New hope for CLL patients: experimental drug LOXO-305 faces off against standard care
NCT ID NCT04666038
First seen May 04, 2026 · Last updated May 13, 2026 · Updated 2 times
Summary
This study compares a new oral drug, LOXO-305, to two standard treatment combinations (idelalisib plus rituximab or bendamustine plus rituximab) in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already been treated with a BTK inhibitor. The main goal is to see if LOXO-305 can delay cancer progression better than the standard options. About 238 participants will be followed for up to four years or longer.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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A.O.U. Citta' della Salute e della Scienza di Torino
Torino, 10126, Italy
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A.O.U. Policlinico G.Rodolico - S. Marco
Catania, 95123, Italy
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A.O.U. di Modena
Modena, 41124, Italy
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ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C
Milan, 20162, Italy
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ASST Spedali Civili - Università degli Studi
Brescia, 25123, Italy
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ASST-Monza -U.O Ematologia Adulti
Monza (MB) -Settore E, Piano 2, 20900, Italy
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AULSS8 Berica-Ospedale S.Bortolo
Vicenza, Veneto, 36100, Italy
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AZ Delta
Roeselare, West Flanders, 8800, Belgium
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AZ St-Elisabeth
Herentals, 2200, Belgium
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Aberdeen Royal Infirmary
Aberdeen, Aberdeen City, AB25 2ZN, United Kingdom
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Academician I.P. Pavlov First St-Petersburg State Medical University
Saint Petersburg, 197022, Russia
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Affiliated Tumor Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830002, China
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Aichi Cancer Center Hospital
Nagoya, Aichi-ken, 464-8681, Japan
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Ankara University Medicine Hospital
Mamak, Ankara, Turkey (Türkiye)
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Arizona Oncology Associates, P.C. - HOPE
Tucson, Arizona, 85711, United States
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Arnett Cancer Center
Lafayette, Indiana, 47904, United States
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Ascension St. John Hospital
Grosse Pointe Woods, Michigan, 48236, United States
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Az. Osp. "Card G Panico"
Tricase, 4 - 73039, Italy
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Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
Alessandria, 15100, Italy
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Azienda Ospedaliera Pugliese Ciaccio
Catanzaro, 88100, Italy
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Azienda Ospedaliera Santa Maria Terni
Terni, 05100, Italy
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Azienda Ospedaliera Universitaria Careggi
Florence, 50134, Italy
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Azienda Ospedaliero Universitaria Pisana
Pisa, PI, 56126, Italy
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Azienda Sanitaria Universitaria Giuliano Isontina
Trieste, 34125, Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, 24127, Italy
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Beaumont Hospital, Dublin
Dublin, DUBLIN 9, Ireland
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Beijing Hospital
Beijing, 100730, China
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Blood Institute of the Chinese Academy of Medical science
Tianjin, 300020, China
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Boca Raton Regional Hospital
Boca Raton, Florida, 33486, United States
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Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
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Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary"
Omsk, Omsk Oblast, 644013, Russia
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CHD Vendee
La Roche-sur-Yon, La Roche Sur Yon, 85000, France
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CHR Verviers-Onco
Verviers, Liege, 4800, Belgium
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CHRU De Tours
Tours, Tours Cedex 9, 37044, France
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CHRU de Brest - Hôpital Morvan
Brest, 29609, France
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CHU De Grenoble Hopital Albert Michallon
Grenoble, Cedex 09, 38043, France
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California Research Institute
Los Angeles, California, 90027, United States
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Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
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Cancer Care Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
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Cancer Center Office of Clinical Research
New Orleans, Louisiana, 70112, United States
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Cancer Specialists of North Florida -St Augustine
Jacksonville, Florida, 32256, United States
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Carmel Hospital
Haifa, Ḥeifā, 3436212, Israel
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Carolina Blood and Cancer Care Associates
Rock Hill, South Carolina, 29732, United States
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Castle Hill Hospital
Cottingham, East Yorkshire, HU16 5JQ, United Kingdom
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Centre Hospitalier Lyon Sud
Pierre-Bénite, Cedex, 69495, France
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Centre Hospitalier de la Côte Basque
Bayonne, 64109, France
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Centre Hospitalier du Mans
Le Mans, 72000, France
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Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
Rouen, Seine-Maritime, 76038, France
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Centrum Onkologii Ziemi Lubelskiej
Lublin, Lublin Voivodeship, 20-081, Poland
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Ch Perpignan
Perpignan, 66046, France
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Chang Gung Memorial Hospital - Linkou
Taoyuan, (r.o.c.), Taiwan, 33342, Taiwan
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Charité Campus Virchow-Klinikum
Berlin, 12203, Germany
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China Medical University Hospital
Taichung, Taichung, 40447, Taiwan
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Chu Nimes/Institut De Cancerologie Du Gard
Nîmes, Nimes, 30900, France
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Clinica di Ematologia IOSI, Ospedale Bellinzona e Valli, Ente Ospedaliero Cantonale
Bellinzona, Svizzera, 6500, Switzerland
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Clinical Research Alliance, Inc.
Westbury, New York, 11590, United States
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Clinique Saint Pierre Ottignies
Ottignies, 1340, Belgium
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Community Health Network
Indianapolis, Indiana, 46250, United States
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Complejo Hospitalario Universitario de Santiago de Compostel
Santiago de Compostela, La Coruna, 15706, Spain
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
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Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
Budapest, 1097, Hungary
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Derriford Hospital
Plymouth, Devon, PL6 8DH, United Kingdom
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Division of Hematology, Dept. of Internal Medicine, University Hospital Centre Zagreb
Zagreb, Croatia
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Dokuz Eylul University Faculty of Medicine
Izmir, 35330, Turkey (Türkiye)
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Ege University Medical Faculty
Izmir, 35100, Turkey (Türkiye)
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Erciyes University Faculty of Medicine
Kayseri, Melikgazi, 38039, Turkey (Türkiye)
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Fakultni nemocnice Brno
Brno, 62500, Czechia
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Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
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Federal State Budgetary Institution "Russian Scientific and Research Institute of Hematology and Transfusiology of Federal Medico-Biological Agency
Saint Petersburg, 191024, Russia
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, 00168, Italy
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Fudan University Shanghai Cancer Center
Shanghai, 200032, China
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Gachon University Gil Hospital
Namdong-gu, Incheon-gwangyeoksi [Incheon], 21565, South Korea
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Gansu Province Cancer Hospital
Lanzhou, Gansu, 730050, China
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Gazi University Faculty of Medicine
Ankara, Yenimahalle, 06560, Turkey (Türkiye)
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GenesisCare Cambridge
Newmarket, CB8 7XN, United Kingdom
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Gleneagles Medical Centre
Singapore, Central Singapore, 258499, Singapore
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Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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Groupe Jolimont
Haine-Saint-Paul, 7100, Belgium
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Hainan Province People's Hospital
Haikou, Hainan, 570100, China
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Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
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Hokkaido University Hospital
Sapporo, Hokkaido, 060-8648, Japan
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Hopital Saint Vincent De Paul
Lille, 59020, France
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Hospital AVICENNE
Bobigny, Cedex, 93 009, France
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Duran I Reynals
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, Planta Baja, 28007, Spain
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Hospital General de Albacete
Albacete, 02006, Spain
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Hospital San Pedro de Alcántara
Cáceres, 10003, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Infanta Leonor-INTERNAL MED
Madrid, 28031, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Marques De Valdecilla
Santander, 39008, Spain
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Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
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Hospital Universitario Ramon y Cajal
Madrid, Madrid, Comunidad de, 28034, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hospital Universitario de Alava
Vitoria-Gasteiz, 01005, Spain
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Hospital Universitario de Toledo
Toledo, Castille-La Mancha, 45004, Spain
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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IRCCS Ospedale Policlinico San Martino
Genova, 16132, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Illinois Cancer Specialists-Niles
Niles, Illinois, 60714, United States
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Ingham Institute of Medical Research
Liverpool, New South Wales, NSW2170, Australia
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Inje Univ Busan Paik Hospital
Busan, 47392, South Korea
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Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, 33076, France
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Instytut Hematologii i Transfuzjologii
Warsaw, 02-776, Poland
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Irccs Crob
Rionero in Vulture, Potenza, 85028, Italy
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Irccs Istituto Tumori Giovanni Paolo Ii
Viale Orazio Flacco, Bari, 70124, Italy
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Istanbul University Istanbul Medicine Faculty
Faith, Istanbul, Turkey (Türkiye)
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Istituto di Ematologia-C.R.E.O. (Centro di Ricerche Emato-Oncologich)
Perugia, 06132, Italy
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JCHO Kyushu Hospital
Fukoka-ken, 806 8501, Japan
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Japanese Foundation for Cancer Research
Koto, Tokyo, 135-8550, Japan
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Kindai University Hospital
Osaka Sayama-shi, Osaka, 589 8511, Japan
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Kobe City Medical Center General Hospital
Kobe, Hyōgo, 650-0047, Japan
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Kochi Medical School Hospital
Nankoku, Kochi, 783-8505, Japan
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Laniado Medical Center
Netanya, 4244916, Israel
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Lübecker Onkologische Schwerpunktpraxis
Lübeck, Schleswig-Holstein, 23562, Germany
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Mater Misericordiae Hospital
Dublin, Ireland
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Medical Oncology Hematology Consultants, PA
Newark, Delaware, 19713, United States
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Medizinische Universität Wien
Vienna, 1090, Austria
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Memorial Sloan Kettering Cancer Center
New York, New York, 10021, United States
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Mercy Health-Paducah Medical Oncology and Hematology
Paducah, Kentucky, 42003, United States
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Milton Keynes University Hospital
Milton Keynes, MK6 5LD, United Kingdom
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Minnesota Oncology/Hematology PA
Saint Paul, Minnesota, 55102, United States
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Mitchell Cancer Institute -University of South Alabama
Mobile, Alabama, 36604, United States
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München Klinik Schwabing
Koelner Platz 1, München, 80804, Germany
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NHO Sendai Medical Center
Sendai, Miyagi, 983-8520, Japan
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NTT Medical Center Tokyo
Shinagawa-Ku, Tokyo, 141-8625, Japan
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Nagoya City University Hospital
Nagoya, Aichi-ken, 467-8602, Japan
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Nagoya Medical Center
Nagoya, Aichi-ken, 460-0001, Japan
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Warsaw, 02-781, Poland
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Nebraska Hematology-Oncology
Lincoln, Nebraska, 68506, United States
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New Jersey Center for Cancer Research
Brick, New Jersey, 08724, United States
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Norfolk and Norwich Hospital
Norwich, Norfolk, NR4 7UY, United Kingdom
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Northwest Medical Specialties, PLLC
Tacoma, Washington, 98405, United States
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Norton Cancer Institute
Louisville, Kentucky, 40207, United States
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Oddzial Hematologiczny, Specjalistyczny Szpital im. dra Sokołowskiego w Wałbrzychu
Wałbrzych, 58-309, Poland
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Ogaki Municipal Hospital
Ogaki-shi, Gifu, 503-8502, Japan
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Okayama University Hospital
Okayama, 700-8558, Japan
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Oncology Dispensary #2 of Krasnodar Region
Sochi, 354057, Russia
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Oncology Hematology Care Inc
Cincinnati, Ohio, 45236, United States
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Oncology and Hematology Associates of Southwest Virginia Inc
Roanoke, Virginia, 24014, United States
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Oncology-Hematology Associates of West Broward
Tamarac, Florida, 33321, United States
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Orange Coast Memorial Medical Center
Fountain Valley, California, 92708, United States
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Ordensklinikum Linz GmbH Elisabethinen
Linz, Upper Austria, 4020, Austria
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Osaka University Hospital
Osaka, 565-0871, Japan
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Ospedale Papardo
Messina, 98158, Italy
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Ospedale Policlinico Giambattista Rossi, Borgo Roma
Verona, 37134, Italy
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Ospedale Santa Maria delle Croci
Ravenna, 48020, Italy
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Palo Verde Hematology Oncology
Glendale, Arizona, 85304, United States
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
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Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
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Pole Regionalde Cancérologie(CHU de Poitiers)
Politiers, Politiers, 86021, France
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Pratia MCM Krakow
Krakow, 30-510, Poland
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Pratia Onkologia Katowice
Katowice, 40519, Poland
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Princess Margaret Hospital (Ontario)
Toronto, Ontario, M5G 1Z5, Canada
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Pusan National University Hospital
Busan, Pusan-Kwangyǒkshi, 49241, South Korea
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Queen Elizabeth II Health Sciences Center
Halifax, Nova Scotia, B3H 1V7, Canada
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Rabin Medical Center
Petah Tikva, Central District, Israel
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Rocky Mountain Cancer Center
Aurora, Colorado, 80012, United States
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Royal Marsden Hospital
Sutton, Surrey, SM2 5PT, United Kingdom
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Royal Perth Hospital
Perth, Western Australia, 6000, Australia
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106, United States
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Saitama Medical Center
Kawagoe, Saitama, 350-8550, Japan
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Seoul National University Hospital
Seoul, Seoul, Korea, 03080, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
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Shanghai Jiaotong University School of Medicine Ruijin Hospital
Shanghai, 200025, China
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Singleton Hospital
Swansea, SA2 8QA, United Kingdom
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Soroka Medical Center
Beersheba, 8457108, Israel
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Southern Cancer Center, P.C.
Daphne, Alabama, 36526, United States
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Southern Medical University Nanfang Hospital
Guangzhou, Guangdong, 510515, China
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Southlake Regional Health Centre
Newmarket, Ontario, L3Y 2P9, Canada
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St James's Hosptial
Dublin, D08 NHY1, Ireland
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St James's University Hospital
Leeds, LS9 7TF, United Kingdom
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St Johns Hospital at Howden
Livingston, West Lothian, EH54 6PP, United Kingdom
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St Vincent's Hospital
Darlinghurst, New South Wales, 2010, Australia
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St. Vincent Frontier Cancer Center
Billings, Montana, 59102, United States
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Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, 510000, China
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SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz
Nyíregyháza, 4400, Hungary
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Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im.ks.B.Markiewicza
Brzozów, 36-200, Poland
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Szpital Uniwersytecki nr 2 im. dr Jana Biziela w BydgoszczyKlinika Hematologii
Bydgoszcz, 85-168, Poland
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Szpitale Pomorskie Sp. z o. o.
Gdynia, Pomeranian Voivodeship, 81-519, Poland
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Taipei Veterans General Hospital
Taipei, 112201, Taiwan
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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Texas Oncology - Amarillo
Amarillo, Texas, 79106, United States
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Texas Oncology - Dallas Presbyterian Hospital
Dallas, Texas, 75231, United States
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Texas Oncology - McAllen
McAllen, Texas, 78503, United States
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Texas Oncology - Medical City Dallas
Dallas, Texas, 75230, United States
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Texas Oncology - San Antonio Medical Center
San Antonio, Texas, 78240, United States
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Texas Oncology Cancer Center
Austin, Texas, 78705, United States
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Texas Oncology Fort Worth
Fort Worth, Texas, 76104, United States
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The Affiliated Hospital of Xuzhou Medical College
Xuzhou, Jiangsu, 221006, China
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The Catholic University of Korea-Seoul St. Mary's Hospital
Seocho-Gu, Seoul, 06591, South Korea
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The Center for Cancer and Blood Disorders
Fort Worth, Texas, 76104, United States
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The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
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The Royal Cornwall Hospital
Truro, Cornwall, TR1 3LJ, United Kingdom
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The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
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The St. George Hospital
Kogarah, New South Wales, 2217, Australia
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, Tianjin Municipality, China
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Tohoku University Hospital
Sendai, Miyagi, 980-8574, Japan
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Tokai University Hospital- Isehara Campus
Isehara, Kanagawa, 259-1143, Japan
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Tri-Service General Hospital
Taipei City, Taipei, 114, Taiwan
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Uniklinik Köln
Kerpener, Köln, 50937, Germany
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Uniklinikum Salzburg
Salzburg, Osterreich, 5020, Austria
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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University College London Hospitals
London, Greater London, WC1E 6HX, United Kingdom
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University Hospital Split
Split, 21000, Croatia
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University of Kentucky Markey Cancer Center
Lexington, Kentucky, 40563, United States
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University of Pecs 1st. Internalmedicin Clinic Dept
Pécs, 7624, Hungary
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University of Rochester
Rochester, New York, 14642, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53705, United States
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Universitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitätsklinikum Schleswig-Holstein
Kiel, Schleswig-Holstein, 24105, Germany
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Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, 89081, Germany
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Universitätsmedizin Mainz III. Medizinische Klinik und Poliklinik
Langenbeckstraße 1, Mainz, D- 55131, Germany
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Uniwersytecki Szpital Kliniczny Klinika
Wroclaw, 50-367, Poland
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Uniwersyteckie Centrum Kliniczne
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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VITAZ
Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium
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Virginia Cancer Specialists, PC
Gainesville, Virginia, 20155, United States
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Vseobecna fakultni nemocnice v Praze
Prague, 12808, Czechia
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WellStar Health System
Marietta, Georgia, 30060, United States
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Western General Hospital
Edinburgh, Scotland, EH4 2XU, United Kingdom
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Westmead Hospital
Wentworthville, New South Wales, 2145, Australia
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Willamette Valley Cancer Institute and Research Center
Eugene, Oregon, 97401, United States
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Wojewodzki Szpital Specjalistyczny
Iwaszkiewicza 5, Legnica, 59-220, Poland
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Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii
Lodz, 93510, Poland
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Xuanwu Hospital Capital Medical University
Xicheng District, Beijing Municipality, 100053, China
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China
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Zhejiang Provincial Taizhou Hospital
Linhai, Zhejiang, 317000, China
Conditions
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