Could a simple sugar solution replace your colonoscopy prep?
NCT ID NCT07465705
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether mannitol, a sugar alcohol, works as well as the standard Plenvu for cleaning the bowel before a colonoscopy. About 412 adults scheduled for colonoscopy will be randomly assigned to take either mannitol or Plenvu. The goal is to see if mannitol provides adequate bowel cleansing, making it a potentially simpler or cheaper alternative.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mannitol
What this could lead to
If mannitol works as well as Plenvu, it could offer a cheaper or more tolerable option for colonoscopy preparation.
What could go wrong
This is a non-inferiority trial, so mannitol may not be better—just not worse. Results may not apply to all patients or settings.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Algemeen Ziekenhuis Damiaan Oostende
RECRUITINGOstend, 8400, Belgium
Contact
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Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
RECRUITINGBologna, 40138, Italy
Contact
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Azienda Provinciale Per I Servizi Sanitari
RECRUITINGTrento, 38122, Italy
Contact
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Azienda Unita Sanitaria Locale Di Modena - Ospedale Ramazzini di Carpi
RECRUITINGCarpi, Modena, 41012, Italy
Contact
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Centro Di Riferimento Oncologico Di Aviano
RECRUITINGAviano, Pordenone, 33081, Italy
Contact
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Congregazione Delle Suore Infermiere Dell'Addolorata - Ospedale Valduce
RECRUITINGComo, 22100, Italy
Contact
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Fondazione IRCCS Cà Granda Ospedale Policlinico
RECRUITINGMilan, 20122, Italy
Contact
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Fondazione Poliambulanza
RECRUITINGBrescia, 25124, Italy
Contact
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H-T.Centrum Medyczne Sp. z o.o. sp.k.
RECRUITINGTychy, 43-100, Poland
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Hopital Erasme
RECRUITINGAnderlecht, 1070, Belgium
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Hospital Clinic De Barcelona
RECRUITINGBarcelona, 08036, Spain
Contact
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IRCCS Ospedale Sacro Cuore Don Calabria
RECRUITINGNegrar, Verona, 37024, Italy
Contact
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Istituto Europeo di Oncologia
RECRUITINGMilan, 20141, Italy
Contact
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Katholieke Universiteit te Leuven
RECRUITINGLeuven, 3000, Belgium
Contact
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Klinika Reuma Park Sp. z o.o. S.K.
ACTIVE_NOT_RECRUITINGWarsaw, 02-665, Poland
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Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
RECRUITINGWarsaw, 02-781, Poland
Contact
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Policlinico Universitario A. Gemelli
RECRUITINGRoma, 00168, Italy
Contact
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Region Oerebro Laen
RECRUITINGÖrebro, 701 85, Sweden
Contact