Could a Two-Drug combo during pregnancy prevent more malaria and save more babies?

This study tested whether giving pregnant women a combination of two malaria drugs (sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine) every 4 weeks works better than either drug alone to prevent malaria and reduce serious birth problems like low birth weight, preterm birth, or stillbirth. Over 2,700 HIV-negative pregnant women in Uganda took part. The goal was to find the safest and most effective way to protect both mother and baby from malaria.