Hope for MSA: experimental drug aims to slow rare brain disease
NCT ID NCT05104476
First seen Oct 31, 2025 · Last updated May 12, 2026 · Updated 27 times
Summary
This study tests an experimental drug called Lu AF82422 in 64 people with multiple system atrophy (MSA), a rare and serious brain disease. The goal is to see if the drug can slow down the worsening of symptoms like movement problems and daily living difficulties. Participants receive either the drug or a placebo, and researchers measure changes using a standard rating scale over the treatment period.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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CenExel Rocky Mountain Clinical Research, LLC
Englewood, Colorado, 80113, United States
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Columbia University Medical Center - The Neurological Institute of New York
New York, New York, 10032, United States
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Endeavor Health - Glenbrook Hospital
Glenview, Illinois, 60026, United States
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Fujita Health University Hospital
Toyoake, Aichi-ken, 470-1192, Japan
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Gifu University Hospital
Gifu, Gifu, 501-1194, Japan
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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NYU Langone Health Medical Center
New York, New York, 10016, United States
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National Hospital Organization Sendai Nishitaga Hospital
Sendai, Miyagi, 982-8555, Japan
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Parkinson's Disease And Movement Disorder Center Of Boca Raton
Boca Raton, Florida, 33486, United States
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Penn State Milton S. Hershey Medical Center - Penn State Hershey Neuroscience Institute (PSHNI)
Hershey, Pennsylvania, 17033, United States
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Rush University Medical Center, Rush University Cancer Center
Chicago, Illinois, 60612, United States
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The Parkinsons and Movement Disorder Institute
Fountain Valley, California, 92708, United States
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University Nebraska Medical Center
Omaha, Nebraska, 68198-8440, United States
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University Of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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University of California - San Diego
La Jolla, California, 92037, United States
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University of California, San Francisco Neurosciences Clinical Research Unit
San Francisco, California, 94158, United States
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University of Florida Norman Fixel Institute for Neurological Diseases
Gainesville, Florida, 32608, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19107, United States
Conditions
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