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Experimental cell therapy takes on lupus and muscle disease

NCT ID NCT07331272

Recruiting now Disease control Sponsor: Nanjing Legend Biotech Co. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing a new treatment called LUCAR-G79D for people with lupus or inflammatory myopathies that haven't responded to standard therapies. The treatment involves giving patients specially engineered immune cells to help control their disease. The study is small, with 38 adults, and focuses mainly on safety and finding the right dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LUCAR-G79D T cells (a type of immune cell therapy)
What this could lead to
If it works, this could point toward a new treatment option for people with hard-to-control lupus or inflammatory myopathies.
What could go wrong
This is a very early Phase 1 trial with only 38 people, so it may not work or could have serious side effects. The therapy also requires lifelong monitoring and may not lead to a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired idiopathic inflammatory myopathy myositis disease systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC INFLAMMATORY MYOPATHIES(IIM) SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Contacts and locations

Locations

  • Nanfang Hospital

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Affiliated Hospital of Xuzhou Medical University

    RECRUITING

    Xuzhou, Jiangsu, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The First Affiliated Hospital of Nanchang University

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Third The People's Hospital of Bengbu

    RECRUITING

    Bengbu, Anhui, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Xiangya Hospital of Central South University

    NOT_YET_RECRUITING

    Changsha, Hunan, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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