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Breakthrough drug doubles time before lung cancer worsens

NCT ID NCT02296125

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated Apr 20, 2026 · Updated 18 times

Summary

This large study tested whether a new targeted drug (osimertinib) works better than standard treatments for people with advanced lung cancer that has specific genetic mutations. The trial involved 674 patients whose cancer had spread and couldn't be cured with surgery or radiation. Researchers compared how long patients' cancer stayed under control without getting worse between the new drug and existing treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Anaheim, California, 92801, United States

  • Research Site

    Santa Rosa, California, 95403, United States

  • Research Site

    West Hills, California, 91307, United States

  • Research Site

    Tampa, Florida, 33612, United States

  • Research Site

    Atlanta, Georgia, 30318, United States

  • Research Site

    Atlanta, Georgia, 30322, United States

  • Research Site

    Marietta, Georgia, 30060, United States

  • Research Site

    Louisville, Kentucky, 40202, United States

  • Research Site

    Bethesda, Maryland, 20817, United States

  • Research Site

    Boston, Massachusetts, 02215, United States

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    Minneapolis, Minnesota, 55407, United States

  • Research Site

    Lebanon, New Hampshire, 03756, United States

  • Research Site

    Salisbury, North Carolina, 28144, United States

  • Research Site

    Burlington, Vermont, 05401, United States

  • Research Site

    Camperdown, 2050, Australia

  • Research Site

    Chermside, 4032, Australia

  • Research Site

    Clayton, 3168, Australia

  • Research Site

    Heidelberg, 3084, Australia

  • Research Site

    Kogarah, 2217, Australia

  • Research Site

    Nedlands, 6009, Australia

  • Research Site

    Woolloongabba, 4102, Australia

  • Research Site

    Leuven, 3000, Belgium

  • Research Site

    Liège, 4000, Belgium

  • Research Site

    Roeselare, 8800, Belgium

  • Research Site

    Porto Alegre, 90610-000, Brazil

  • Research Site

    Sofia, 1330, Bulgaria

  • Research Site

    Edmonton, Alberta, T6G 1Z2, Canada

  • Research Site

    Hamilton, Ontario, L8V 5C2, Canada

  • Research Site

    Ottawa, Ontario, K1H 8L6, Canada

  • Research Site

    Toronto, Ontario, M4N 3M5, Canada

  • Research Site

    Toronto, Ontario, M5G 1X5, Canada

  • Research Site

    Toronto, Ontario, M5G 2M9, Canada

  • Research Site

    Beijing, 100071, China

  • Research Site

    Beijing, 100853, China

  • Research Site

    Changchun, 130012, China

  • Research Site

    Changchun, 130021, China

  • Research Site

    Chongqing, 400037, China

  • Research Site

    Chongqing, 400038, China

  • Research Site

    Chongqing, 400042, China

  • Research Site

    Fuzhou, 350025, China

  • Research Site

    Guangzhou, 510080, China

  • Research Site

    Hangzhou, 310022, China

  • Research Site

    Nanjing, 210029, China

  • Research Site

    Nanning, 530021, China

  • Research Site

    Shanghai, 200433, China

  • Research Site

    Shenyang, 110001, China

  • Research Site

    Suzhou, 215006, China

  • Research Site

    Ürümqi, 830000, China

  • Research Site

    Wuhan, 430071, China

  • Research Site

    Xi'an, 710038, China

  • Research Site

    Xi'an, 710061, China

  • Research Site

    Yangzhou, 225001, China

  • Research Site

    Ostrava, 708 52, Czechia

  • Research Site

    Caen, F-14033, France

  • Research Site

    Créteil, 94010, France

  • Research Site

    Lyon, 69373, France

  • Research Site

    Nantes, 44202, France

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    Toulon Naval, 83800, France

  • Research Site

    Villejuif, 94805, France

  • Research Site

    Bad Berka, 99437, Germany

  • Research Site

    Berlin, 13125, Germany

  • Research Site

    Gauting, 82131, Germany

  • Research Site

    Halle, 06120, Germany

  • Research Site

    Heidelberg, 69126, Germany

  • Research Site

    Karlsruhe, 76137, Germany

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    Lübeck, 23538, Germany

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    München, 81925, Germany

  • Research Site

    Villingen-Schwenningen, 78052, Germany

  • Research Site

    Farkasgyepü, 8582, Hungary

  • Research Site

    Gyöngyös - Mátraháza, 3200, Hungary

  • Research Site

    Miskolc, 3529, Hungary

  • Research Site

    Székesfehérvár, 8000, Hungary

  • Research Site

    Tatabánya, 2800, Hungary

  • Research Site

    Zalaegerszeg, 8900, Hungary

  • Research Site

    Haifa, 31999, Israel

  • Research Site

    Kfar Saba, 4428164, Israel

  • Research Site

    Petah Tikva, 49100, Israel

  • Research Site

    Tel Litwinsky, 52621, Israel

  • Research Site

    Cremona, 26100, Italy

  • Research Site

    Lecce, 73100, Italy

  • Research Site

    Lecco, 23900, Italy

  • Research Site

    Orbassano, 10043, Italy

  • Research Site

    Parma, 43126, Italy

  • Research Site

    Roma, 00144, Italy

  • Research Site

    Sondrio, 23100, Italy

  • Research Site

    Terni, 05100, Italy

  • Research Site

    Chūōku, 104-0045, Japan

  • Research Site

    Fukuoka, 812-8582, Japan

  • Research Site

    Hirakata-shi, 573-1191, Japan

  • Research Site

    Kanazawa, 920-8641, Japan

  • Research Site

    Kashiwa, 277-8577, Japan

  • Research Site

    Kobe, 650-0047, Japan

  • Research Site

    Matsuyama, 791-0280, Japan

  • Research Site

    Natori-shi, 981-1293, Japan

  • Research Site

    Osaka, 541-8567, Japan

  • Research Site

    Osakasayama-shi, 589-8511, Japan

  • Research Site

    Sagamihara-shi, 252-0375, Japan

  • Research Site

    Sakaishi, 591-8555, Japan

  • Research Site

    Sendai, 980-0873, Japan

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    Sunto-gun, 411-8777, Japan

  • Research Site

    Yokohama, 232-0024, Japan

  • Research Site

    Yokohama, 236-0051, Japan

  • Research Site

    Yokohama, 240-8555, Japan

  • Research Site

    Yokohama, 241-8515, Japan

  • Research Site

    Kuala Lumpur, 59100, Malaysia

  • Research Site

    Kuantan, 25100, Malaysia

  • Research Site

    Kuching, 93586, Malaysia

  • Research Site

    Cebu, 6000, Philippines

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    Manila, 1000, Philippines

  • Research Site

    Quezon City, 1100, Philippines

  • Research Site

    Brzozoów, 36-200, Poland

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    Otwock, 05-400, Poland

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    Poznan, 60-569, Poland

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    Szczecin, 70-891, Poland

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    Warsaw, 02-781, Poland

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    Amadora, 2720-276, Portugal

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    Lisbon, 1769-001, Portugal

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    Porto, 4200-072, Portugal

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    Vila Nova de Gaia, 4434-502, Portugal

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    Bucharest, 022328, Romania

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    Bucharest, 050098, Romania

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    Craiova, 200347, Romania

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    Saint Petersburg, 197022, Russia

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    Saint Petersburg, 197758, Russia

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    Saint Petersburg, 198255, Russia

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    Cheongju-si, 28644, South Korea

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    Incheon, 405-760, South Korea

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    Seongnam-si, 13620, South Korea

  • Research Site

    Seoul, 02841, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 06591, South Korea

  • Research Site

    Seoul, 5030, South Korea

  • Research Site

    A Coruña, 15006, Spain

  • Research Site

    Barcelona, 08041, Spain

  • Research Site

    Barcelona, 08221, Spain

  • Research Site

    Barcelona, 08907, Spain

  • Research Site

    Lleida, 25198, Spain

  • Research Site

    Lugo, 27003, Spain

  • Research Site

    Madrid, 28040, Spain

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    Málaga, 29010, Spain

  • Research Site

    Seville, 41014, Spain

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    Zaragoza, 50009, Spain

  • Research Site

    Linköping, 581 85, Sweden

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    Lucerne, 6000, Switzerland

  • Research Site

    Winterthur, 8401, Switzerland

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    Zurich, 8091, Switzerland

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    Kaohsiung City, 833, Taiwan

  • Research Site

    Taichung, 402, Taiwan

  • Research Site

    Tainan, 704, Taiwan

  • Research Site

    Tainan, 73657, Taiwan

  • Research Site

    Taoyuan, 333, Taiwan

  • Research Site

    Bangkok, 10330, Thailand

  • Research Site

    Bangkok, 10400, Thailand

  • Research Site

    Bangkok, 10700, Thailand

  • Research Site

    Hat Yai, 90110, Thailand

  • Research Site

    Muang, 50200, Thailand

  • Research Site

    Ankara, 6500, Turkey (Türkiye)

  • Research Site

    Istanbul, 34069, Turkey (Türkiye)

  • Research Site

    Izmir, 35100, Turkey (Türkiye)

  • Research Site

    Dnipro, 49102, Ukraine

  • Research Site

    Kryvyi Rih, 50048, Ukraine

  • Research Site

    Lviv, 79031, Ukraine

  • Research Site

    Sumy, 40022, Ukraine

  • Research Site

    Edinburgh, EH4 2XU, United Kingdom

  • Research Site

    London, NW1 2BU, United Kingdom

  • Research Site

    Maidstone, ME16 9QQ, United Kingdom

  • Research Site

    Withington, M20 4BX, United Kingdom

  • Research Site

    Hanoi, 100000, Vietnam

  • Research Site

    Hanoi, 10000, Vietnam

  • Research Site

    Ho Chi Minh City, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED OR METASTATIC EGFR SENSITISING MUTATION POSITIVE NON SMALL CELL LUNG CANCER