New hope for Tough-to-Treat lung cancer? trial tests combo therapy

NCT ID NCT01933932

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new drug called selumetinib to standard chemotherapy (docetaxel) works better than chemotherapy alone for people with advanced non-small cell lung cancer that has a specific KRAS mutation and has worsened after initial treatment. It involved 510 participants and aimed to see if the combination could better control the cancer's growth, help patients live longer, and improve their symptoms. The trial was a Phase 3 study, meaning it was a large, late-stage test to see if the treatment is effective and safe.

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Contacts and locations

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Locations

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Aurora, Colorado, 80045, United States
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Pembroke Pines, Florida, 33028, United States
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Atlanta, Georgia, 30318, United States
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Chicago, Illinois, 60637, United States
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Metairie, Louisiana, 70006, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02215, United States
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Danvers, Massachusetts, 01923, United States
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New York, New York, 10011, United States
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New York, New York, 10032, United States
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Durham, North Carolina, 27710, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19107, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Seattle, Washington, 98104, United States
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Morgantown, West Virginia, 26506, United States
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Buenos Aires, 1426, Argentina
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Ciudad de Buenos Aires, 1180, Argentina
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Ciudad de Buenos Aires, C1025ABI, Argentina
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Córdoba, 5000, Argentina
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Rosario, S2000KZE, Argentina
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Camperdown, 2050, Australia
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Chermside, 4032, Australia
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Darlinghurst, 2010, Australia
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Fitzroy, 3065, Australia
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Kogarah, 2217, Australia
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Kurralta Park, 5037, Australia
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Malvern, 3144, Australia
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Wendouree, 3355, Australia
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Woodville South, 5011, Australia
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Salzburg, 5020, Austria
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Vienna, 1100, Austria
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Vienna, 1160, Austria
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Brussels, 1000, Belgium
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Brussels, 1090, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Roeselare, 8800, Belgium
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Barretos, 14784-400, Brazil
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Ijuí, 98700-000, Brazil
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Pelotas, 096015-280, Brazil
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Porto Alegre, 90035-003, Brazil
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Porto Alegre, 90610-000, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01209-000, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, Brazil
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Plovdiv, 4000, Bulgaria
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Sofia, 1233, Bulgaria
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Sofia, 1303, Bulgaria
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Sofia, 1330, Bulgaria
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Varna, 9010, Bulgaria
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Vratsa, 3000, Bulgaria
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Edmonton, Alberta, T6G 1Z2, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Surrey, British Columbia, V3V 1Z2, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Regina, Saskatchewan, S4T 7T1, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Santiago, 7500921, Chile
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Santiago, 7520349, Chile
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Santiago, 7630370, Chile
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Santiago, 8360160, Chile
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Santiago, 8380456, Chile
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Santiago, 8420383, Chile
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Brest, 29609, France
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Caen, F-14033, France
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Clermont-Ferrand, 63003, France
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Dijon, 21079, France
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Lille, 59000, France
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Marseille, 13915, France
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Paris, 75020, France
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Pierre-Bénite, 69310, France
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Rennes, 35033, France
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Toulouse, 31059, France
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Augsburg, 86156, Germany
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Bad Berka, 99437, Germany
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Cologne, 50937, Germany
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Dortmund, 44309, Germany
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Gerlingen, 70839, Germany
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Großhansdorf, 22927, Germany
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Halle, 06120, Germany
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Heidelberg, 69126, Germany
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Homburg, 66424, Germany
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Löwenstein, 74245, Germany
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Moers, 47441, Germany
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München, 81925, Germany
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Ulm, 89081, Germany
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Wiesbaden, 65199, Germany
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Würzburg, 97080, Germany
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Budapest, 1121, Hungary
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Budapest, 1122, Hungary
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Edelény, 3780, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Miskolc, 3529, Hungary
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Nyíregyháza, 4400, Hungary
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Törökbálint, 2045, Hungary
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Beersheba, 8410101, Israel
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Haifa, 31096, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 64239, Israel
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Tel Litwinsky, 52621, Israel
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Bari, 70124, Italy
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Genova, 16100, Italy
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Livorno, 57100, Italy
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Milan, 20132, Italy
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Napoli, 80131, Italy
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Orbassano, 10043, Italy
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Parma, 43126, Italy
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Perugia, 06132, Italy
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Roma, 00128, Italy
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Roma, 00144, Italy
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México, 14080, Mexico
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Monterrey, 64460, Mexico
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's-Hertogenbosch, 5223 GZ, Netherlands
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Amsterdam, 1066 CX, Netherlands
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Amsterdam, 1081 HV, Netherlands
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Bergen op Zoom, 4624 VT, Netherlands
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Maastricht, 6202 AZ, Netherlands
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Lima, 15033, Peru
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Lima, 15073, Peru
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Lima, L27, Peru
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Lima, LIMA 01, Peru
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Lima, LIMA 11, Peru
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Lima, LIMA 29, Peru
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Lima, LIMA 34, Peru
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Miraflores, 15046, Peru
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Brzozów, 36-200, Poland
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Bydgoszcz, 85-796, Poland
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Gdansk, 80-219, Poland
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Gdansk, 80-952, Poland
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Grudziądz, 86-300, Poland
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Krakow, 31-202, Poland
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Lubin, 59-301, Poland
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Olsztyn, 10-357, Poland
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Opole, 45-061, Poland
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Sucha Beskidzka, 34-200, Poland
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Szczecin, 70-891, Poland
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Warsaw, 02-781, Poland
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Amadora, 2720-276, Portugal
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Coimbra, 3040-316, Portugal
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Lisbon, 1099-023, Portugal
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Lisbon, 1769-001, Portugal
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Porto, 4100-180, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Cluj-Napoca, 400015, Romania
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Cluj-Napoca, 400058, Romania
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Kazan', 420012, Russia
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Moscow, 105229, Russia
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Moscow, 115478, Russia
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Saint Petersburg, 194291, Russia
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Saint Petersburg, 197342, Russia
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Saint Petersburg, 197758, Russia
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Volgograd, 400138, Russia
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Barcelona, 08003, Spain
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Madrid, 08035, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Málaga, 29010, Spain
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Seville, 41013, Spain
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Vigo(Pontevedra), 36204, Spain
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Zaragoza, 50009, Spain
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Linköping, 581 85, Sweden
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Örebro, 701 85, Sweden
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Uppsala, SE-751 85, Sweden
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Ankara, 06230, Turkey (Türkiye)
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Ankara, 06280, Turkey (Türkiye)
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Istanbul, 34662, Turkey (Türkiye)
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Istanbul, 34844, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35110, Turkey (Türkiye)
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Manisa, 45030, Turkey (Türkiye)
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Chernivtsі, 58013, Ukraine
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Dnipro, 49102, Ukraine
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Kharkiv Region, 61070, Ukraine
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Kryvyi Rih, 50048, Ukraine
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Kyiv, 03115, Ukraine
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Sumy, 40022, Ukraine
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Uzhhorod, 88000, Ukraine
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Zaporizhzhia, 69040, Ukraine
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Aberdeen, AB2 2ZB, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom

Conditions

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LOCALLY ADVANCED OR METASTATIC NON SMALL CELL LUNG CANCER STAGE IIIB - IV