Engineered immune cells take on tough blood cancers in early trial
NCT ID NCT03853616
First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This early-phase trial is testing a new treatment called MB-CART19.1 for people with certain blood cancers (like leukemia and lymphoma) that have come back or not responded to other treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goals are to find a safe dose and see if it's feasible to give this treatment to about 48 adults and children.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MB-CART19.1 (a type of CAR T cell therapy made from the patient's own immune cells)
- What this could lead to
- If successful, this could lead to a new treatment option for patients with hard-to-treat B cell cancers that have not responded to standard therapies.
- What could go wrong
- This is a very early (Phase 1) trial with only 48 participants, so safety and dosing are still being figured out. CAR T cell therapy can cause serious side effects like cytokine release syndrome.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Charité - University clinic, pediatric clinic with focus on oncology and hematology
Berlin, 13353, Germany
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Children's Hospital of Dr. von Hauner by Ludwig-Maximilian University
Munich, 80337, Germany
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Tuebingen University clinic, medical university clinic for internal medicine
Tübingen, 72076, Germany
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University clinic for children and youth medicine
Tübingen, 72076, Germany
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University clinic, pediatric hematology and oncology
Würzburg, 97070, Germany
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University medicine Goettingen, Clinic of hematology and medical oncology
Göttingen, 37075, Germany
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Universitätsklinikum Erlangen
Erlangen, 91054, Germany
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Universitätsklinikum Münster - Klink für Kinderheilkunde und Jugendmedizin / Pädiatrische Hämatologie und Onkologie
Münster, 48149, Germany
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Universitätsklinikum Münster - Medizinische Klinik A / KMT Zentrum
Münster, 48149, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A shot at safer CAR t: early brain protection for lymphoma patients?
- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?
- A simple blood test may reveal hidden infertility risk in young cancer survivors
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?
- What happens years after CAR-T therapy? a study aims to find out