New hope for Tough-to-Treat lung cancer: major trial tests drug combo

NCT ID NCT05973773

Summary

This study is testing if adding a new drug called zipalertinib to standard chemotherapy works better than chemotherapy alone for people with advanced non-small cell lung cancer that has a specific genetic change (EGFR exon 20 insertion). The goal is to see if the combination can better control the cancer's growth and spread. About 285 adults who haven't had prior treatment for their advanced cancer will participate globally.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Actualidad Basada en la Investigación del Cáncer

    Guadalajara, Jalisco, 44680, Mexico

  • Aichi Cancer Center

    Nagoya, Aiti [Aichi], 464-8681, Japan

  • Ajou University Hospital

    Suwon, Gyeonggi-do, 16499, South Korea

  • Algemeen Ziekenhuis Delta - Campus Menen

    Menen, West Flanders, 8930, Belgium

  • Algemeen Ziekenhuis Delta - Campus Rumbeke

    Rosières, West-Vlaanderen, 8800, Belgium

  • Algemeen Ziekenhuis Maria Middelares

    Ghent, Oost-Vlaaderen, 9000, Belgium

  • Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve Arastirma Hastanesi

    Etlik, 06010, Turkey (Türkiye)

  • Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde"

    Guadalajara, Jalisco, 44280, Mexico

  • Antoni Van Leeuwenhoek Ziekenhuis

    Amsterdam, North Holland, 1066 CX, Netherlands

  • Asian Hospital and Medical Center

    City of Muntinlupa, 1780, Philippines

  • Asklepios Klinik Altona

    Hamburg, Hamburg (Hansestadt), 22763, Germany

  • Assuta Hospital - Ramat HaHayal

    Tel Aviv, 69710, Israel

  • Azienda Ospedaliera Universitaria Integrata Verona

    Verona, 37126, Italy

  • Azienda Ospedaliero - Universitaria di Modena

    Modena, 41224, Italy

  • Azienda Unità Sanitaria Locale della Romagna

    Ravenna, 48121, Italy

  • BC Cancer Vancouver

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Bagcilar Medipol Mega Universite Hastanesi

    Istanbul, 34214, Turkey (Türkiye)

  • BioClinic Thessaloniki

    Thessaloniki, 54622, Greece

  • CH Cornouaille Quimper

    Quimper, 29000, France

  • Cancer Institute Hospital of JFCR

    Koto, Tokyo, 135-8550, Japan

  • Catholic University of Korea Saint Vincent's Hospital

    Suwon, Gyeonggi-do, 16247, South Korea

  • Centre Hospitalier Le Mans

    Le Mans, Pays de la Loire Region, 72037, France

  • Centre Hospitalier Universitaire Limoges

    Limoges, Limousin, 87042, France

  • Centro Regional Integrado de Oncologia

    Fortaleza, Ceará, 60335-480, Brazil

  • CentroEstudiosClinicosSAGA

    Santiago, Region de Santiago, 7500653, Chile

  • Centrul de Oncologie Sf Nectarie

    Craiova, Dolj, 200746, Romania

  • Clinica SIGMedical

    Suceava, 720214, Romania

  • Clínica Integral Internacional de Oncología S de RL de CV

    Mirador, Puebla, 72530, Mexico

  • Clínica Mi Tres Torres

    Barcelona, 08017, Spain

  • Clínica Neoplasias Litoral

    Itajaí, Santa Catatina, 88301, Brazil

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, La Coruña, 15006, Spain

  • Comprehensive Cancer Centers of Nevada - Central Valley - Twain

    Las Vegas, Nevada, 89169, United States

  • Comprehensive Cancer Centers of Nevada - Henderson

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada - Horizon Ridge Henderson

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada, 89218, United States

  • Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie

    Henderson, Nevada, 89074, United States

  • Comprehensive Cancer Centers of Nevada - Southwest

    Las Vegas, Nevada, 89148, United States

  • Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II

    Las Vegas, Nevada, 89144, United States

  • Emek Medical Center

    Afula, 18101, Israel

  • FAICIC Clínical Research

    Veracruz, 91900, Mexico

  • Faculty of Medicine Siriraj Hospital

    Bang Phlat, Bangkok, 10700, Thailand

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Gabrail Cancer and Research Center

    Canton, Ohio, 44718, United States

  • General Hospital for Thoracic Diseases Sotiria

    Athens, Attica, 11527, Greece

  • Gustave Roussy

    Villejuif, Val-de-Marne, 94805, France

  • Gyeongsang National University Hospital

    Jinju, Gyeongsangnamdo [Kyongsangnam-do], 52727, South Korea

  • Hacettepe Üniversitesi Kanser Enstitüsü

    Ankara, 06010, Turkey (Türkiye)

  • Hadassah University Hospital Ein Kerem

    Jerusalem, 9112001, Israel

  • Health Pharma Professional Research S.A. De C.V

    Mexico City, Mexico City, 3100, Mexico

  • Hirosaki University Hospital

    Hirosaki-Shi, Aomori, 036-8563, Japan

  • Hospital Amaral Carvalho

    Jaú, São Paulo, 17210-180, Brazil

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clínico Universidad de Chile

    Independencia, Santiago Metropolitan, 8380494, Chile

  • Hospital Mãe de Deus - Centro Integrado de Oncologia

    Porto Alegre, Rio Grande do Sul, 90110-270, Brazil

  • Hospital Quirónsalud Barcelona

    Barcelona, 08023, Spain

  • Hospital Regional Universitario de Málaga - Hospital General

    Málaga, 29010, Spain

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario de Jaén

    Jaén, 23007, Spain

  • Hôpital Ambroise-Paré

    Boulogne-Billancourt, Île-de-France Region, 92100, France

  • Hôpital Côte De Nacre

    Caen, Basse-Normandie, 14033, France

  • Hôpital Haut-Lévêque

    Pessac, Nouvelle-Aquitaine, 33604, France

  • IRCCS Istituto Nazionale Tumori Regina Elena

    Roma, 1444, Italy

  • Icon Cancer Centre - Mount Alvernia

    Singapore, 228510, Singapore

  • Icon Cancer Centre Mount Elizabeth

    Singapore, 574623, Singapore

  • Inha University Hospital

    Incheon, Incheon Gwang'yeogsi [Inch'on-Kwangyokshi], 22332, South Korea

  • Institut Curie

    Paris, Île-de-France Region, 75248, France

  • Instituto Oncológico Fundación Arturo López Pérez

    Providencia, Santiago Metropolitan, 7500921, Chile

  • Instytut MSF

    Lodz, Lódzkie, 90-302, Poland

  • Investigacion Medica Galerias

    Aguascalientes, 20124, Mexico

  • Istituto Nazionale per la Ricerca sul Cancro

    Genova, Genoa, 16132, Italy

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST

    Meldola, Forli-Cesena, 47014, Italy

  • Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST

    Meldola, Forlì-Cesena, 47014, Italy

  • Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele

    Milan, 20132, Italy

  • Kanagawa Cardiovascular and Respiratory Center

    Yokohama, Kanagawa, 236-0051, Japan

  • Kanazawa University Hospital

    Kanazawa, 920-8641, Japan

  • Kansai Medical University Hospital

    Hirakata, Osaka, 573-1191, Japan

  • Keio University Hospital

    Shinjuku-Ku, Tokyo, 160-8582, Japan

  • King Chulalongkorn Memorial Hospital

    Pathum Wan, Bangkok, 10330, Thailand

  • Kitasato University Hospital

    Sagamihara, Kanagawa, 252-0375, Japan

  • Korea University Anam Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 02841, South Korea

  • Korea University Guro Hospital

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 08308, South Korea

  • Kyushu Cancer Center

    Fukuoka, Hukuoka, 811-1395, Japan

  • LMU Klinikum - Campus Innenstadt

    München, 80337, Germany

  • Les Hôpitaux Universitaires de Strasbourg

    Strasbourg, Alsace, 67091, France

  • MD Anderson Cancer Center Madrid

    Madrid, 28033, Spain

  • Medical Park Seyhan Hastanesi

    Adana, 01120, Turkey (Türkiye)

  • Medisprof

    Cluj-Napoca, Cluj, 400641, Romania

  • Memorial Ankara Hastanesi

    Ankara, 6520, Turkey (Türkiye)

  • Metropolitan General

    Piraeus, Attica, 18547, Greece

  • Metropolitan Hospital

    Piraeus, Pireas, 185 47, Greece

  • National Cancer Centre Singapore

    Singapore, 168583, Singapore

  • National Hospital Organization Kinki-Chuo Chest Medical Center

    Sakai-Shi, Osaka, 591-8555, Japan

  • Navamindradhiraj University - Faculty of Medicine Vajira Hospital

    Bangkok, Khet Dusit, 10300, Thailand

  • Nottingham University Hospitals NHS Trust

    Nottingham, England, NG5 1PB, United Kingdom

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Oncocare Cancer Centre

    Singapore, 308900, Singapore

  • Oncocenter - Oncologie Clinica

    Timișoara, Timiș County, 300166, Romania

  • Osaka City General Hospital

    Osaka, 534-0021, Japan

  • Osaka Prefectural Hospital Organization - Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Radboud Universitair Medisch Centrum

    Nijmegen, Gelderland, 6525 GA, Netherlands

  • Royal Free London NHS Foundation Trust

    London, England, NW3 2QG, United Kingdom

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861-4163, Japan

  • Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

    Lublin, Lublin Voivodeship, 20-954, Poland

  • Sendai Kousei Hospital

    Sendai, Miyagi, 980-0873, Japan

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, South Korea

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • St. Luke's Medical Center - Quezon City

    Quezon City, Metropolitan Manila, 1112, Philippines

  • T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

    Istanbul, 34722, Turkey (Türkiye)

  • T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi

    Adana, 01060, Turkey (Türkiye)

  • T.C. Saglik Bakanligi Ankara Bilkent Sehi?r Hastanesi?

    Çankaya, 06800, Turkey (Türkiye)

  • Tan Tock Seng Hospital

    Singapore, 30433, Singapore

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • The Medical City

    Pasig, National Capital Region, 1605, Philippines

  • Torbay and South Devon NHS Foundation Trust

    Torquay, England, TQ2 7AA, United Kingdom

  • Trakya Üniversitesi Sa?l?k Ara?t?rma ve Uygulama Merkezi

    Edirne, 22130, Turkey (Türkiye)

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, Flemish Brabant, 3000, Belgium

  • University General Hospital of Larissa

    Larissa, Thessaly, 41110, Greece

  • University General Hospital of Patras

    Patra, Peloponnese, 26504, Greece

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Universitätsklinikum Gießen und Marburg - Gießen

    Giessen, Hesse, 35392, Germany

  • Universitätsklinikum Regensburg

    Regensburg, 93053, Germany

  • Vrije Universiteit Medisch Centrum

    Amsterdam, North Holland, 1081 HV, Netherlands

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandów

    Pozna?, Greater Poland Voivodeship, 60-569, Poland

  • William Osler Health System - Brampton Civic Hospital

    Brampton, Ontario, L6R 3J7, Canada

Conditions

Explore the condition pages connected to this study.