Can a magnesium implant rebuild bone and cut pain after tumor surgery?
NCT ID NCT07794202
First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time
Summary
This trial tests whether a magnesium-containing bone repair material can ease pain and help bone regrow after surgery to remove bone tumors in the arms or legs. About 72 adults aged 18 to 75 will receive either the magnesium material or a standard non-magnesium material to fill the gap left by the tumor. Researchers will measure painkiller use, new bone growth, infection rates, and tumor recurrence over 12 weeks, with follow-ups at 1, 3, and 6 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Magnesium-containing degradable polymer bone repair material, implanted during surgery to fill bone defects after tumor removal
- What this could lead to
- If it works, this material could reduce pain and improve bone healing after tumor removal, offering a better option for patients with bone defects.
- What could go wrong
- This is an early, small trial, so results may not apply broadly. The material could fail to match standard care or cause unexpected side effects.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects with bone tumors (benign or borderline) or tumor-like bone lesions of extremities confirmed by imaging and/or pathology, scheduled for surgical resection. * Bone defects formed after resection of extremity bone tumor, requiring artificial bone repair material for defect filling and reconstruction. * Age from 18 to 75 years old, regardless of gender. * Good general preoperative condition and able to tolerate surgical treatment. * Voluntarily participate in this study, provide written informed consent, and be judged by investigators to comply with study protocol and complete follow-up visits. * No postoperative local rejection or allergic reaction at the operative site. * Diameter of bone defect ≤ 6 cm, and product usage volume ≤ 77 cm³. * Bone defect located in upper extremity (humerus, ulna-radius, carpal bones) or lower extremity (femur, tibia, fibula, ankle, foot bones). Exclusion Criteria: * Active local infection at operative site or severe systemic infection. * Severe bone metabolic diseases that may interfere with bone healing, such as severe osteoporosis or uncontrolled hyperparathyroidism. * Severe cardiac, hepatic, renal insufficiency or other serious systemic diseases which cannot tolerate surgery or interfere with study evaluation. * Severe hematological or immune system disorders. * Pregnant or lactating women. * Expected survival less than 12 months, or unable to complete at least 12-month follow-up. * Known or suspected allergy to collagen, hydroxyapatite or other components of bone repair materials. * Occurrence of local rejection or allergic reaction at operative site after surgery. * Diameter of bone defect \> 6 cm, or product usage volume \> 77 cm³. * Any other conditions judged by investigators making the subject unsuitable for enrollment.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510080, China
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