Experimental CAR T-Cell therapy targets two proteins to fight tough lymphoma
NCT ID NCT06295549
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested a new cell therapy called LUCAR-G39P in 11 patients with relapsed or refractory B-cell non-Hodgkin lymphoma. The therapy uses a patient's own immune cells, modified to attack two targets (CD19 and CD20) on cancer cells. The main goals were to check safety, side effects, and find the right dose. The study was terminated early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LUCAR-G39P cells (a type of CAR T-cell therapy that targets two proteins, CD19 and CD20, on cancer cells)
What this could lead to
If this therapy works, it could offer a new treatment option for patients with hard-to-treat B-cell lymphoma that has come back after other treatments.
What could go wrong
This is a very early phase 1 trial with only 11 patients, and it was terminated early. The therapy may cause serious side effects, and it is unknown if it will be effective or safe for broader use.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated Hospital of Nantong University
Nantong, Jiangsu, 226001, China
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Beijing Gobroad Hosptial
Beijing, 102206, China
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Department of Haematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital
Nanjin, Jiangsu, 210029, China