New hope for tough lung cancer: can two drugs beat one?

NCT ID NCT06211036

Summary

This study is for people with extensive-stage small-cell lung cancer who have already completed their first round of chemotherapy and immunotherapy (durvalumab) without their cancer getting worse. It aims to see if adding a new drug called tarlatamab to their ongoing durvalumab treatment helps them live longer and keeps the cancer under control better than continuing with durvalumab alone. About 563 people will be randomly assigned to receive either the combination or just durvalumab.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Affiliated Cancer Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830054, China

  • Affiliated Hospital of Guilin Medical University

    Guilin, Guangxi, 541001, China

  • Aichi Cancer Center

    Nagoya, Aichi-ken, 464-8681, Japan

  • Algemeen Ziekenhuis Maria Middelares

    Ghent, 9000, Belgium

  • Allegheny Health Network

    Pittsburgh, Pennsylvania, 15212, United States

  • Allina Health System dba Allina Health Cancer Institute

    Saint Paul, Minnesota, 55102, United States

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asklepios Fachkliniken Muenchen Gauting

    Gauting, 82130, Germany

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Attikon University Hospital

    Athens, 12462, Greece

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Azorg Campus Aalst - Moorselbaan

    Aalst, 9300, Belgium

  • Bagcilar Medipol Mega Universite Hastanesi

    Istanbul, 34214, Turkey (Türkiye)

  • Baptist Cancer Center Memphis Thoracic

    Memphis, Tennessee, 38120, United States

  • Beaumont Hospital

    Dublin, 9, Ireland

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality, 100142, China

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Beijing Chaoyang Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100020, China

  • CHU de Quebec Hopital de l Enfant Jesus

    Québec, Quebec, G1R 2J6, Canada

  • Cancer Research South Australia

    Adelaide, South Australia, 5000, Australia

  • Cancer and Hematology Centers of Western Michigan

    Grand Rapids, Michigan, 49503, United States

  • Cangzhou Peoples Hospital

    Cangzhou, Hebei, 061011, China

  • Cenantron Centro Avançado de Tratamento Oncologico Ltda

    Belo Horizonte, Minas Gerais, 30130-090, Brazil

  • Centre Hospitalier - Le Mans

    Le Mans, 72000, France

  • Centre Hospitalier Intercommunal de Creteil

    Créteil, 94010, France

  • Centre Hospitalier Regional Universitaire de Brest - Hopital Morvan

    Brest, 29200, France

  • Centre Hospitalier Universitaire Nord

    Marseille, 13915, France

  • Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec

    Saint-Herblain, 44800, France

  • Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil

    Strasbourg, 67091, France

  • Centre Hospitalier Universitaire de Toulouse - Hopital Larrey

    Toulouse, 31059, France

  • Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne

    Yvoir, 5530, Belgium

  • Centre Leon Berard

    Lyon, 69008, France

  • Centres Hospitaliers Universitaires - Helora - Hopital de Mons - Site Kennedy

    Mons, 7000, Belgium

  • Centro Ricerche Cliniche Di Verona Societa responsabilita limitata

    Verona, 37126, Italy

  • Chris OBrien Lifehouse

    Camperdown, New South Wales, 2050, Australia

  • Chungbuk National University Hospital

    Cheongju Chungbuk, 28644, South Korea

  • Clinica Universidad de Navarra

    Pamplona, Navarre, 31008, Spain

  • Clinique Teissier

    Valenciennes, 59300, France

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii

    Wroclaw, 53-439, Poland

  • Duke University

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Erasmus Medisch Centrum

    Rotterdam, 3015 GD, Netherlands

  • European Interbalkan Medical Center

    Thessaloniki, 57001, Greece

  • Exelsus Oncologia Clinica

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Olomouc

    Olomouc, 779 00, Czechia

  • Fakultni nemocnice v Motole

    Prague, 150 06, Czechia

  • Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz

    Székesfehérvár, 8000, Hungary

  • Franciscan Health Indianapolis

    Indianapolis, Indiana, 46237, United States

  • Fujian Cancer Hospital

    Fuzhou, Fujian, 350014, China

  • Fundacao Antonio Prudente AC Camargo Cancer Center

    São Paulo, São Paulo, 01509-900, Brazil

  • Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer

    La Rioja, F5300COE, Argentina

  • Fundacion Medica de Rio Negro y Neuquen

    Cipolletti, Río Negro Province, 8324, Argentina

  • Greenslopes Private Hospital

    Greenslopes, Queensland, 4120, Australia

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530201, China

  • Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz

    Győr, 9024, Hungary

  • Health Pharma Professional Research SA de CV

    Mexico City, Mexico City, 03100, Mexico

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450003, China

  • Henry Dunant Hospital Center

    Athens, 11526, Greece

  • Hopital Cochin

    Paris, 75014, France

  • Hospital Britanico de Buenos Aires

    CABA, Buenos Aires, C1280AEB, Argentina

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036, Spain

  • Hospital Cuf Descobertas

    Lisbon, 1998-018, Portugal

  • Hospital Cuf porto

    Porto, 4100-180, Portugal

  • Hospital Israelita Albert Einstein

    São Paulo, São Paulo, 05652-900, Brazil

  • Hospital Regional Universitario de Malaga

    Málaga, Andalusia, 29011, Spain

  • Hospital Sao Rafael-Idor

    Salvador, Estado de Bahia, 40170-110, Brazil

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009, Spain

  • Hospital Uopeccan

    Cascavel, Paraná, 85806-300, Brazil

  • Hospital da Luz, SA

    Lisbon, 1500-650, Portugal

  • Hospital de Clinicas de Ijui

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Hospital de Clinicas de Passo Fundo

    Passo Fundo, Rio Grande do Sul, 99010-260, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalonia, 08041, Spain

  • Hubei Cancer Hospital

    Wuhan, Hubei, 430070, China

  • Hyogo Cancer Center

    Akashi-shi, Hyōgo, 673-8558, Japan

  • IRCCS Istituto Oncologico Europeo

    Milan, 20141, Italy

  • IRCCS Istituto Tumori Giovanni Paolo II

    Bari, 70124, Italy

  • Infirmary Cancer Center

    Mobile, Alabama, 36607, United States

  • Inselspital Bern

    Bern, 3010, Switzerland

  • Institut Bergonie

    Bordeaux, 33000, France

  • Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Catalonia, 08908, Spain

  • Institut Jules Bordet

    Brussels, B-1070, Belgium

  • Institut regional du Cancer Montpellier

    Montpellier, 34298, France

  • Instituto Alexander Fleming

    Capital Federal, Buenos Aires, C1426ANZ, Argentina

  • Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca

    Cluj-Napoca, 400015, Romania

  • Instytut Gruzlicy i Chorob Pluc

    Warsaw, 01-138, Poland

  • Irmandade da Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90020-090, Brazil

  • Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi

    Izmir, 35150, Turkey (Türkiye)

  • Jiamusi Cancer Hospital

    Jiamusi, Heilongjiang, 154007, China

  • Jiangxi Cancer hospital

    Nanchang, Jiangxi, 330029, China

  • Jilin Cancer Hospital

    Changchun, Jilin, 130012, China

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center

    Yokohama, Kanagawa, 241-8515, Japan

  • Kansai Medical University Hospital

    Hirakata-shi, Osaka, 573-1191, Japan

  • Kantonsspital Sankt Gallen

    Sankt Gallen, 9007, Switzerland

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Kindai University Hospital

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Kliniken der Stadt Koeln gGmbH

    Cologne, 51109, Germany

  • Kurume University Hospital

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • Landeskrankenhaus Feldkirch

    Rankweil, 6830, Austria

  • Linyi Cancer Hospital

    Linyi, Shandong, 276000, China

  • London Health Sciences Centre

    London, Ontario, N6A 5W9, Canada

  • LungenClinic Grosshansdorf GmbH

    Großhansdorf, 22927, Germany

  • Maastricht Universitair Medisch Centrum

    Maastricht, 6229 HX, Netherlands

  • Matrai Gyogyintezet

    Gyöngyös, 3200, Hungary

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medical Park Seyhan Hastanesi

    Mersin, 33200, Turkey (Türkiye)

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Medizinische Universitaet Graz

    Graz, 8036, Austria

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Metropolitan General

    Athens, 15562, Greece

  • Metropolitan Hospital

    Athens, 18547, Greece

  • Monash Medical Centre

    Clayton, Victoria, 3168, Australia

  • Montefiore Medical Center - Bronx

    The Bronx, New York, 10461, United States

  • Nanjing Chest Hospital

    Nanjing, Jiangsu, 210029, China

  • National Cancer Center

    Goyang-si Gyeonggi-do, 10408, South Korea

  • National Cancer Center Hospital

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital

    Tainan, 70403, Taiwan

  • National Hospital Organization Hokkaido Cancer Center

    Sapporo, Hokkaido, 003-0804, Japan

  • National Hospital Organization Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Nebraska Cancer Specialists

    Omaha, Nebraska, 68130, United States

  • Nemocnice Agel Ostrava-Vitkovice as

    Ostrava-Vitkovice, 703 00, Czechia

  • Niigata Cancer Center Hospital

    Niigata, Niigata, 951-8566, Japan

  • Northeast Georgia Medical Center

    Gainesville, Georgia, 30501, United States

  • Odense Universitetshospital

    Odense C, 5000, Denmark

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Oncare

    Mexico City, Mexico City, 03810, Mexico

  • Oncoclinicas Rio de Janeiro S A

    Rio de Janeiro, 22250-905, Brazil

  • Oncology Associates of Oregon, PC

    Eugene, Oregon, 97401, United States

  • Oncology Hematology Associates

    Springfield, Missouri, 65807, United States

  • Oncology Hematology Care Incorporated

    Cincinnati, Ohio, 45242, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Orszagos Koranyi Pulmonologiai Intezet

    Budapest, 1121, Hungary

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Ospedale Regionale di Bellinzona e Vali

    Mendrisio, 6850, Switzerland

  • Our Lady of the Lake Cancer Institute

    Baton Rouge, Louisiana, 70808, United States

  • Prince of Wales Hospital, Chinese University of Hong Kong

    Shatin, New Territories, Hong Kong

  • Princess Margaret Hospital

    Kowloon, Hong Kong

  • Rabin Medical Center

    Petah Tikva, 4941492, Israel

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Reformatus Pulmonologiai Centrum

    Törökbálint, 2045, Hungary

  • Regionshospitalet Godstrup

    Herning, 7400, Denmark

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

  • Saint Lukes Hospital SA

    Thessaloniki, 55236, Greece

  • Saitama Medical University International Medical Center

    Hidaka-shi, Saitama, 350-1298, Japan

  • Sakarya Egitim ve Arastirma Hastanesi

    Sakarya, 54290, Turkey (Türkiye)

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Santa Casa de Misericordia de Passos

    Passos, Minas Gerais, 37904-020, Brazil

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Semmelweis Egyetem

    Budapest, 1083, Hungary

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Shanghai Chest Hospital

    Shanghai, Shanghai Municipality, 200030, China

  • Shanghai Pulmonary Hospital

    Shanghai, Shanghai Municipality, 200433, China

  • Shanxi Provincial Cancer Hospital

    Taiyuan, Shanxi, 030009, China

  • Shizuoka Cancer Center

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Sir Charles Gairdner Hospital

    Nedlands, Western Australia, 6009, Australia

  • Sotiria General Hospital

    Athens, 11527, Greece

  • Spitalul Municipal Ploiesti

    Ploieşti, 100337, Romania

  • Sun Yat-sen University Cancer Center

    Guangzhou, Guangdong, 510060, China

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Texas Oncology - Dallas Fort Worth

    Dallas, Texas, 75246, United States

  • The Affiliated Cancer Hospital of Shandong First Medical University

    Jinan, Shandong, 250117, China

  • The Affiliated Hospital of Inner Mongolia Medical University

    Hohhot, Inner Mongolia, 010010, China

  • The Cancer Institute Hospital of Japanese Foundation for Cancer Research

    Koto-ku, Tokyo, 135-8550, Japan

  • The First Affiliated Hospital Of Ningbo University

    Ningbo, Zhejiang, 315010, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, 325015, China

  • The First Affiliated Hospital of Xian Jiaotong University

    Xi’an, Shanxi, 710065, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450066, China

  • The Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • The Second Attached Hospital Of Fujian Medical University

    Quanzhou, Fujian, 362002, China

  • Tianjin Peoples Hospital

    Tianjin, Tianjin Municipality, 300121, China

  • US Oncology Research Investigational Products Center

    Dallas, Texas, 75246, United States

  • Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano

    Matosinhos Municipality, 4464-513, Portugal

  • Universitaetsklinikum Dresden

    Dresden, 01307, Germany

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Universitaetsklinikum Krems

    Krems, 3500, Austria

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97078, Germany

  • Universitaetsspital Basel

    Basel, 4052, Switzerland

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650, Belgium

  • Universitair Ziekenhuis Brussel

    Brussels, 1090, Belgium

  • Universite Catholique de Louvain Cliniques Universitaires Saint Luc

    Brussels, 1200, Belgium

  • University Cancer and Blood Center LLC

    Athens, Georgia, 30607, United States

  • University Hospital Muenster

    Münster, 48149, Germany

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Illinois Chicago

    Chicago, Illinois, 60612, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Southern California

    Los Angeles, California, 90033, United States

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-214, Poland

  • VM Medical Park Mersin Hastanesi

    Mersin, 33200, Turkey (Türkiye)

  • Virginia Commonwealth University Massey Cancer Center

    Richmond, Virginia, 23298, United States

  • Virginia Oncology Associates

    Newport News, Virginia, 23606, United States

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08, Czechia

  • Wakayama Medical University Hospital

    Wakayama, Wakayama, 641-8510, Japan

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 611135, China

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow

    Poznan, 60-569, Poland

  • Wollongong Hospital

    Wollongong, New South Wales, 2500, Australia

  • Xinqiao Hospital

    Chongqing, Chongqing Municipality, 400037, China

  • Xuzhou Central Hospital

    Xuzhou, Jiangsu, 221009, China

  • Yale New Haven Hospital

    New Haven, Connecticut, 06510, United States

  • Ziekenhuis Oost-Limburg

    Genk, 3600, Belgium

  • the First Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003, China

Conditions

Explore the condition pages connected to this study.