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Could a single magnesium dose tame Surgery's blood pressure swings?

NCT ID NCT07079514

Symptom relief Sponsor: Ziauddin University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether giving magnesium sulphate before laparoscopic gallbladder surgery can prevent the sharp rises in blood pressure and heart rate caused by inflating the abdomen with gas. Researchers will compare 30 patients who receive magnesium with 30 who receive a placebo, measuring vital signs during surgery and tracking pain, opioid use, and nausea afterward. The goal is to see if this simple drug can make the procedure safer and recovery more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnesium sulphate given as an intravenous dose before surgery
What this could lead to
If it works, magnesium sulphate could become a standard add-on during laparoscopic surgery to keep blood pressure steady and reduce pain, opioid use, and nausea afterward.
What could go wrong
This is an early, small trial with only 60 participants, so results may not apply broadly. Magnesium can cause low blood pressure or heart rhythm issues, and people with certain conditions are excluded.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

60 people

The number who actually took part.

Started

Jan 2025

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 85 * Gender: Male /Female * ASA status I/II/III * Patients undergoing elective Laparoscopic cholecystectomy Exclusion Criteria: * Known Hypermagnesemia * Known allergy to Magnesium * Any degree of Heart Block * Patients on Calcium Channel Blockers * Known CKD/AKI

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Conditions

The condition(s) this trial relates to.

Pain Pneumoperitoneum Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodynamics instability Pain after surgery Ponv in laparoscopic cholocystectomies

Contacts and locations

Locations

  • Dr Ziauddin Hospital

    Karachi, Sindh, 75600, Pakistan

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