New radiation therapy aims to slow advanced prostate cancer

NCT ID NCT06520345

Recruiting now Disease control Sponsor: Telix Pharmaceuticals (Innovations) Pty Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether adding a targeted radiation drug (lutetium-177 rosopatamab) to standard care can help men with a specific type of advanced prostate cancer that has stopped responding to hormone therapy. The study will enroll 520 men across multiple countries. Participants are randomly assigned to receive either the radiation drug plus standard care or standard care alone. The main goal is to see if the combination delays cancer growth or death.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lutetium-177 rosopatamab tetraxetan (a targeted radiation drug)
What this could lead to: If successful, this could provide a new treatment option that slows cancer progression and extends survival for men with advanced prostate cancer that has stopped responding to hormone therapy.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The radiation drug may cause side effects like fatigue, low blood counts, or kidney issues, and it may not work better than standard care alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Contacts and locations

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Locations

Ankara Bilkent City Hospital
NOT_YET_RECRUITING

Ankara, Turkey (Türkiye)
Ankara University Cebeci Hospital
RECRUITING

Ankara, Turkey (Türkiye)
Auckland City Hospital
RECRUITING

Grafton, Auckland, 92024, New Zealand
Austin Health
RECRUITING

Heidelberg, 3084, Australia
Australian Prostate Centre
RECRUITING

Melbourne, Victoria, 3051, Australia

Contact Email: •••••@•••••
Biogenix Molecular LLC
ACTIVE_NOT_RECRUITING

Miami, Florida, 33165, United States
Chao Family Comprehensive Cancer Centre
ACTIVE_NOT_RECRUITING

Orange, California, 92868, United States
Charing Cross Hospital
RECRUITING

London, United Kingdom
Columbia University Herbert Irving Comphrensive Cancer Center
RECRUITING

New York, New York, 10032, United States
GenesisCare Maitland
RECRUITING

East Maitland, 2323, Australia
GenesisCare Murdoch
RECRUITING

Perth, Western Australia, 6150, Australia
GenesisCare North Adelaide
RECRUITING

North Adelaide, 5006, Australia
GenesisCare Tugun
RECRUITING

Tugun, 4224, Australia
Genesiscare Windsor
RECRUITING

Windsor, United Kingdom

Contact Email: •••••@•••••
GensisCare Cabrini
RECRUITING

Malvern, 3144, Australia
Hacettepe University Medical Faculty
RECRUITING

Ankara, Turkey (Türkiye)
INITIO Medical Group
RECRUITING

Burnaby, Canada

Contact Email: •••••@•••••
Intermountain Health
ACTIVE_NOT_RECRUITING

Murray, Utah, 84107, United States
Intermountain Health
ACTIVE_NOT_RECRUITING

Salt Lake City, Utah, 84112, United States
Maslak Acibadem Hospital
RECRUITING

Istanbul, Turkey (Türkiye)
Mater Health Services Pty Ltd
NOT_YET_RECRUITING

Brisbane, 4101, Australia
Nepean Hospital
RECRUITING

Sydney, New South Wales, 2747, Australia
New Zealand Clinical Research - Christchurch
RECRUITING

Christchurch, 8011, New Zealand
OHSU Knight Cancer Center
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
Royal Free Hospital
NOT_YET_RECRUITING

London, United Kingdom
Royal North Shore Hospital
RECRUITING

Saint Leonards, 2065, Australia
Sunnybrook Research Institute
RECRUITING

Toronto, Canada
United Theranostics
ACTIVE_NOT_RECRUITING

Glen Burnie, Maryland, 21061, United States
University College London Hospitals
RECRUITING

London, United Kingdom
University Hospital
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44106, United States
Westmead Hospital
RECRUITING

Sydney, New South Wales, 2143, Australia
Wollongong Hospital
RECRUITING

Wollongong, New South Wales, 2500, Australia
XCancer Omaha
ACTIVE_NOT_RECRUITING

Omaha, Nebraska, 68130, United States

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