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Magnesium vs lidocaine: which drug tames the Body's stress response to a breathing tube?

NCT ID NCT07793955

Disease control Sponsor: Lady Reading Hospital, Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 09, 2026 · Updated 3 times

Summary

This trial tests whether magnesium sulfate or lidocaine better controls the sudden rise in heart rate and blood pressure that can happen when a breathing tube is placed during general anesthesia. Adults aged 18 to 70 having surgery under general anesthesia will receive one of the two drugs before intubation. Researchers will measure heart rate and blood pressure at set times to compare how well each drug steadies these vital signs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intravenous magnesium sulfate
What this could lead to
If magnesium sulfate works better than lidocaine, it could offer a safer, more effective way to prevent dangerous blood pressure and heart rate spikes during anesthesia.
What could go wrong
This is a small, early-stage trial, so results may not apply to all patients. Both drugs can cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 78 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 18-70 yrs * male and female patients * patients undergoing elective or emergency procedures under general anesthesia Exclusion Criteria: * pregnancy * anticipated difficult airway

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodynamic response to laryngoscopy and orotracheal intubation Hemodynamic response to laryngoscopy and tracheal intubation

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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