Experimental liposomal chemo shows promise in kids with relapsed leukemia
NCT ID NCT02879643
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested a liposomal form of the chemotherapy drug vincristine (Marqibo) combined with standard UK ALL R3 chemotherapy in 29 children, adolescents, and young adults with relapsed acute lymphoblastic leukemia. The main goal was to see if it was safe and tolerable at different doses. The study also looked at how often serious side effects or treatment delays occurred.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vincristine sulfate liposome injection (Marqibo)
What this could lead to
If successful, this could offer a new chemotherapy option for children and young adults with relapsed acute lymphoblastic leukemia.
What could go wrong
This is a small, early-phase safety study with only 29 participants. It may not lead to better outcomes, and there are risks of serious side effects like nerve damage or infections.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LYMPHOBLASTIC LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
All Children's Hospital
St. Petersburg, Florida, 33701, United States
-
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
-
CS Mott Children's Hospital, Ann Arbor
Ann Arbor, Michigan, 48109, United States
-
Children's Healthcare of Atlanta at Egleston
Atlanta, Georgia, 30322, United States
-
Children's Hospital New York-Presbyterian
New York, New York, 10032, United States
-
Children's Hospital Orange County
Orange, California, 92868, United States
-
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
-
Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, 55404, United States
-
Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
-
Childrens Hospital Los Angeles
Los Angeles, California, 90027, United States
-
Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
-
Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
-
Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
-
Lady Cilento Children's Hospital
South Brisbane, Queensland, 4101, Australia
-
Levine Children's Hospital
Charlotte, North Carolina, 28203, United States
-
Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
-
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
-
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, 37232, United States
-
National Cancer Institute, Pediatric Oncology Branch
Bethesda, Maryland, 20892, United States
-
Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
-
Oregon Health & Science University
Portland, Oregon, 97239, United States
-
Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
-
Rainbow Babies & Children's Hospital
Cleveland, Ohio, 44106, United States
-
Royal Children's Hospital, Melbourne
Parkville, Victoria, 3052, Australia
-
Sainte-Justine University Hospital Center
Montréal, Québec, H3T-1C5, Canada
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
-
Sidney Kimmel Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231, United States
-
Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
-
Texas Children's Cancer Center, Baylor
Houston, Texas, 77030, United States
-
The Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
-
The Children's Hospital, University of Colorado
Aurora, Colorado, 80045, United States
-
UCSF School of Medicine
San Francisco, California, 94158, United States
-
University of Miami
Miami, Florida, 33136, United States
-
University of Texas Southwestern Medical Center
Dallas, Texas, 75235, United States