New hope for Tough-to-Treat lung cancer: experimental combo challenges standard care

NCT ID NCT05450692

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is for people with advanced non-small cell lung cancer that has continued to grow despite previous immunotherapy and chemotherapy. It compares a new two-drug combination (ceralasertib plus durvalumab) against the standard chemotherapy drug docetaxel. The main goal is to see if the new combination helps patients live longer than the standard treatment.

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Contacts and locations

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Locations

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Mobile, Alabama, 36607, United States
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Chandler, Arizona, 85224, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90017, United States
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Whittier, California, 90603, United States
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Jacksonville, Florida, 32256, United States
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Orlando, Florida, 32804, United States
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Tampa, Florida, 33612, United States
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Athens, Georgia, 30607, United States
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Atlanta, Georgia, 30318, United States
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Fort Wayne, Indiana, 46804, United States
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Baltimore, Maryland, 21231, United States
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Bethesda, Maryland, 20817, United States
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Rockville, Maryland, 20852, United States
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Hattiesburg, Mississippi, 39401, United States
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St Louis, Missouri, 63110, United States
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Omaha, Nebraska, 68114, United States
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Reno, Nevada, 89511, United States
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Charlotte, North Carolina, 28204, United States
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Winston-Salem, North Carolina, 27103, United States
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Canton, Ohio, 44718, United States
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Cleveland, Ohio, 44106, United States
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Allentown, Pennsylvania, 18103, United States
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York, Pennsylvania, 17403, United States
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Houston, Texas, 77090, United States
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Huntsville, Texas, 77340, United States
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Kingwood, Texas, 77339, United States
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Appleton, Wisconsin, 54911, United States
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Buenos Aires, 1058, Argentina
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Pergamino, B2700CPM, Argentina
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Rosario, S2000DSV, Argentina
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Rosario, S2000KZE, Argentina
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San Juan, 5400, Argentina
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Elizabeth Vale, 5112, Australia
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Lismore, 2480, Australia
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Murdoch, 6150, Australia
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South Brisbane, 4101, Australia
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Wollongong, 2500, Australia
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Charleroi, 6000, Belgium
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Ghent, 9000, Belgium
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Libramont-Chevigny, 6800, Belgium
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Roeselare, 8800, Belgium
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Fortaleza, 60810-180, Brazil
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Porto Alegre, 90110-270, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 40170-110, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 09323-900, Brazil
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Vancouver, British Columbia, VSZ 4E6, Canada
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Newmarket, Ontario, L3Y 2P9, Canada
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Chicoutimi, Quebec, G7H 7P2, Canada
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Montreal, Quebec, H2L 4M1, Canada
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Montreal, Quebec, H3G 1A4, Canada
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Québec, Quebec, G1V 4G5, Canada
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Rimouski, Quebec, G5L 5T1, Canada
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Baoding, 071000, China
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Beijing, 100021, China
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Beijing, 100044, China
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Changsha, 410008, China
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Chengdu, 610041, China
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Deyang, 618000, China
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Guangzhou, 510080, China
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Hangzhou, 310009, China
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Hefei, 230001, China
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Jinan, 250013, China
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Linyi, 276000, China
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Nanchang, 330000, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Nashik, 422011, China
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Qingdao, 266071, China
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Taiyuan, 030000, China
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Tianjin, 300052, China
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Tianjin, 300060, China
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Wuhan, 430000, China
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Wuhan, 430022, China
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Wuhan, 430079, China
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Zhanjiang, 524001, China
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Zhengzhou, 450008, China
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Angers, 49933, France
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Clamart, 92140, France
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Clermont-Ferrand, 63011, France
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Créteil, 94010, France
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Lyon, 69373, France
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Montpellier, 34070, France
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Nantes, 44093, France
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Paris, 75014, France
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Pessac, 33604, France
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Saint-Herblain, 44805, France
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Saint-Quentin, 02321, France
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Vantoux, 57070, France
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Villefranche-sur-Saône, 69655, France
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Villejuif, 94805, France
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Berlin, 12351, Germany
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Freiburg im Breisgau, 79106, Germany
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Gauting, 82131, Germany
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Karlsruhe, 76137, Germany
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Kempten, 87439, Germany
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Löwenstein, 74245, Germany
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Moers, 47441, Germany
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Hong Kong, 999077, Hong Kong
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King's Park, 150001, Hong Kong
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Tun Mun, Hong Kong
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Budapest, 1121, Hungary
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Székesfehérvár, 8000, Hungary
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Jaipur, 302017, India
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Pune, 411001, India
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Surat, 395002, India
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Cork, T12 DV56, Ireland
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Dublin, D09 V2N0, Ireland
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Dublin, Ireland
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Limerick, V94 F858, Ireland
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Aviano, 33081, Italy
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Livorno, 57124, Italy
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Monza, 20900, Italy
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Naples, 80131, Italy
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Padua, 35128, Italy
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Parma, 43126, Italy
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Perugia, 06129, Italy
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Roma, 00128, Italy
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Rozzano, 20089, Italy
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Verona, 37126, Italy
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Bunkyō City, 113-8431, Japan
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Bunkyō City, 113-8677, Japan
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Chūōku, 104-0045, Japan
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Kōtoku, 135-8550, Japan
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Kurashiki-shi, 710-8602, Japan
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Kurume-shi, 830-0011, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 460-0001, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakaishi, 591-8555, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-0873, Japan
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Sunto-gun, 411-8777, Japan
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Toyoake-shi, 470-1192, Japan
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Yokohama, 241-8515, Japan
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Heerlen, 6419 PC, Netherlands
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Tilburg, 5022 GC, Netherlands
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Gdansk, 80-952, Poland
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Krakow, 30-727, Poland
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Krakow, 31-826, Poland
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Poznan, 60-693, Poland
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Skórzewo, 60-185, Poland
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Bucharest, 022328, Romania
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Bucharest, 031422, Romania
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Cluj-Napoca, 400015, Romania
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Cluj-Napoca, 400641, Romania
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Craiova, 200347, Romania
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Craiova, 200385, Romania
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Floreşti, 407280, Romania
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Oradea, 410469, Romania
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Timișoara, 300166, Romania
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Timișoara, 300239, Romania
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Belgrade, 11080, Serbia
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Cheongju-si, 28644, South Korea
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Seoul, 03080, South Korea
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Seoul, 03181, South Korea
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Seoul, 03722, South Korea
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Seoul, 07061, South Korea
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Seoul, 138-736, South Korea
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Suwon, 16247, South Korea
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A Coruña, 15006, Spain
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A Coruña, 15009, Spain
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Barcelona, 08041, Spain
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Barcelona, 8003, Spain
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Barcelona, 8035, Spain
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Castellon, 12002, Spain
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Córdoba, 14004, Spain
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Hospitalet deLlobregat, 08907, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Málaga, 29009, Spain
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Ourense, 32005, Spain
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Palma de Mallorca, 07198, Spain
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Pamplona, 31008, Spain
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Pozuelo de Alarcón, 28223, Spain
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Sabadell, 08208, Spain
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Servilla, 41014, Spain
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Zaragoza, 50009, Spain
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Taichung, 40201, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan District, 333423, Taiwan
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Yunlin, 640, Taiwan
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Guildford, United Kingdom
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Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Stevenage, SG1 4AB, United Kingdom
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Sutton, SM2 5PT, United Kingdom

Conditions

Explore the condition pages connected to this study.

ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER