Major trial tests new drug combo in fight against spreading lung cancer

NCT ID NCT05984277

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is comparing two different drug combinations for people with advanced non-small cell lung cancer that has spread. About 1200 participants will receive either a new drug called volrustomig plus standard chemotherapy, or an existing drug called pembrolizumab plus the same chemotherapy. The main goal is to see which combination helps patients live longer without their cancer getting worse.

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Contacts and locations

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Locations

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Prescott, Arizona, 86301, United States
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Hot Springs, Arkansas, 71913, United States
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Springdale, Arkansas, 72762, United States
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Long Beach, California, 90806, United States
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Lone Tree, Colorado, 80124, United States
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Fort Myers, Florida, 33901, United States
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Gainesville, Florida, 32610, United States
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Orlando, Florida, 32827, United States
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St. Petersburg, Florida, 33705, United States
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West Palm Beach, Florida, 33401, United States
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Fort Wayne, Indiana, 46804, United States
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Indianapolis, Indiana, 46202, United States
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Des Moines, Iowa, 50309, United States
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Lexington, Kentucky, 40503, United States
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Louisville, Kentucky, 40206, United States
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Annapolis, Maryland, 21401, United States
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Baltimore, Maryland, 21201, United States
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Silver Spring, Maryland, 20904, United States
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Towson, Maryland, 21204, United States
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Boston, Massachusetts, 02215, United States
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Detroit, Michigan, 48202, United States
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Grand Island, Nebraska, 68803, United States
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Lincoln, Nebraska, 68506, United States
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Omaha, Nebraska, 68130, United States
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Albuquerque, New Mexico, 87102, United States
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East Syracuse, New York, 13057, United States
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Fresh Meadows, New York, 11366, United States
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Columbus, Ohio, 43210, United States
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Columbus, Ohio, 43219, United States
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Dayton, Ohio, 45428, United States
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Portland, Oregon, 97239, United States
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Horsham, Pennsylvania, 19044, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Memphis, Tennessee, 38104, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37212, United States
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Houston, Texas, 77090, United States
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Irving, Texas, 75063, United States
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Lancaster, Texas, 75216, United States
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Fairfax, Virginia, 22031, United States
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Tacoma, Washington, 98405, United States
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CABA, 1425, Argentina
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CABA, C1061, Argentina
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CABA, C1425, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5800HHW, Argentina
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La Plata, 1900, Argentina
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La Plata, B1900AVG, Argentina
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Rosario, 2000, Argentina
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Clayton, 3168, Australia
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Fitzroy, 3065, Australia
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Heidelberg, 3084, Australia
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South Brisbane, 4101, Australia
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Sydney, NSW 2145, Australia
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Linz, 4021, Austria
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Wels, 4600, Austria
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Aalst, 9300, Belgium
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Antwerp, 2020, Belgium
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Ghent, 9000, Belgium
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Barretos, 14784-400, Brazil
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Curitiba, 80730-150, Brazil
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Florianópolis, 88034-000, Brazil
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Fortaleza, 60336-045, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90619-900, Brazil
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Porto Alegre, 91350200, Brazil
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Rio de Janeiro, 22281-100, Brazil
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Santa Cruz do Sul, 96810-110, Brazil
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São Paulo, 01221-020, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Winnipeg, Manitoba, R3E 0V9, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Lévis, Quebec, G6V 3Z1, Canada
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Trois-Rivières, Quebec, G8Z 3R0, Canada
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Chicoutimi, G7H 5H6, Canada
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Beijing, 100021, China
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Beijing, 100142, China
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Beijing, 101149, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chengdu, 611135, China
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Chongqing, 400030, China
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Fuzhou, 350011, China
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Guangzhou, 510080, China
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Hangzhou, 310020, China
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Hangzhou, 310022, China
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Hefei, 230601, China
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Lanzhou, 730000, China
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Linhai, 317000, China
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Linyi, 276001, China
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Nanchang, 330006, China
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Nanchang, 330008, China
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Nanjing, 210009, China
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Nanning, 530021, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shanghai, 200433, China
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Shenzhen, 518116, China
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Taiyuan, 030000, China
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Tianjin, 300060, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Xi'an, 710000, China
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Yangzhou, 225001, China
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Zhengzhou, 450008, China
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Olomouc, 77900, Czechia
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Ostrava - Vitkovice, 703 84, Czechia
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Prague, 128 08, Czechia
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Angers, 49055, France
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Avignon, 84902, France
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Bayonne, 64100, France
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Bordeaux, 33076, France
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Caen, 14033, France
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Lille, 59037, France
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Limoges, 87042, France
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Marseille, 13273, France
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Paris, 75248, France
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Quimper, 29000, France
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Reims, 51092, France
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St-Malo, 35403, France
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Strasbourg, 67098, France
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Suresnes, 92150, France
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Toulon Naval, 83800, France
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Berlin-Zehlendorf, 14165, Germany
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Bonn, 53113, Germany
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Braunschweig, 38114, Germany
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Dresden, 01307, Germany
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Freiburg im Breisgau, 79106, Germany
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Gauting, 82131, Germany
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Georgsmarienhütte, 49124, Germany
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Gütersloh, 33332, Germany
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Halle, 06120, Germany
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Hamburg, 22087, Germany
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Heidelberg, 69126, Germany
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Immenhausen, 34376, Germany
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Koblenz, 56068, Germany
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Ludwigsburg, 71640, Germany
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Nuremberg, 90419, Germany
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Tübingen, 72076, Germany
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Velbert, 42551, Germany
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Gyöngyös, 3200, Hungary
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Gyöngyös - Mátraháza, 3200, Hungary
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Győr, 9024, Hungary
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Pécs, 7624, Hungary
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Szekszárd, 7100, Hungary
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Törökbálint, 2045, Hungary
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Bengaluru, 560085, India
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Hyderabad, 500032, India
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Kolkata, 700016, India
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Mysuru, 570017, India
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Nagpur, 440001, India
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Nashik, 422011, India
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Varanasi, 221005, India
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Bari, 70124, Italy
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Bergamo, 24125, Italy
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Milan, 20162, Italy
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Padua, 35128, Italy
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Parma, 43126, Italy
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Pavia, 27100, Italy
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Ravenna, 48100, Italy
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Roma, 00128, Italy
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Bunkyō City, 113-8677, Japan
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Fukuoka, 812-8582, Japan
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Kashiwa, 277-8577, Japan
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Kawasaki-shi, 216-8511, Japan
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Kōtoku, 135-8550, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Okayama, 700-8558, Japan
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Osaka, 541-8567, Japan
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Sagamihara-shi, 252-0375, Japan
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Sakai, 590-0197, Japan
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Sapporo, 001-0013, Japan
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Sendai, 980-0873, Japan
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Ube-shi, 755-0241, Japan
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Yokohama, 241-8515, Japan
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Amsterdam, 1081 HV, Netherlands
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Groningen, 9728 NT, Netherlands
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Nieuwegein, 3435 CM, Netherlands
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Tilburg, 5042AD, Netherlands
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Lublin, 20-090, Poland
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Poznan, 60-569, Poland
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Przemyśl, 37-700, Poland
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Radom, 26-600, Poland
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Warsaw, 01-138, Poland
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Warsaw, 02-781, Poland
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Banská Bystrica, 97517, Slovakia
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Bratislava, 82606, Slovakia
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Bratislava, 833 01, Slovakia
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Košice, 041 91, Slovakia
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Trnava, 917 75, Slovakia
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eManzimtoti, 4126, South Africa
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George, 6529, South Africa
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Johannesburg, 2193, South Africa
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Johannesburg, 2196, South Africa
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Pietermaritzburg, 3245, South Africa
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Pretoria, 0002, South Africa
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Rondebosch, 7700, South Africa
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Soweto, 2013, South Africa
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Cheongju-si, 28644, South Korea
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Daegu, 42601, South Korea
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Incheon, 21565, South Korea
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Jinju, 52727, South Korea
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Seoul, 03080, South Korea
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Seoul, 06351, South Korea
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Seoul, 07061, South Korea
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Suwon, 16247, South Korea
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Suwon, 16499, South Korea
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Alicante, 03010, Spain
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Barcelona, 08003, Spain
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Barcelona, 08025, Spain
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Bilbao (Vizcaya), 48013, Spain
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Madrid, 28040, Spain
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Málaga, 29011, Spain
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Palma, 07198, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 833, Taiwan
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New Taipei City, 220, Taiwan
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Tainan, 70403, Taiwan
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Tainan, 73657, Taiwan
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Taipei, 100, Taiwan
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Taipei, 112, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan District, 33305, Taiwan
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Yunlin, 640, Taiwan
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Bangkok, 10700, Thailand
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Dusit, 10300, Thailand
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Lampang, 52000, Thailand
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Muang, 50200, Thailand
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Songkhla, 90110, Thailand
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Ankara, 6500, Turkey (Türkiye)
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Antalya, 07059, Turkey (Türkiye)
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Çankaya, 06680, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Fatih-Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Pamukkale, 20070, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Blackpool, FY3 8NR, United Kingdom
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Bury St Edmunds, IP332QZ, United Kingdom
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Colchester, CO4 5JL, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW10 9NH, United Kingdom
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London, SW170QT, United Kingdom
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Truro, TR1 3LJ, United Kingdom

Conditions

Explore the condition pages connected to this study.

METASTATIC NON-SMALL CELL LUNG CANCER