Can a magnesium implant rebuild bone and cut pain after tumor surgery?

NCT ID NCT07794202

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether a magnesium-containing bone repair material can ease pain and help bone regrow after surgery to remove bone tumors in the arms or legs. About 72 adults aged 18 to 75 will receive either the magnesium material or a standard non-magnesium material to fill the gap left by the tumor. Researchers will measure painkiller use, new bone growth, infection rates, and tumor recurrence over 12 weeks, with follow-ups at 1, 3, and 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnesium-containing degradable polymer bone repair material, implanted during surgery to fill bone defects after tumor removal
What this could lead to
If it works, this material could reduce pain and improve bone healing after tumor removal, offering a better option for patients with bone defects.
What could go wrong
This is an early, small trial, so results may not apply broadly. The material could fail to match standard care or cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects with bone tumors (benign or borderline) or tumor-like bone lesions of extremities confirmed by imaging and/or pathology, scheduled for surgical resection. * Bone defects formed after resection of extremity bone tumor, requiring artificial bone repair material for defect filling and reconstruction. * Age from 18 to 75 years old, regardless of gender. * Good general preoperative condition and able to tolerate surgical treatment. * Voluntarily participate in this study, provide written informed consent, and be judged by investigators to comply with study protocol and complete follow-up visits. * No postoperative local rejection or allergic reaction at the operative site. * Diameter of bone defect ≤ 6 cm, and product usage volume ≤ 77 cm³. * Bone defect located in upper extremity (humerus, ulna-radius, carpal bones) or lower extremity (femur, tibia, fibula, ankle, foot bones). Exclusion Criteria: * Active local infection at operative site or severe systemic infection. * Severe bone metabolic diseases that may interfere with bone healing, such as severe osteoporosis or uncontrolled hyperparathyroidism. * Severe cardiac, hepatic, renal insufficiency or other serious systemic diseases which cannot tolerate surgery or interfere with study evaluation. * Severe hematological or immune system disorders. * Pregnant or lactating women. * Expected survival less than 12 months, or unable to complete at least 12-month follow-up. * Known or suspected allergy to collagen, hydroxyapatite or other components of bone repair materials. * Occurrence of local rejection or allergic reaction at operative site after surgery. * Diameter of bone defect \> 6 cm, or product usage volume \> 77 cm³. * Any other conditions judged by investigators making the subject unsuitable for enrollment.

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As listed by the trial registrant

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How to take part

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Contacts and locations

Locations

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

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