New combo attack on tough lung cancers shows promise

NCT ID NCT02917993

Summary

This study tested whether adding a new drug called itacitinib to an existing lung cancer medication (osimertinib) is safe and effective. It involved 59 adults with advanced non-small cell lung cancer that had specific genetic changes (EGFR and T790M mutations) and had stopped responding to prior treatments. The main goals were to find a safe dose and see if the combination could shrink tumors.

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Contacts and locations

Locations

  • Antiga Guarderia-Servei d'Oncologia Hospital Vall d'Hebron. P.Vall Hebron 119-129

    Barcelona, 08035, Spain

  • Asan Medical Center Department of Oncology, 88, Olympic-ro 43-gil

    Seoul, Songpa-gu, 05505, South Korea

  • Cleveland Clinic, 9500 Euclid Avenue, G Building

    Cleveland, Ohio, 44195, United States

  • Dana-Farber Cancer Institute, 450 Brookline Avenue

    Boston, Massachusetts, 02215, United States

  • Earle A. Chiles Research Institute Providence Cancer Center, 4805 NE Glisan Street, 2N35

    Portland, Oregon, 97213, United States

  • Georgetown University Hospital, 3800 Reservoir Rd, NW

    Washington D.C., District of Columbia, 20007, United States

  • Henry Ford Health System, 2799 W Grand Blvd.

    Detroit, Michigan, 48202, United States

  • Hospital Clinico Universitario Valencia Avenida Blasco Ibáñez 17 -8º

    Valencia, 46010, Spain

  • Hospital Ramón y Cajal Ctra. Colmenar Viejo Km. 9,1 Planta (-)2 Dcha Oficina de Ensayos Clínicos Servicio de Oncología Médica

    Madrid, 28034, Spain

  • Huntsman Cancer Institute, 2000 Circle of Hope Drive

    Salt Lake City, Utah, 84112, United States

  • Innovative Clinical Research Institute, 15111 Whittier Blvd., Suite 216

    Whittier, California, 90603, United States

  • Karmanos Cancer Institute, 4100 John R. street mail Code HW04HO

    Detroit, Michigan, 48202, United States

  • Lynn Cancer Center, 701 NW 13th Street, Floor 2

    Boca Raton, Florida, 33486, United States

  • NYU Langone Medical Center, 160 East 34th Street, Floor 8

    New York, New York, 10016, United States

  • National Taiwan University Hospital, 7 Zhongshan South Road

    Taipei, Zhongzheng District, 10002, Taiwan

  • Rocky Mountain Cancer Center, 1800 Williams Street, Suite 200

    Denver, Colorado, 80124, United States

  • Severance Hospital, Yonsei University Health System 50-1 Yonsei-ro

    Seoul, Seodaemun-gu, 03722, South Korea

  • St. Luke's University Health Network, 701 Ostrum Street, Suite 403

    Fountain Hill, Pennsylvania, 18015, United States

  • Stony Brook University Medical Center, 3 Edmund D. Pellegrino Road

    Stony Brook, New York, 11794, United States

  • Taipei Veterans General Hospital, No.201 Sec. 2 Shipai Rd l

    Taipei, Beitou District, 11217, Taiwan

  • Texas Oncology - San Antonio Medical, 5206 Research Drive

    San Antonio, Texas, 78240, United States

  • Texas Oncology - South Austin, 901 West 38th Street, Suite 200

    Austin, Texas, 78705, United States

  • Texas Oncology-Tyler, 910 E Houston Street, Suite 100

    Tyler, Texas, 75702, United States

  • The catholic University of Korea, Seoul St. Mary's hospital, 222 Banpo-daero

    Seoul, Seocho-gu, 06591, South Korea

  • Thomas Jefferson University, 111 S. 11th Street

    Philadelphia, Pennsylvania, 19107, United States

  • US Oncology-Virginia Cancer Specialists, PC, 8503 Arlington Blvd., Suite 400

    Fairfax, Virginia, 22031, United States

  • University California San Francisco Thoracic Surgery and Oncology Clinic, 1600 Divisadero Street, Floor 4

    San Francisco, California, 94115, United States

  • University of California San Diego, 3855 Health Sciences Drive, Mc 0987

    La Jolla, California, 92093, United States

  • University of Texas -MD Anderson Cancer Center, 1515 Holcombe Blvd.

    Houston, Texas, 77030, United States

  • Valley Hospital, 223 N Van Dien Avenue

    Ridgewood, New Jersey, 07450, United States

  • West Virginia University Cancer Institute, 1 Medical Center Drive

    Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.