Could a sugar alcohol replace the standard colonoscopy prep?
NCT ID NCT04759885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests mannitol, a sugar alcohol, as a bowel preparation for colonoscopy in 886 adults. It first finds the best dose, then compares it to the standard split-dose PEG solution. The goal is to see if mannitol cleans the bowel just as well and is safe.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mannitol
What this could lead to
If it works, mannitol could offer a simpler, single-dose bowel preparation option for colonoscopy.
What could go wrong
This is an early-phase dose-finding study, so the best dose is still uncertain. Mannitol may not be as effective as the standard split-dose PEG solution.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
Contacts and locations
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Locations
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ASSL Carbonia - Presidio Ospedaliero CTO di Iglesias
Iglesias, CI, Italy
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ASST Grande Ospedale Metropolitano Niguarda
Milan, MI, 20162, Italy
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ASST Rhodense - Presidi di Rho e Garbagnate
Garbagnate Milanese, MI, 20024, Italy
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ASST Sette Laghi - Ospedale di Circolo e Fondazione Macchi
Varese, 21100, Italy
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Azienda Ospedaliero Universitaria Pisana- Ospedale Cisanello
Pisa, PI, 56124, Italy
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Azienda Ospedaliero-Universitaria Maggiore della Carità
Novara, 28100, Italy
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Azienda USL di Modena - Ospedale Ramazzini di Carpi
Carpi, MO, 41012, Italy
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Centre Hospitalier Henri Duffaut
Avignon, France
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Centre Hospitalier Universitaire de Montpellier
Montpellier, France
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Centro di Riferimento Oncologico IRCCS
Aviano, PN, 33081, Italy
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Clinical Hospital of Russian Railways N.A. Semashko
Moscow, Russia
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Fondazione Casa Sollievo Della Sofferenza
San Giovanni Rotondo, FG, 71013, Italy
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Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano
Milan, MI, 20122, Italy
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Fondazione Poliambulanza - Istituto Ospedaliero
Brescia, BR, 25124, Italy
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Hospices civils de Lyon
Lyon, France
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Hôpital Edouard Herriot
Lyon, France
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IRCCS "Saverio De Bellis"
Castellana Grotte, BA, 70013, Italy
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IRCCS Ospedale San Raffaele
Milan, MI, Italy
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IRCCS Policlinico San Donato
San Donato Milanese, MI, 20097, Italy
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Irkutsk State Medical Academy of Postgraduate Education
Irkutsk, Russia
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Istituto Europeo di Oncologia
Milan, MI, Italy
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Katholisches Klinikum Mainz
Mainz, Germany
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Klinikum Worms Medizinische Klinik II
Worms, Germany
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Klinikum der Stadt Ludwigshafen
Ludwigshafen, Germany
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Medical Center of Diagnostics and Prevention
Yaroslavl, Russia
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Moscow Clinical Research and Practical Center of the Department of Health
Moscow, Russia
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Ospedale Sacro Cuore
Negrar, VR, 37024, Italy
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Ospedale Valduce
Como, CO, Italy
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Policlinico Universitario A. Gemelli
Roma, RO, 00168, Italy
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Praxis für Gastroenterologie und Fachärztliche Innere Medizin, Im Haus der Gesundheit
Ludwigshafen am Rhein, Germany
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Presidio Ospedaliero Santa Chiara
Trento, TN, 38100, Italy
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Private educational organization of higher education "Medical University "Reaviz"
Samara, Russia
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Railway Clinical Hospital
Rostov-on-Don, Russia
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Regional Oncological Clinical Hospital
Yaroslavl, Russia
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State Central Clinical Hospital A. N. Ryzhykh
Moscow, Russia