Gene therapy shot could end monthly eye injections for wet AMD

NCT ID NCT07317934

Recruiting now Disease control Sponsor: Innostellar Biotherapeutics Co.,Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This Phase 3 trial tests a single injection of LX102 gene therapy under the retina for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. About 332 participants will receive either LX102 or standard aflibercept injections. The goal is to see if LX102 can maintain or improve vision while reducing the need for repeated treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LX102 (a gene therapy given as a single injection under the retina)
What this could lead to: If successful, this could offer a one-time treatment for wet AMD, potentially reducing the need for frequent eye injections.
What could go wrong: This is an early Phase 3 trial, so results are not yet proven. Gene therapy carries risks like inflammation or retinal damage, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD) WET AMD

Contacts and locations

Locations

Aier Eye Hospital Group Co., LTD. Changsha Aier Eye Hospital
RECRUITING

Changsha, Hunan, 410015, China
Beijing Aier-Intech Eye Hospital
RECRUITING

Beijing, Beijing Municipality, 100000, China
Beijing Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Central Theater Command General Hospital of PLA
RECRUITING

Wuhan, Hubei, 430060, China
Eye & ENT Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200031, China
Hebei Eye Hospital
RECRUITING

Xingtai, Hebei, 054000, China
Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong
RECRUITING

Shantou, Guangdong, 515041, China
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100730, China
Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
Qingdao Eye Hospital Affiliated to Shandong First Medical University
RECRUITING

Qingdao, Shandong, 266071, China
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 201801, China
Shandong Eye Hospital
RECRUITING

Jinan, Shandong, 250021, China
Shanghai General Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200080, China
Shanxi Bethune Hospital
RECRUITING

Taiyuan, Shanxi, 030032, China
Shanxi Eye Hospital
RECRUITING

Taiyuan, Shanxi, 030002, China
Shenyang Fourth People's Hospital
RECRUITING

Shenyang, Liaoning, 110000, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, Sichuan, 646100, China
Southwest Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400038, China
The Affiliated Eye Hospital of Nanjing Medical University
RECRUITING

Nanjing, Jiangsu, 210029, China
The Eye Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325027, China
The First Affiliated Hospital of Air Force Medical University
RECRUITING

Xi’an, Shanxi, 710032, China
The First Affiliated Hospital of Jinan University
RECRUITING

Guangzhou, Guangdong, 510632, China
The First Affiliated Hospital of University of Science and Technology of China
RECRUITING

Hefei, Anhui, 230601, China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400010, China
The Second Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, Heilongjiang, 150001, China
The Second Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130022, China
The Second Xiangya Hospital, Central South University
RECRUITING

Changsha, Hunan, 410011, China
Tianjin Eye Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Tianjin Medical University Eye Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300384, China
Tongji Hospital Tongji Medical College of HUST
RECRUITING

Wuhan, Hubei, 430030, China
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Xi 'an People's Hospital (Xi 'an No.4 Hospital)
RECRUITING

Xi’an, Shanxi, 710004, China
Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200092, China
Xuzhou First People's Hospital
RECRUITING

Xuzhou, Jiangsu, 221002, China
Zhejiang Provincial People's Hospital
RECRUITING

Hangzhou, Zhejiang, 310014, China
Zhongshan Ophthalmic Center, Sun Yat-sen University
RECRUITING

Zhongshan, Guangdong, 510623, China

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