AZ, Netherlands
Azienda Ospedaliera San Giovanni Battista Di Torino
RECRUITING

Torino, 10126, Italy
CHRU de Lille - Hopital Claude Huriez
ACTIVE_NOT_RECRUITING

Lille, 59000, France
CHU de Nancy Hopitaux de Brabois
RECRUITING

Vandœuvre-lès-Nancy, 54500, France
Catalan Institute of Oncology (ICO) Hospitalet
RECRUITING

Barcelona, 08907, Spain
Centre Hospitalier Lyon Sud, Hospices Civils de Lyon Groupement Hospitalier Sud
ACTIVE_NOT_RECRUITING

Lyon, 69495, France
Centre Hospitalier Universitaire (CHU) - Hopital Henri Mondor
RECRUITING

Créteil, 94010, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Haut-Leveque
RECRUITING

Pessac, 33600, France
Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hopital Hotel Dieu
ACTIVE_NOT_RECRUITING

Nantes, 44093, France
Centre Hospitalier Universitaire de Poitiers
RECRUITING

Poitiers, 86000, France
Centre Paoli Calmettes
ACTIVE_NOT_RECRUITING

Marseille, 13273, France
Clinica Universidad de Navarra
RECRUITING

Pamplona, 31008, Spain
Debreceni Egyetem - Orvos es Egeszsegtudomanyi Centrum (DEOEC) (University of Debrecen Medical and Health Science Center)
RECRUITING

Debrecen, 4032, Hungary
Del-Pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
RECRUITING

Budapest, 1097, Hungary
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
NOT_YET_RECRUITING

Ankara, 06200, Turkey (Türkiye)
Erasmus University Medical Center
ACTIVE_NOT_RECRUITING

Rotterdam, 3015 GC, Netherlands
FNsP Ostrava
RECRUITING

Ostrava, 70852, Czechia
Helsinki University Comprehensive Cancer Center
NOT_YET_RECRUITING

Helsinki, 00029, Finland
Hospital Clinic de Barcelona (Hospital Clinic i Provincial)
RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Clínico San Carlos (HCSC)
RECRUITING

Madrid, 28040, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen De La Arrixaca (Huva)
RECRUITING

Murcia, 30120, Spain
Institut Universitaire du Cancer Service d´hématologie
RECRUITING

Toulouse, 31059, France
Instituto Portugues de Oncologia do Porto Francisco Gentil E.P.E
NOT_YET_RECRUITING

Porto, 4200-072, Portugal
Jules Bordet lnstitute
RECRUITING

Anderlecht, 1070, Belgium
Klinikum Erlangen der Friedrich-Alexander-Universitaet Erlangen-Nuernberg
RECRUITING

Erlangen, 91054, Germany
Klinikum der Universitat München, Studienzentrale fur Hematologie der Medizinischen Klinik II
RECRUITING

München, 81377, Germany
Koc Universitesi Hastanesi (Koc University Hospital)
NOT_YET_RECRUITING

Zeytinburnu, 34010, Turkey (Türkiye)
LKH - Medizinische Universitaet Graz
ACTIVE_NOT_RECRUITING

Graz, 8036, Austria
Leiden University Medical Center (LUMC)
RECRUITING

Leiden, 2333 ZA, Netherlands
Medizinische Universitaet Wien - Allgemeines Krankenhaus der Stadt Wien (AKH)
RECRUITING

Vienna, 1090, Austria
Ordensklinikum Linz GmbH Elisabethinen
RECRUITING

Linz, 4020, Austria
Oulu University Central Hospital
RECRUITING

Oulu, 90220, Finland
Turku University Hospital
RECRUITING

Turku, 20520, Finland
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitaetsklinikum Knappschaftskrankenhaus Bochum der Ruhr-Universitat Bochum
RECRUITING

Bochum, 44892, Germany
Universitaetsklinikum Koeln
RECRUITING

Cologne, 50937, Germany
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitatsklinikum Augsburg
RECRUITING

Augsburg, 86156, Germany
Universitatsklinikum Innsbruck Universitatsklinik fur Innere Medizin V
RECRUITING

Innsbruck, 6020, Austria
University Hospital Center Zagreb
RECRUITING

Zagreb, 10000, Croatia
University Hospital Hradec Kralove
RECRUITING

Hradec Králové, 50005, Czechia
University Hospital Regensburg
RECRUITING

Regensburg, 93053, Germany
University Hospital of Tuebingen
RECRUITING

Tübingen, 72076, Germany
University Medical Center Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
University Medical Center Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Uniwersytecki Szpital Kliniczny - Klinika Hematologii, Terapii Komorkowych i Chorob Wewnetrznych
ACTIVE_NOT_RECRUITING

Wroclaw, 50367, Poland

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