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Could a 20% lower anesthetic dose make C-Sections safer?

NCT ID NCT07140640

Disease control Sponsor: Aswan University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial investigates whether reducing the dose of a spinal anesthetic (bupivacaine) by 20% can lower the risk of a high spinal block—a complication where anesthesia rises too high in the body, causing breathing or blood pressure problems—during cesarean delivery. Pregnant women aged 18-45 scheduled for a C-section will be randomly assigned to receive either the standard dose or a reduced dose. The study aims to see if the lower dose reduces this risk while still providing effective pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyperbaric bupivacaine (spinal anesthetic) at a 20% reduced dose
What this could lead to
If successful, this could establish a safer standard dose for spinal anesthesia in cesarean sections, reducing dangerous complications.
What could go wrong
The trial is early and may not show a significant benefit; lower doses might also risk inadequate anesthesia, requiring additional interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 666 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Pregnant women aged 18-45 years. * ASA physical status II-III. Exclusion Criteria: * • Twin pregnancies. * Contraindications to spinal anesthesia (e.g., coagulopathy, infection). * Patients with incomplete preoperative data for risk stratification.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section complications

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Aswan university

    RECRUITING

    Aswān, Aswan Governorate, 000, Egypt

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