New combo therapy aims to keep lung cancer at bay after initial treatment

NCT ID NCT04475939

Ongoing Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding the drug niraparib to standard pembrolizumab maintenance therapy helps people with advanced non-small cell lung cancer live longer without their cancer getting worse. It involves 666 adults whose cancer stabilized or shrank after initial chemotherapy. Participants are randomly assigned to receive either the two-drug combination or pembrolizumab with a placebo pill to see which approach better controls the disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

GSK Investigational Site

Fullerton, California, 92835, United States
GSK Investigational Site

Los Angeles, California, 90017, United States
GSK Investigational Site

Lone Tree, Colorado, 80128, United States
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Norwich, Connecticut, 06360, United States
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Tallahassee, Florida, 32003, United States
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Atlanta, Georgia, 30322, United States
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Newnan, Georgia, 30265, United States
GSK Investigational Site

Niles, Illinois, 60714, United States
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Iowa City, Iowa, 52242, United States
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Worcester, Massachusetts, 01655, United States
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Mineola, New York, 10016, United States
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New York, New York, 10016-4744, United States
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Charlotte, North Carolina, 28207, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37203, United States
GSK Investigational Site

Dallas, Texas, 75246, United States
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San Antonio, Texas, 78217, United States
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Sherman, Texas, 75090, United States
GSK Investigational Site

Sugar Land, Texas, 77479, United States
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Waco, Texas, 76712, United States
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Fairfax, Virginia, 22031, United States
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Buenos Aires, C1125ABD, Argentina
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Buenos Aires, C1426ABP, Argentina
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Cipoletti Rio Negro, R8324CVE, Argentina
GSK Investigational Site

Ciudad Autonoma de Buenos Aire, C1012AAR, Argentina
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Ciudad Autonoma de Buenos Aire, C1426AGE, Argentina
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Córdoba, X5004FHP, Argentina
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Florida, 1602, Argentina
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La Plata, 1900, Argentina
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Rosario, S2000DSV, Argentina
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Blacktown, New South Wales, 2148, Australia
GSK Investigational Site

Hobart, Tasmania, 7000, Australia
GSK Investigational Site

Ballarat, Victoria, 3350, Australia
GSK Investigational Site

Heidelberg, Victoria, 3084, Australia
GSK Investigational Site

Brussels, 1200, Belgium
GSK Investigational Site

Edegem, 2650, Belgium
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Leuven, 3000, Belgium
GSK Investigational Site

Roeselare, 8800, Belgium
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Belo Horizonte, 30110-022, Brazil
GSK Investigational Site

Cachoeiro de Itapemirim, 29308-014, Brazil
GSK Investigational Site

Curitiba, 80040-170, Brazil
GSK Investigational Site

Porto Alegre, 90610-000, Brazil
GSK Investigational Site

Rio de Janeiro, 22250-905, Brazil
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São Paulo, 01308-901, Brazil
GSK Investigational Site

São Paulo, 01509-010, Brazil
GSK Investigational Site

Uberlândia, 38408-150, Brazil
GSK Investigational Site

Panagyurishte, 4500, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4004, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1632, Bulgaria
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Santiago, 7500653, Chile
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Temuco, 5360000, Chile
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Bogotá, 5600520, Colombia
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Montería, 230018, Colombia
GSK Investigational Site

Brest, 29609, France
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Créteil, 94010, France
GSK Investigational Site

Grenoble, 38043, France
GSK Investigational Site

Lille, 59037, France
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Paris, 75014, France
GSK Investigational Site

Paris, 75018, France
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Rennes, 35033, France
GSK Investigational Site

Saint-Herblain, 44093, France
GSK Investigational Site

Strasbourg, 67200, France
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Toulon, 83056, France
GSK Investigational Site

Toulouse, 31059, France
GSK Investigational Site

Berlin, 13125, Germany
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Bonn, 53113, Germany
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Essen, 45147, Germany
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Frankfurt, 60488, Germany
GSK Investigational Site

Gauting, 82131, Germany
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Großhansdorf, 22927, Germany
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Halle, 06120, Germany
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Hamburg, 20251, Germany
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Hanover, 30459, Germany
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Heidelberg, 69126, Germany
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Hemer, 58675, Germany
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Jena, 07747, Germany
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München, 80336, Germany
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München, 81925, Germany
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Stuttgart, 70376, Germany
GSK Investigational Site

Velbert, 42551, Germany
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Athens, 115 27, Greece
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Athens, 11526, Greece
GSK Investigational Site

Athens, 11528, Greece
GSK Investigational Site

Athens, 12462, Greece
GSK Investigational Site

Athens, 15125, Greece
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Athens, 15562, Greece
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Athens, 185 37, Greece
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Heraklion Crete, 71110, Greece
GSK Investigational Site

Larissa, 41110, Greece
GSK Investigational Site

Neo Faliro, 185 47, Greece
GSK Investigational Site

Pátrai, 26500, Greece
GSK Investigational Site

Pylaia Thessaloniki, 57001, Greece
GSK Investigational Site

Rio Patras, 26500, Greece
GSK Investigational Site

Thessaloniki, 54007, Greece
GSK Investigational Site

Thessaloniki, 54622, Greece
GSK Investigational Site

Thessaloniki, 54645, Greece
GSK Investigational Site

Thessaloniki, 57010, Greece
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Budapest, 1083, Hungary
GSK Investigational Site

Budapest, H-1122, Hungary
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Gyöngyös, 3200, Hungary
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Tatabánya, 2800, Hungary
GSK Investigational Site

Törökbálint, 2045, Hungary
GSK Investigational Site

Cork, T12 DFK4, Ireland
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Dublin, 8, Ireland
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Avellino, 83100, Italy
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Aviano PN, 33081, Italy
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Bari, 70124, Italy
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Catania, 95123, Italy
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Florence, 50134, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Monza, 20900, Italy
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Napoli, 80131, Italy
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Orbassano to, 10043, Italy
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Pisa, 56124, Italy
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Roma, 00168, Italy
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Verona, 37045, Italy
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Mexico City, 03100, Mexico
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Mexico City, 06700, Mexico
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Mexico City, CP 14080, Mexico
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Monterrey, 64460, Mexico
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Puebla Puebla, 72560, Mexico
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's-Hertogenbosch, 5223 GZ, Netherlands
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Amersfoort, 3813 TZ, Netherlands
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Amsterdam, 1066 CX, Netherlands
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Enschede, 7512 KZ, Netherlands
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Maastricht, 6229 HX, Netherlands
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Utrecht, 3543 AZ, Netherlands
GSK Investigational Site

Zwolle, 8025 AB, Netherlands
GSK Investigational Site

Drammen, N-3004, Norway
GSK Investigational Site

Lrenskog, 1470, Norway
GSK Investigational Site

Oslo, N-0450, Norway
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Lima, Lima 34, Peru
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Bialystok, 15-540, Poland
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Lodz, 90-338, Poland
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Olsztyn, 10-357, Poland
GSK Investigational Site

Bucharest, 011654, Romania
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Bucharest, 022328, Romania
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Cluj-Napoca, 400015, Romania
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Craiova, 200542, Romania
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Iași, 700483, Romania
GSK Investigational Site

Satu Mare, 440055, Romania
GSK Investigational Site

Timișoara, 300239, Romania
GSK Investigational Site

Moscow, 105 229, Russia
GSK Investigational Site

Moscow, 121309, Russia
GSK Investigational Site

Nizhny Novgorod, 603081, Russia
GSK Investigational Site

Omsk, 644013, Russia
GSK Investigational Site

Saint Petersburg, 197022, Russia
GSK Investigational Site

Saint Petersburg, 197758, Russia
GSK Investigational Site

Seongnam-si, 463-712, South Korea
GSK Investigational Site

Seongnam-si Gyeonggi-do, 13620, South Korea
GSK Investigational Site

Seoul, 05505, South Korea
GSK Investigational Site

Seoul, 08308, South Korea
GSK Investigational Site

Suwon Kyunggi-do, 443-721, South Korea
GSK Investigational Site

A Coruña, 15006, Spain
GSK Investigational Site

Barcelona, 08025, Spain
GSK Investigational Site

Barcelona, 08035, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Córdoba, 140044, Spain
GSK Investigational Site

Girona, 17007, Spain
GSK Investigational Site

Las Palmas de Gran Canar, 35016, Spain
GSK Investigational Site

Madrid, 28009, Spain
GSK Investigational Site

Madrid, 28027, Spain
GSK Investigational Site

Madrid, 28041, Spain
GSK Investigational Site

Madrid, 28046, Spain
GSK Investigational Site

Madrid, 28050, Spain
GSK Investigational Site

Madrid, 28222, Spain
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Málaga, 29010, Spain
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PamplonaNavarra, 31008, Spain
GSK Investigational Site

Santander, 39008, Spain
GSK Investigational Site

Zaragoza, 50009, Spain
GSK Investigational Site

Gävle, SE-801 87, Sweden
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Stockholm, SE-171 76, Sweden
GSK Investigational Site

Uppsala, SE-751 85, Sweden
GSK Investigational Site

Lausanne, 1011, Switzerland
GSK Investigational Site

Ankara, 06010, Turkey (Türkiye)
GSK Investigational Site

Ankara, 06100, Turkey (Türkiye)
GSK Investigational Site

Ankara, 06520, Turkey (Türkiye)
GSK Investigational Site

Edirne, 22030, Turkey (Türkiye)
GSK Investigational Site

Istanbul, 34662, Turkey (Türkiye)
GSK Investigational Site

Bournemouth, BH7 7DW, United Kingdom
GSK Investigational Site

Dundee, DD1 9SY, United Kingdom
GSK Investigational Site

Middlesex, HA6 2RN, United Kingdom
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Oxford, OX3 7LJ, United Kingdom
GSK Investigational Site

Wrexham, LL13 7TD, United Kingdom

Conditions

Explore the condition pages connected to this study.

LUNG CANCER (NON-SMALL CELL)