Could a magnesium supplement boost sleep and brainpower under fatigue?
NCT ID NCT07706283
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This study tests whether taking magnesium L-threonate for six weeks improves sleep quality, mental focus during fatigue, and muscle function in healthy adults aged 18 to 45. Participants receive either the supplement or a placebo, and researchers measure sleep scores, reaction times, and jump height. The trial also looks at whether effects differ by sex or weight.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- magnesium L-threonate (a dietary supplement)
- What this could lead to
- If it works, this could point toward a simple supplement to help healthy adults sleep better and think more clearly when mentally tired.
- What could go wrong
- This is a small, early-stage trial in healthy people, so results may not apply to everyone. The supplement may show no benefit over a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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81 people
The number who actually took part.
- Started
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Dec 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy male or female adults aged 18-45 years * Free from diagnosed neurological, cardiovascular, metabolic, or psychiatric conditions * Not currently taking medications or supplements known to influence cognitive or neuromuscular function * Willing to maintain habitual diet, physical activity, and sleep routines throughout the study period Exclusion Criteria: * Pregnant or breastfeeding * Diagnosed sleep disorder * Initiated any new supplement or medication regimen within the past three months * Failed to meet ≥85% supplementation adherence threshold during the study (post-enrollment exclusion) * Technical data malfunction resulting in unrecoverable testing data (post-enrollment exclusion) * Identified as a multivariate outlier (values exceeding ±3 SD from the group mean on primary outcomes; post-enrollment exclusion)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Barry University
Miami Shores, Florida, 33161, United States