New pill shows promise for Hard-to-Treat blood cancers
NCT ID NCT03740529
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 24 times
Summary
This study tested an oral drug called LOXO-305 (pirtobrutinib) in 803 people with chronic lymphocytic leukemia, small lymphocytic lymphoma, or other non-Hodgkin lymphomas whose cancer had stopped responding to or could not tolerate standard treatments. The goal was to find the best dose, check safety, and see if the drug could shrink tumors. Participants took the drug by mouth, and some also received it with other medications. The study aimed to control the disease rather than cure it.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
Nantes, 44093, France
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Churchill Hospital
Oxford, OX3 7LJ, United Kingdom
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Derriford Hospital
Plymouth, Pl6 8DH, United Kingdom
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Durham VA Medical Center
Durham, North Carolina, 27705, United States
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Emory Clinic
Atlanta, Georgia, 30322, United States
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Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
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Florida Cancer Specialists
Sarasota, Florida, 34232, United States
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Florida Cancer Specialists ORLANDO/DDU
Lake Mary, Florida, 32746, United States
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Hokkaido University Hospital
Sapporo, Hokkaido, 060-8648, Japan
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IRCCS - AOU di Bologna
Bologna, 40138, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Instytut Hermatologii I Transfuzjologii
Warsaw, Poland
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Karolinska Institutet
Solna, AB, 171 65, Sweden
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Kindai University Hospital
Osakasayama-Shi, 589-8511, Japan
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Kochi Medical School Hospital
Nankoku, Kochi, 783-8505, Japan
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Kyoto Furitsu Medical University Hospital
Kyoto, 602-8566, Japan
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Linear Clinical Research
Nedlands, Western Australia, 6009, Australia
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Mary Crowley Cancer Research Center
Dallas, Texas, 75230, United States
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Mayo Clinic
Rochester, Minnesota, 55905-0002, United States
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Mayo Clinic of Scottsdale
Scottsdale, Arizona, 85259, United States
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Mayo Clinic-Jacksonville
Jacksonville, Florida, 32224, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Nagoya Medical Center
Nagoya, Aichi-ken, 460-0001, Japan
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National Cancer Center Hospital
Chuo Ku, Tokyo, 104-0045, Japan
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National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
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Northwell Health
New Hyde Park, New York, 11042, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Hospital
Columbus, Ohio, 43210, United States
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Okayama University Hospital
Okayama, 700-8558, Japan
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Ospedale Regionale Bellinzona e Valli
Bellinzona, Canton Ticino, 6500, Switzerland
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Pratia MCM Krakow
Krakow, 30-510, Poland
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Samsung Medical Center
Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
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Sarah Cannon Research Institute SCRI
Nashville, Tennessee, 37203, United States
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Scripps Coastal Medical Center
San Diego, California, 92103, United States
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Seattle Cancer Care Alliance
Seattle, Washington, 98195, United States
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Seoul National University Hospital
Seoul, 03080, South Korea
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Smilow Cancer Hospital at Yale-New Haven
New Haven, Connecticut, 06510, United States
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St James's University Hospital
Leeds, LS9 7TF, United Kingdom
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Swedish Medical Center
Seattle, Washington, 98104, United States
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Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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Tohoku University Hospital
Sendai, Miyagi, 980-8574, Japan
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Tokai University Hospital- Isehara Campus
Isehara, Kanagawa, 259-1193, Japan
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University of California San Francisco, Medical Center at Paranassus
San Francisco, California, 94117, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68105, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Pennsylvania Hospital
Philadelphia, Pennsylvania, 19104, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Utah Cancer Specialists
Salt Lake City, Utah, 84106, United States
Conditions
Explore the condition pages connected to this study.