New combo aims for deep remission in lymphoma patients

NCT ID NCT05951959

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 24 times

Summary

This study tests a combination of three drugs (acalabrutinib, venetoclax, and rituximab) in people with untreated mantle cell lymphoma. The goal is to see if the treatment can make the cancer undetectable in the blood and keep it under control. Participants who respond well may stop some medications and be monitored, with the option to restart treatment if needed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Hackensack, New Jersey, 07601, United States

  • Research Site

    Stony Brook, New York, 11794, United States

  • Research Site

    Cleveland, Ohio, 44195, United States

  • Research Site

    Philadelphia, Pennsylvania, 19104, United States

  • Research Site

    Houston, Texas, 77030, United States

  • Research Site

    Heidelberg, 3084, Australia

  • Research Site

    Kogarah, NSW 2217, Australia

  • Research Site

    Nedlands, 6009, Australia

  • Research Site

    Sydney, 2109, Australia

  • Research Site

    Porto Alegre, 90035-003, Brazil

  • Research Site

    Rio de Janeiro, 22061-080, Brazil

  • Research Site

    São Paulo, 01401-002, Brazil

  • Research Site

    São Paulo, 05403-010, Brazil

  • Research Site

    Edmonton, Alberta, T6G 1Z2, Canada

  • Research Site

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Research Site

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Research Site

    Barrie, Ontario, L4M 6M2, Canada

  • Research Site

    Toronto, Ontario, M5G 2M9, Canada

  • Research Site

    Montreal, Quebec, H3T 1E2, Canada

  • Research Site

    Gdynia, 81-519, Poland

  • Research Site

    Krakow, 30-727, Poland

  • Research Site

    Warsaw, 02-781, Poland

  • Research Site

    Madrid, 28041, Spain

  • Research Site

    Birmingham, B9 5SS, United Kingdom

  • Research Site

    Gloucester, GL1 3NN, United Kingdom

  • Research Site

    London, SW3 6JJ, United Kingdom

  • Research Site

    Norwich, NR4 7UY, United Kingdom

  • Research Site

    Nottingham, NG5 1PB, United Kingdom

  • Research Site

    Plymouth, PL68BQ, United Kingdom

Conditions

Explore the condition pages connected to this study.