Major trial aims to stop early lung cancer from coming back

NCT ID NCT03833154

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing if adding a drug to standard radiation treatment can better control early-stage lung cancer that cannot be surgically removed. For most participants, the drug is an immunotherapy (durvalumab) given alongside precise radiation. For a smaller group with a specific genetic marker (EGFR mutation), the study tests a targeted drug (osimertinib) taken after radiation. The main goal is to see if these approaches help keep the cancer from progressing or returning for a longer time.

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Contacts and locations

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Locations

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Tuscaloosa, Alabama, 35401, United States
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Chandler, Arizona, 85224, United States
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Phoenix, Arizona, 85004, United States
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Tucson, Arizona, 85719, United States
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Duarte, California, 91010, United States
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Long Beach, California, 90806, United States
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Los Angeles, California, 90095, United States
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San Diego, California, 92123, United States
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Newark, Delaware, 10709, United States
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Washington D.C., District of Columbia, 20010, United States
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Bay Pines, Florida, 33744, United States
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Jacksonville, Florida, 32256, United States
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Miami Beach, Florida, 33140, United States
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Orlando, Florida, 32804, United States
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Atlanta, Georgia, 30322, United States
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Atlanta, Georgia, 30342, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60612, United States
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Chicago, Illinois, 60637, United States
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Decatur, Illinois, 62526, United States
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Elmhurst, Illinois, 60126, United States
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Naperville, Illinois, 60540, United States
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Fort Wayne, Indiana, 46845, United States
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Cedar Rapids, Iowa, 52403, United States
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Iowa City, Iowa, 52242, United States
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Elizabethtown, Kentucky, 42701, United States
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Lexington, Kentucky, 40503, United States
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Louisville, Kentucky, 40202, United States
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Metairie, Louisiana, 70006, United States
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New Orleans, Louisiana, 70121, United States
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South Portland, Maine, 04106, United States
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Annapolis, Maryland, 21401, United States
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Baltimore, Maryland, 21201, United States
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Rosedale, Maryland, 21237, United States
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Silver Spring, Maryland, 20910, United States
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Towson, Maryland, 21204, United States
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Boston, Massachusetts, 02215, United States
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Ann Arbor, Michigan, 48197, United States
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Detroit, Michigan, 48201, United States
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Royal Oak, Michigan, 48073, United States
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Duluth, Minnesota, 55805, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Omaha, Nebraska, 68105, United States
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Las Vegas, Nevada, 89135, United States
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Lebanon, New Hampshire, 03756, United States
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Camden, New Jersey, 08103, United States
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Paramus, New Jersey, 07652, United States
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Albany, New York, 12206, United States
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East Syracuse, New York, 13057, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10016, United States
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Rochester, New York, 14642, United States
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Stony Brook, New York, 11794, United States
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Syracuse, New York, 13210, United States
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The Bronx, New York, 10461, United States
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The Bronx, New York, 10467, United States
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Winston-Salem, North Carolina, 27157, United States
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Grand Forks, North Dakota, 58201, United States
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Akron, Ohio, 44304, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45242, United States
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Cleveland, Ohio, 44106, United States
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Portland, Oregon, 97210, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Charleston, South Carolina, 29425, United States
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Sioux Falls, South Dakota, 57105, United States
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Watertown, South Dakota, 57201, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75235, United States
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Houston, Texas, 77030, United States
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Sherman, Texas, 75090, United States
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Burlington, Vermont, 05401, United States
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Richmond, Virginia, 23249, United States
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Bellingham, Washington, 98225, United States
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Seattle, Washington, 98195, United States
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Spokane Valley, Washington, 99216, United States
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Milwaukee, Wisconsin, 53226, United States
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Clayton, 3168, Australia
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Aalst, 9300, Belgium
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Charleroi, 6000, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Barretos, 14784-400, Brazil
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Porto Alegre, 90110-270, Brazil
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Recife, 52010-075, Brazil
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Rio de Janeiro, 22271-110, Brazil
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São Paulo, 01327-001, Brazil
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Volta Redonda, 27258-000, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Beijing, 100021, China
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Beijing, 100142, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610042, China
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Fuzhou, 350005, China
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Hangzhou, 310002, China
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Hangzhou, 310022, China
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Hefei, 230031, China
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Jinan, 250117, China
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Nanjing, 210009, China
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Shanghai, 200002, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200433, China
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Shenyang, 100003, China
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Suzhou, 215006, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Zhengzhou, 450008, China
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Bron, 69677, France
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Dijon, 21079, France
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Lyon, 69317, France
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Nantes, 44202, France
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Pierre-Bénite, 69310, France
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Toulouse, 31000, France
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Villejuif, 94805, France
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Dresden, 01307, Germany
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Göttingen, 37075, Germany
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Halle, 06120, Germany
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Hanover, 30459, Germany
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Heidelberg, 69126, Germany
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Homburg, 66424, Germany
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Regensburg, 93053, Germany
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Trier, 54292, Germany
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Athens, 11526, Greece
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Athens, 11527, Greece
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Thessaloniki, 55236, Greece
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Haifa, 31096, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 95847, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 64239, Israel
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Florence, 50134, Italy
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Genova, 16132, Italy
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Milan, 20132, Italy
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Orbassano, 10043, Italy
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Padua, 35128, Italy
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Pavia, 27100, Italy
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Roma, 00128, Italy
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Rozzano, 20089, Italy
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Akashi-shi, 673-8558, Japan
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Bunkyō City, 113-8677, Japan
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hirosaki-shi, 036-8563, Japan
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Hiroshima, 734-8551, Japan
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Kobe, 650-0047, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakaishi, 591-8555, Japan
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Sapporo, 060-8648, Japan
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Sunto-gun, 411-8777, Japan
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Toyoake-shi, 470-1192, Japan
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Yokohama, 241-8515, Japan
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Amsterdam, 1081 HV, Netherlands
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Groningen, 9713 GZ, Netherlands
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Utrecht, 3584 CX, Netherlands
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Bydgoszcz, 85-796, Poland
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Elblag, 02-300, Poland
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Gdansk, 80-952, Poland
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Katowice, 40-514, Poland
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Lodz, 93-513, Poland
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Warsaw, 02-781, Poland
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Hato Rey, 00917, Puerto Rico
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Kazan, Tatarstan, 420029, Russia
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Moscow, 105229, Russia
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Moscow, 115478, Russia
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Moscow, 119421, Russia
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Saint Petersburg, 197758, Russia
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Ufa, 450054, Russia
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Yekaterinburg, 620905, Russia
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Cheongju-si, 28644, South Korea
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Goyang-si, 10408, South Korea
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Gyeonggi-do, 13620, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Badajoz, 6006, Spain
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Barcelona, 08041, Spain
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L'Hospitalet de Llobregat, 08907, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Málaga, 29010, Spain
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San Sebastián, 20014, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41013, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Istanbul, 34214, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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Kocaeli, 41400, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, EC1A 7BE, United Kingdom
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Manchester, M20 4BX, United Kingdom

Conditions

Explore the condition pages connected to this study.

CARCINOMA, NON-SMALL-CELL LUNG