New shot could help hemophilia patients switch treatments

NCT ID NCT06703606

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests a new medicine called marstacimab in people with severe hemophilia A who want to switch from their current preventive treatment, emicizumab. The study includes 15 adolescents and adults who will receive weekly injections of marstacimab for 4 months. Researchers will monitor safety and how the body processes the drug to guide future use in clinical practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: marstacimab
What this could lead to: If successful, this could offer a new preventive treatment option for people with severe hemophilia A who want to switch from their current medication.
What could go wrong: This is a very early Phase 1 study with only 15 participants, so safety and effectiveness are not yet proven. It may not work for everyone or could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SEVERE HEMOPHILIA A are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hemophilia A severe hemophilia A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE HEMOPHILIA A

Contacts and locations

Locations

Brody School of Medicine at East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
ECU Health Medical Center
RECRUITING

Greenville, North Carolina, 27834, United States
Ege University Faculty of Medicine Dean's Office
RECRUITING

Bornova, İzmir, 35100, Turkey (Türkiye)
Istanbul Universitesi Tıp Fakultesi Onkoloji Enstitusu
RECRUITING

Fatih, İ̇stanbul, 34093, Turkey (Türkiye)
K J Somaiya Hospital & Research Centre
RECRUITING

Mumbai, Maharashtra, 400022, India
Nirmal Hospital Pvt Ltd.
RECRUITING

Surat, Gujarat, 395002, India
Orthopaedic Institute for Children/Orthopaedic Hemophilia Treatment Center
RECRUITING

Los Angeles, California, 90007, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.