Major trial tests new drug combo to extend lives in aggressive lung cancer

NCT ID NCT03043872

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial tested whether adding one or two immunotherapy drugs (durvalumab and tremelimumab) to standard chemotherapy could help patients with extensive-stage small cell lung cancer live longer. Nearly 1,000 adults with this advanced cancer were randomly assigned to receive either the new drug combinations or standard chemotherapy alone. The main goal was to see if the new treatments improved overall survival.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SMALL CELL LUNG CARCINOMA EXTENSIVE DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Research Site

Birmingham, Alabama, 35235, United States
Research Site

Scottsdale, Arizona, 85259, United States
Research Site

Rogers, Arkansas, 72758, United States
Research Site

Santa Monica, California, 90404, United States
Research Site

New Haven, Connecticut, 06520, United States
Research Site

Athens, Georgia, 30607, United States
Research Site

Fort Wayne, Indiana, 46804, United States
Research Site

Muncie, Indiana, 47303, United States
Research Site

Leawood, Kansas, 66209, United States
Research Site

Wichita, Kansas, 67214, United States
Research Site

Paducah, Kentucky, 42003, United States
Research Site

Grand Rapids, Michigan, 49503, United States
Research Site

Mineola, New York, 11501, United States
Research Site

Cleveland, Ohio, 44106, United States
Research Site

Columbus, Ohio, 43219, United States
Research Site

Harrisburg, Pennsylvania, 17109, United States
Research Site

Sioux Falls, South Dakota, 57104, United States
Research Site

Nashville, Tennessee, 37203, United States
Research Site

Kennewick, Washington, 99336, United States
Research Site

Buenos Aires, C1118AAT, Argentina
Research Site

Ciudad de Buenos Aires, C1426, Argentina
Research Site

Mar del Plata, 7600, Argentina
Research Site

Rosario, 2000, Argentina
Research Site

San Miguel de Tucumán, T4000IAK, Argentina
Research Site

Linz, 4021, Austria
Research Site

Salzburg, 5020, Austria
Research Site

Vienna, 1140, Austria
Research Site

Vienna, 1210, Austria
Research Site

Barretos, 14784-400, Brazil
Research Site

Curitiba, 81520-060, Brazil
Research Site

Passo Fundo, 99010 260, Brazil
Research Site

Porto Alegre, 91350-200, Brazil
Research Site

Ribeirão Preto, 14048-900, Brazil
Research Site

Rio de Janeiro, 22793-080, Brazil
Research Site

Salvador, 41.950-610, Brazil
Research Site

Santo André, 09060-650, Brazil
Research Site

São José do Rio Preto, 15090-000, Brazil
Research Site

São Paulo, 03102-002, Brazil
Research Site

Panagyurishte, 4500, Bulgaria
Research Site

Plovdiv, 4000, Bulgaria
Research Site

Plovdiv, 4004, Bulgaria
Research Site

Sofia, 1330, Bulgaria
Research Site

Sofia, 1431, Bulgaria
Research Site

Sofia, 1618, Bulgaria
Research Site

Sofia, 1784, Bulgaria
Research Site

Varna, 9010, Bulgaria
Research Site

Beijing, 100142, China
Research Site

Beijing, 100730, China
Research Site

Beijing, 100853, China
Research Site

Bengbu, 233004, China
Research Site

Changchun, 130021, China
Research Site

Changsha, 410013, China
Research Site

Chengdu, 610041, China
Research Site

Chongqing, 400038, China
Research Site

Hangzhou, 310003, China
Research Site

Hangzhou, 310006, China
Research Site

Hangzhou, 310009, China
Research Site

Hefei, 230601, China
Research Site

Nanchang, 330006, China
Research Site

Nanjing, 210009, China
Research Site

Nanjing, 210029, China
Research Site

Shanghai, 200032, China
Research Site

Shanghai, 200433, China
Research Site

Shenyang, 110042, China
Research Site

Ürümqi, 830000, China
Research Site

Wenzhou, 325000, China
Research Site

Wuhan, 430022, China
Research Site

Wuhan, 430030, China
Research Site

Xi'an, 710038, China
Research Site

Xi'an, 710061, China
Research Site

Zhanjiang, 524001, China
Research Site

Zhengzhou, 450008, China
Research Site

Zhuhai, 519099, China
Research Site

Brno, 639 00, Czechia
Research Site

Olomouc, 775 21, Czechia
Research Site

Ostrava - Vitkovice, 703 84, Czechia
Research Site

Prague, 128 08, Czechia
Research Site

Prague, 140 59, Czechia
Research Site

Prague, CZ-150 18, Czechia
Research Site

Avignon, 84918, France
Research Site

Brest, 29609, France
Research Site

Créteil, 94010, France
Research Site

La Tronche, 38043, France
Research Site

Pierre-Bénite, 69310, France
Research Site

Rennes, 35033, France
Research Site

Aachen, 52074, Germany
Research Site

Berlin, 13125, Germany
Research Site

Gauting, 82131, Germany
Research Site

Gera, 07548, Germany
Research Site

Hamburg, 20251, Germany
Research Site

Heidelberg, 69126, Germany
Research Site

Mainz, 55131, Germany
Research Site

Regensburg, 93053, Germany
Research Site

Budapest, 1083, Hungary
Research Site

Budapest, 1106, Hungary
Research Site

Budapest, 1121, Hungary
Research Site

Budapest, 1134, Hungary
Research Site

Deszk, 6772, Hungary
Research Site

Gyula, 5700, Hungary
Research Site

Kaposvár, 7400, Hungary
Research Site

Kecskemét, 6000, Hungary
Research Site

Miskolc, 3529, Hungary
Research Site

Pécs, 7624, Hungary
Research Site

Székesfehérvár, 8000, Hungary
Research Site

Jerusalem, 91031, Israel
Research Site

Kfar Saba, 95847, Israel
Research Site

Petah Tikva, 49100, Israel
Research Site

Ramat Gan, 5265601, Israel
Research Site

Bergamo, 24127, Italy
Research Site

Meldola, 47014, Italy
Research Site

Milan, 20133, Italy
Research Site

Palermo, 90146, Italy
Research Site

Roma, 00100, Italy
Research Site

Terni, 05100, Italy
Research Site

Chūōku, 104-0045, Japan
Research Site

Fukuoka, 812-8582, Japan
Research Site

Fukushima, 960-1295, Japan
Research Site

Himeji-shi, 670-8520, Japan
Research Site

Iwakuni-shi, 740-8510, Japan
Research Site

Kashiwa, 227-8577, Japan
Research Site

Kōtoku, 135-8550, Japan
Research Site

Kurume-shi, 830-0011, Japan
Research Site

Kyoto, 606-8507, Japan
Research Site

Matsuyama, 791-0280, Japan
Research Site

Nagoya, 464-8681, Japan
Research Site

Nagoya, 466-8560, Japan
Research Site

Okayama, 700-8558, Japan
Research Site

Sakaishi, 591-8555, Japan
Research Site

Sayama, 589-8511, Japan
Research Site

Tokushima, 770-8503, Japan
Research Site

Ube-shi, 755-0241, Japan
Research Site

Yokohama, 236-0004, Japan
Research Site

Yokohama, 241-8515, Japan
Research Site

Amsterdam, 1066 CX, Netherlands
Research Site

Arnhem, 6815 AD, Netherlands
Research Site

Groningen, 9713 GZ, Netherlands
Research Site

Hengelo, 7555 DL, Netherlands
Research Site

Maastricht, 6202 AZ, Netherlands
Research Site

Rotterdam, 3015 GD, Netherlands
Research Site

Bialystok, 15-027, Poland
Research Site

Bialystok, 15-540, Poland
Research Site

Lublin, 20-954, Poland
Research Site

Olsztyn, 10-357, Poland
Research Site

Warsaw, 02-781, Poland
Research Site

Cluj-Napoca, 400015, Romania
Research Site

Floreşti, 407280, Romania
Research Site

Suceava, 720237, Romania
Research Site

Moscow, 105229, Russia
Research Site

Omsk, 644013, Russia
Research Site

Rostov-on-Don, 344037, Russia
Research Site

Saint Petersburg, 194291, Russia
Research Site

Saint Petersburg, 195271, Russia
Research Site

Saint Petersburg, 196603, Russia
Research Site

Saint Petersburg, 197758, Russia
Research Site

Ufa, 450054, Russia
Research Site

Banská Bystrica, 97517, Slovakia
Research Site

Bardejov, 085 01, Slovakia
Research Site

Bratislava, 82606, Slovakia
Research Site

Bratislava, 833 01, Slovakia
Research Site

Košice, 041 91, Slovakia
Research Site

Nové Zámky, 940 01, Slovakia
Research Site

Trnava, 91708, Slovakia
Research Site

Changwon, 51353, South Korea
Research Site

Cheongju-si, 28644, South Korea
Research Site

Daegu, 42415, South Korea
Research Site

Incheon, 21565, South Korea
Research Site

Jinju, 660-702, South Korea
Research Site

Seongnam-si, 13620, South Korea
Research Site

Seongnam-si, 463-712, South Korea
Research Site

Seoul, 05505, South Korea
Research Site

Seoul, 110746, South Korea
Research Site

A Coruña, 15006, Spain
Research Site

Badajoz, 06008, Spain
Research Site

Badalona, 08916, Spain
Research Site

Barcelona, 08041, Spain
Research Site

Madrid, 08035, Spain
Research Site

Madrid, 28040, Spain
Research Site

Madrid, 28041, Spain
Research Site

Santander, 39008, Spain
Research Site

Valencia, 46010, Spain
Research Site

Zaragoza, 50009, Spain
Research Site

Changhua, 50006, Taiwan
Research Site

Kaohsiung City, 82445, Taiwan
Research Site

Kaohsiung City, 83301, Taiwan
Research Site

Taichung, 40447, Taiwan
Research Site

Taichung, 40705, Taiwan
Research Site

Tainan, 704, Taiwan
Research Site

Tainan, 736, Taiwan
Research Site

Taipei, 11217, Taiwan
Research Site

Taipei, 235, Taiwan
Research Site

Ankara, 06230, Turkey (Türkiye)
Research Site

Ankara, Turkey (Türkiye)
Research Site

Edirne, 22030, Turkey (Türkiye)
Research Site

Istanbul, 32098, Turkey (Türkiye)
Research Site

Izmir, 35100, Turkey (Türkiye)
Research Site

Izmir, 35620, Turkey (Türkiye)
Research Site

Dnipro, 49102, Ukraine
Research Site

Ivano-Frankivsk, 76018, Ukraine
Research Site

Kirovohrad, 25006, Ukraine
Research Site

Kryvyi Rih, 50048, Ukraine
Research Site

Kyiv, 03022, Ukraine
Research Site

Kyiv, 03115, Ukraine
Research Site

Lviv, 79031, Ukraine
Research Site

Odesa, 65055, Ukraine
Research Site

Sumy, 40022, Ukraine
Research Site

Vinnytsia, 21029, Ukraine
Research Site

Zaporizhzhia, 69040, Ukraine

Conditions

Explore the condition pages connected to this study.

SMALL CELL LUNG CARCINOMA EXTENSIVE DISEASE