New hope for never-smokers with advanced lung cancer: experimental drug combo enters phase 2 trial
NCT ID NCT05456256
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the experimental drug LP-300 to standard chemotherapy can help people who have never smoked and have advanced lung cancer that has returned after targeted therapy. About 90 participants will receive either the drug combo or chemo alone. The goal is to see if the combination slows cancer growth and extends life.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cancer and Blood Specialists Clinic
SUSPENDEDLos Alamitos, California, 90720, United States
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Chi Mei Medical Center
RECRUITINGTainan, Taiwan
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Fox Chase Cancer Center
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Hokkaido Cancer Center
ACTIVE_NOT_RECRUITINGSapporo, Hokkaido, Japan
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Inova Fairfax Hospital
RECRUITINGFairfax, Virginia, 22031, United States
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Kanagawa Cancer Center Hospital
ACTIVE_NOT_RECRUITINGYokohama, Kanagawa, Japan
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Los Angeles Cancer Network
RECRUITINGFountain Valley, California, 92708, United States
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National Cancer Center Hospital
ACTIVE_NOT_RECRUITINGChuo-ku, Tokyo, Japan
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National Cheng Kung University Hospital
RECRUITINGTainan, Taiwan
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National Taiwan University Hospital Hsin-Chu Branch
RECRUITINGHsinchu, Taiwan
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Okayama University Hospital
ACTIVE_NOT_RECRUITINGOkayama, Okayama-ken, Japan
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Precision NextGen Oncology and Research Center
RECRUITINGBeverly Hills, California, 90212, United States
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Taipei Veterans General Hospital
RECRUITINGTaipei, Taiwan
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Tohoku University Hospital
ACTIVE_NOT_RECRUITINGSendai, Miyagi, Japan
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TriService General Hospital-Neihu Main Facility
RECRUITINGTaipei, Taiwan
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75235, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can an oral chemo pill boost immunotherapy's power against lung cancer?
- Can an immunotherapy cocktail shrink inoperable lung tumors?
- Electric current test may forecast lung surgery complications
- Immunotherapy boosts radiation against early lung cancer
- Lab-Grown lung tumors could reveal why some drugs work and others fail