New drug combo challenges standard for Tough-to-Treat lung cancer

NCT ID NCT06008093

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing if a new combination of two immunotherapy drugs (durvalumab and tremelimumab) plus chemotherapy helps people with advanced non-small cell lung cancer live longer than the current standard treatment (pembrolizumab plus chemotherapy). It is specifically for patients whose cancer has certain genetic mutations (STK11, KEAP1, or KRAS) that can make treatment less effective. About 280 participants will be randomly assigned to receive one of the two treatment combinations.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Birmingham, Alabama, 35233, United States
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Anchorage, Alaska, 99508, United States
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Chandler, Arizona, 85224, United States
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Tucson, Arizona, 85724, United States
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Beverly Hills, California, 90211, United States
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Irvine, California, 92618, United States
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La Jolla, California, 92093, United States
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Loma Linda, California, 92357, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90034, United States
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Los Angeles, California, 90095, United States
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Redding, California, 96001, United States
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Santa Monica, California, 90404, United States
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Denver, Colorado, 80218, United States
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Wheat Ridge, Colorado, 80033, United States
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Washington D.C., District of Columbia, 20007, United States
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Washington D.C., District of Columbia, 20010, United States
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Fort Lauderdale, Florida, 33308, United States
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Jupiter, Florida, 33458, United States
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Ocala, Florida, 34474, United States
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Orlando, Florida, 32804, United States
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St. Petersburg, Florida, 33705, United States
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Tampa, Florida, 33607, United States
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Tampa, Florida, 33612, United States
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Albany, Georgia, 31701, United States
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Atlanta, Georgia, 30303, United States
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Atlanta, Georgia, 30318, United States
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Atlanta, Georgia, 30322, United States
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Columbus, Georgia, 31904, United States
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Honolulu, Hawaii, 96813, United States
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Carterville, Illinois, 62918, United States
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Chicago, Illinois, 60607, United States
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Chicago, Illinois, 60612, United States
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Maywood, Illinois, 60153, United States
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Urbana, Illinois, 61801, United States
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Dyer, Indiana, 46311, United States
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Evansville, Indiana, 47713, United States
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Westwood, Kansas, 66205, United States
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Lexington, Kentucky, 40502, United States
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Louisville, Kentucky, 40206, United States
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Bethesda, Maryland, 20817, United States
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Jamaica Plain, Massachusetts, 02130, United States
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Worcester, Massachusetts, 01655, United States
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Detroit, Michigan, 48201, United States
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Farmington Hills, Michigan, 48334, United States
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Lansing, Michigan, 48912, United States
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Traverse City, Michigan, 49684, United States
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Saint Paul, Minnesota, 55101, United States
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Kansas City, Missouri, 64111, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63128, United States
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Billings, Montana, 59102, United States
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Grand Island, Nebraska, 68803, United States
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Lincoln, Nebraska, 68506, United States
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Albany, New York, 12206, United States
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Clifton Park, New York, 12065, United States
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East Syracuse, New York, 13057, United States
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Mineola, New York, 11501, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10016, United States
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New York, New York, 10028, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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Northport, New York, 11768, United States
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Shirley, New York, 11967, United States
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Stony Brook, New York, 11790, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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The Bronx, New York, 10469, United States
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Westbury, New York, 11590, United States
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Bismarck, North Dakota, 58501, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44124, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Dayton, Ohio, 45459, United States
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Maumee, Ohio, 43537, United States
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Perrysburg, Ohio, 43551, United States
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Toledo, Ohio, 43623, United States
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Norman, Oklahoma, 73072, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19111, United States
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Philadelphia, Pennsylvania, 19131, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Providence, Rhode Island, 02906, United States
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Sioux Falls, South Dakota, 57105, United States
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Memphis, Tennessee, 38104, United States
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Memphis, Tennessee, 38104, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37212, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75246, United States
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Dallas, Texas, 75246, United States
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Denton, Texas, 76210, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77090, United States
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Kingwood, Texas, 77339, United States
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San Antonio, Texas, 78212, United States
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San Antonio, Texas, 78229, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Richmond, Virginia, 23298, United States
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Milwaukee, Wisconsin, 53215, United States

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG