Gene therapy shot could end monthly eye injections for wet AMD
NCT ID NCT07317934
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests a single injection of LX102 gene therapy under the retina for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. About 332 participants will receive either LX102 or standard aflibercept injections. The goal is to see if LX102 can maintain or improve vision while reducing the need for repeated treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LX102 (a gene therapy given as a single injection under the retina)
What this could lead to
If successful, this could offer a one-time treatment for wet AMD, potentially reducing the need for frequent eye injections.
What could go wrong
This is an early Phase 3 trial, so results are not yet proven. Gene therapy carries risks like inflammation or retinal damage, and it may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aier Eye Hospital Group Co., LTD. Changsha Aier Eye Hospital
NOT_YET_RECRUITINGChangsha, Hunan, 410015, China
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Beijing Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100730, China
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Central Theater Command General Hospital of PLA
NOT_YET_RECRUITINGWuhan, Hubei, 430060, China
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Eye & ENT Hospital of Fudan University
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200031, China
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Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong
NOT_YET_RECRUITINGShantou, Guangdong, 515041, China
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Peking Union Medical College Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100730, China
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Qilu Hospital of Shandong University
NOT_YET_RECRUITINGJinan, Shandong, 250012, China
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Qingdao Eye Hospital Affiliated to Shandong First Medical University
NOT_YET_RECRUITINGQingdao, Shandong, 266071, China
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Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 201801, China
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Shandong Eye Hospital
NOT_YET_RECRUITINGJinan, Shandong, 250021, China
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Shanghai General Hospital
RECRUITINGShanghai, Shanghai Municipality, 200080, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanxi Bethune Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, 030032, China
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Shanxi Eye Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, 030002, China
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Sichuan Provincial People's Hospital
NOT_YET_RECRUITINGChengdu, Sichuan, 646100, China
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The Affiliated Eye Hospital of Nanjing Medical University
NOT_YET_RECRUITINGNanjing, Jiangsu, 210029, China
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The Eye Hospital of Wenzhou Medical University
NOT_YET_RECRUITINGWenzhou, Zhejiang, 325027, China
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The First Affiliated Hospital of Air Force Medical University
NOT_YET_RECRUITINGXi’an, Shanxi, 710032, China
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The First Affiliated Hospital of Jinan University
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510632, China
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The First Affiliated Hospital of University of Science and Technology of China
NOT_YET_RECRUITINGHefei, Anhui, 230601, China
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The Second Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, 400010, China
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The Second Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150001, China
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The Second Hospital of Jilin University
NOT_YET_RECRUITINGChangchun, Jilin, 130022, China
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The Second Xiangya Hospital, Central South University
NOT_YET_RECRUITINGChangsha, Hunan, 410011, China
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Tianjin Eye Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300020, China
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Tianjin Medical University Eye Hospital
RECRUITINGTianjin, Tianjin Municipality, 300384, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West China Hospital, Sichuan University
NOT_YET_RECRUITINGChengdu, Sichuan, 610041, China
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Xi 'an People's Hospital (Xi 'an No.4 Hospital)
NOT_YET_RECRUITINGXi’an, Shanxi, 710004, China
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Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200092, China
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Xuzhou First People's Hospital
NOT_YET_RECRUITINGXuzhou, Jiangsu, 221002, China
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Zhejiang Provincial People's Hospital
NOT_YET_RECRUITINGHangzhou, Zhejiang, 310014, China
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Zhongshan Ophthalmic Center, Sun Yat-sen University
NOT_YET_RECRUITINGZhongshan, Guangdong, 510623, China
Contact Phone: •••-•••-•••• Email: •••••@•••••